Phosphatase and tensin homolog (Q416356)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60484

Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60484

Tensin phosphatase, C2 domain, protein family

1 reference

Tensin-type phosphatase domain, protein family

1 reference

Dual specificity phosphatase

1 reference

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

Protein-tyrosine phosphatase, active site, protein family

1 reference

phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

phosphatidylinositol-3-phosphatase activity

1 reference

8 April 2019

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

protein serine/threonine phosphatase activity

1 reference

8 April 2019

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

protein tyrosine phosphatase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

8 April 2019

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

protein tyrosine/serine/threonine phosphatase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

enzyme binding

1 reference

8 April 2019

Critical role for Daxx in regulating Mdm2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

platelet-derived growth factor receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

protein binding

19 references

8 April 2019

Rak functions as a tumor suppressor by regulating PTEN protein stability and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Rak functions as a tumor suppressor by regulating PTEN protein stability and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

PTEN inhibits BMI1 function independently of its phosphatase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

protein kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

anaphase-promoting complex binding

3 references

1 reference

8 April 2019

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

identical protein binding

1 reference

8 April 2019

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

lipid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

ubiquitin-specific protease binding

1 reference

8 April 2019

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

ionotropic glutamate receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

protein tyrosine kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60484&geneProductId=UniProtKB:P60484

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60484&geneProductId=UniProtKB:P60484

1 January 2018

1 January 2018

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60484&geneProductId=UniProtKB:P60484

PDZ domain binding

Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cell component

cytoplasm

A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Subcellular localization of intracellular protein tyrosine phosphatases in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

mitochondrion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cytoplasmic side of plasma membrane

1 reference

8 April 2019

Subcellular localization of intracellular protein tyrosine phosphatases in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

5 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Ubiquitination regulates PTEN nuclear import and tumor suppression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cell projection

dendritic spine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

apical plasma membrane

1 reference

8 April 2019

NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

plasma membrane

1 reference

8 April 2019

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

PML body

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

cytosol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

biological process

response to zinc ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

positive regulation of TRAIL-activated apoptotic signaling pathway

1 reference

8 April 2019

miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

response to organic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of G1/S transition of mitotic cell cycle

1 reference

8 April 2019

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

regulation of B cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of epithelial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

long-term depression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cell population proliferation

1 reference

8 April 2019

PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

neuron projection development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cellular response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of cell population proliferation

MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

PTEN regulation by Akt-EGR1-ARF-PTEN axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

regulation of myeloid cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

male mating behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

positive regulation of apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

inositol phosphate metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

response to arsenic-containing substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

memory

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

regulation of cellular localization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cellular response to decreased oxygen levels

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

prostate gland growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

platelet-derived growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of protein phosphorylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

8 April 2019

PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

response to nutrient

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

protein dephosphorylation

A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

protein stabilization

1 reference

8 April 2019

Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

positive regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

response to glucose

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

nervous system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

adult behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

phosphatidylinositol dephosphorylation

A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

6 references

8 April 2019

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

positive regulation of ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

response to inorganic substance

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

canonical Wnt signaling pathway

1 reference

8 April 2019

Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

phosphatidylinositol biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

negative regulation of ribosome biogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

dephosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

regulation of axon regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

response to estradiol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

response to ATP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of phagocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

protein kinase B signaling

ISS

cardiac muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

lipid metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

human ageing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

regulation of cell cycle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

maternal behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of myelination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

regulation of synaptic transmission, GABAergic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

endothelial cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

long-term potentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

peptidyl-tyrosine dephosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of axon regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of cardiac muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

protein deubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

negative regulation of epithelial to mesenchymal transition

1 reference

8 April 2019

Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of keratinocyte migration

1 reference

8 April 2019

Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cellular response to electrical stimulus

1 reference

8 April 2019

Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of wound healing, spreading of epidermal cells

1 reference

8 April 2019

Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of phosphatidylinositol 3-kinase signaling

Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

positive regulation of gene expression

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

positive regulation of cardiac muscle cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

response to activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cellular response to insulin stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cellular response to leptin stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

positive regulation of neuron differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cellular response to ethanol

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of potassium ion transmembrane transporter activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cellular response to nerve growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

cellular response to insulin-like growth factor stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of signaling receptor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of protein kinase B signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

7 references

8 April 2019

8 April 2019

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

TGFβ-stimulated microRNA-21 utilizes PTEN to orchestrate AKT/mTORC1 signaling for mesangial cell hypertrophy and matrix expansion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

negative regulation of cell migration

3 references

8 April 2019

MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

8 April 2019

Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

regulation of protein stability

1 reference

8 April 2019

Phosphorylation of the PTEN tail regulates protein stability and function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of focal adhesion assembly

1 reference

8 April 2019

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

negative regulation of vascular associated smooth muscle cell proliferation

1 reference

8 April 2019

PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

transcription initiation from RNA polymerase II promoter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

1 reference

8 April 2019

negative regulation of cyclin-dependent protein serine/threonine kinase activity

1 reference

8 April 2019

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484

http://purl.uniprot.org/uniprot/P60484

exact match

1 reference

https://docs.openalex.org/download-snapshot/snapshot-data-format

Identifiers.org

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016