Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway (Q41197935)

28 September 2017

title

Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway (English)

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28 September 2017

R J Lefkowitz

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28 September 2017

B E Hawes

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28 September 2017

L M Luttrell

series ordinal

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28 September 2017

T van Biesen

series ordinal

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28 September 2017

language of work or name

English

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publication date

1 May 1996

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Journal of Biological Chemistry

28 September 2017

published in

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28 September 2017

volume

271

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28 September 2017

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28 September 2017

page(s)

12133-12136

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Signal transduction via the MAP kinases: proceed at your own RSK.

28 September 2017

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

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Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane

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Activation of the MAP kinase pathway by the protein kinase raf

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Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

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Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras

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Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

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G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.

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Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway

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G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

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Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes

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An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

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Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk

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1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

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Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes

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A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

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Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

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G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes

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On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: wortmannin-sensitive pathway to activate mitogen-activated protein kinase

21 January 2018

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Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1 reference

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

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11 October 2022

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Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells.

1 reference

11 October 2022

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G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor

1 reference

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Some unique characteristics of thylakoid unisite ATPase

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11 October 2022

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Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation

1 reference

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Identifiers

DOI

10.1074/JBC.271.21.12133

1 reference

28 September 2017

1 reference