Inhibition of VEGF receptors causes lung cell apoptosis and emphysema (Q40761379)

23 September 2017

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema (English)

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23 September 2017

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Y Kasahara

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23 September 2017

R M Tuder

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23 September 2017

L Taraseviciene-Stewart

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23 September 2017

T D Le Cras

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23 September 2017

S Abman

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23 September 2017

P K Hirth

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23 September 2017

J Waltenberger

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23 September 2017

N F Voelkel

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23 September 2017

language of work or name

English

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publication date

1 December 2000

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Journal of Clinical Investigation

23 September 2017

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23 September 2017

106

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23 September 2017

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23 September 2017

1311-1319

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Animal models for chronic obstructive pulmonary disease: age of klotho and marlboro mice

23 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Vascular endothelial growth factor (VEGF) and its receptors

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Presence of double-strand breaks with single-base 3' overhangs in cells undergoing apoptosis but not necrosis

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Measurement of pulmonary emphysema

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Chronic obstructive pulmonary disease: a definition and implications of structural determinants of airflow obstruction for epidemiology

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity

24 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

The bronchial arteries in pulmonary emphysema

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Regulation of vascular growth and regression by matrix metalloproteinases in the rat aorta model of angiogenesis.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Abnormal lung growth and the development of pulmonary hypertension in the Fawn-Hooded rat.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Trafficking of newly synthesized surfactant protein A in isolated rat alveolar type II cells

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Newer aspects of the pulmonary vasculature in chronic lung disease. A comparative study

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Studies in alpha 1-antitrypsin deficiency.

19 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=387249

Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats

19 August 2018

1 reference

12 December 2020

Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice

1 reference

12 December 2020

VEGF is required for growth and survival in neonatal mice

1 reference

12 December 2020

Induction of apoptotic cell death in vascular endothelial cells cultured in three-dimensional collagen lattice

1 reference

12 December 2020

Pulmonary emphysema with special reference to vascular changes

1 reference

12 December 2020

Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis

1 reference

12 December 2020

Inhibition of angiogenesis decreases alveolarization in the developing rat lung

1 reference

12 December 2020

Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema

1 reference

12 December 2020

Detection of antileukoprotease in connective tissue of the lung

1 reference

12 December 2020

Agarose infiltration improves morphology of cryostat sections of lung

1 reference

12 December 2020

Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. American Thoracic Society

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI10259

1 reference

23 September 2017

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23 September 2017

PubMed publication ID

11104784

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