Insulin receptor internalization: molecular mechanisms and physiopathological implications (Q40569575)

21 September 2017

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title

Insulin receptor internalization: molecular mechanisms and physiopathological implications (English)

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negative regulation of insulin receptor signaling pathway by insulin receptor internalization

21 September 2017

main subject

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Gene Ontology release 2020-05-02

J L Carpentier

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21 September 2017

publication date

1 September 1994

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21 September 2017

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21 September 2017

volume

37 Suppl 2

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21 September 2017

page(s)

S117-24

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Calcium ions are required for the intracellular routing of insulin and its receptor

21 September 2017

cites work

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12 December 2020

The NPEY Sequence Is Not Necessary for Endocytosis and Processing of Insulin-Receptor Complexes

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12 December 2020

Internalization and recycling of insulin receptors in hepatoma cells. Absence of regulation by receptor occupancy

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12 December 2020

Biochemical and morphological evidence that the insulin receptor is internalized with insulin in hepatocytes

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12 December 2020

Insulin-induced receptor loss in the cultured human lymphocyte: quantitative morphological perturbations in the cell and plasma membrane

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12 December 2020

Lilly Lecture: molecular mechanisms of insulin resistance. Lessons from patients with mutations in the insulin-receptor gene

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12 December 2020

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation

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12 December 2020

Recruitment of epidermal growth factor and transferrin receptors into coated pits in vitro: differing biochemical requirements

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12 December 2020

Internalized insulin receptors are recycled to the cell surface in rat hepatocytes

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12 December 2020

The cell biology of the insulin receptor

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12 December 2020

Intracellular Translocation of Iodine-125-Labeled Insulin: Direct Demonstration in Isolated Hepatocytes

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12 December 2020

Down-regulation and recycling of insulin receptors. Effect of monensin on IM-9 lymphocytes and U-937 monocyte-like cells

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12 December 2020

The essential tyrosine of the internalization signal in lysosomal acid phosphatase is part of a β turn

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12 December 2020

Insulin-induced internalization of the insulin receptor in the isolated rat adipose cell. Detection of the internalized 138-kilodalton receptor subunit using a photoaffinity 125I-insulin

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12 December 2020

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

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12 December 2020

Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells

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12 December 2020

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

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12 December 2020

Clathrin, adaptors, and sorting

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12 December 2020

In vitro binding of the asialoglycoprotein receptor to the beta adaptin of plasma membrane coated vesicles

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12 December 2020

Robert Feulgen Prize Lecture 1993. The journey of the insulin receptor into the cell: from cellular biology to pathophysiology

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12 December 2020

Internalization pathway of C3b receptors in human neutrophils and its transmodulation by chemoattractant receptors stimulation

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12 December 2020

Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation

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12 December 2020

Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region

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12 December 2020

Recycling receptors: The round-trip itinerary of migrant membrane proteins

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12 December 2020

Receptor-mediated endocytosis: concepts emerging from the LDL receptor system

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12 December 2020

Defective internalization of insulin and its receptor in cells expressing mutated insulin receptors lacking kinase activity

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12 December 2020

Diacylglycerol modulation of insulin receptor from cultured human mononuclear cells. Effects on binding and internalization

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12 December 2020

Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase

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12 December 2020

Receptor-mediated endocytosis of insulin: inhibition of [125I]iodoinsulin internalization in insulin resistant diabetic states of man.

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12 December 2020

Mutagenesis of lysine 460 in the human insulin receptor. Effects upon receptor recycling and cooperative interactions among binding sites

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12 December 2020

125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography

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12 December 2020

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

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12 December 2020

Endocytosis is Inhibited in Hepatocytes From Diabetic Rats

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12 December 2020

Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.

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12 December 2020

A domain of the insulin receptor required for endocytosis in rat fibroblasts

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12 December 2020

Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

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12 December 2020

Co-localization of 125I-epidermal growth factor and ferritin-low density lipoprotein in coated pits: a quantitative electron microscopic study in normal and mutant human fibroblasts

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12 December 2020

The mechanism of receptor-mediated endocytosis: more questions than answers

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12 December 2020

The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV

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12 December 2020

Internalization of the human insulin receptor. The insulin-independent pathway

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12 December 2020

Banting lecture 1990. Beta-cells in type II diabetes mellitus

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12 December 2020

Annexin I is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor

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12 December 2020

Two steps of insulin receptor internalization depend on different domains of the beta-subunit

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12 December 2020

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor

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12 December 2020

Role of intracellular calcium and protein kinase C in the endocytosis of transferrin and insulin by HL60 cells

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12 December 2020

The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation

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12 December 2020

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12 December 2020

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects

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12 December 2020

Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro-Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis

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12 December 2020

Clathrin-coated pit-mediated receptor internalization. Role of internalization signals and receptor mobility

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12 December 2020

Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes

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12 December 2020

Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity

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12 December 2020

Membrane traffic in endocytosis: insights from cell-free assays

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12 December 2020

Intracellular pathway followed by the insulin receptor covalently coupled to 125I-photoreactive insulin during internalization and recycling

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12 December 2020

Banting lecture 1988. Role of insulin resistance in human disease

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12 December 2020

Evidence for insulin-induced internalization and degradation of insulin receptors in rat adipocytes

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12 December 2020

Receptor-mediated endocytosis of polypeptide hormones is a regulated process: inhibition of [125I]iodoinsulin internalization in hypoinsulinemic diabetes of rat and man

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12 December 2020

Characterization of the signal for rapid internalization of the bovine mannose 6-phosphate/insulin-like growth factor-II receptor

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12 December 2020

Tyrosine phosphorylation of the insulin receptor during insulin-stimulated internalization in rat hepatoma cells.

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12 December 2020

Rapid, reversible internalization of cell surface insulin receptors. Correlation with insulin-induced down-regulation

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12 December 2020

The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals

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12 December 2020

Identifiers

DOI

10.1007/BF00400835

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21 September 2017

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