NLR family pyrin domain containing 3 (Q4044963)

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mammalian protein found in Homo sapiens

NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
cryopyrin
cryopyrin, NACHT, LRR and PYD domains - containing protein 3
NACHT, LRR and PYD containing protein 3
CLR1.1
deafness, autosomal dominant 34
PYRIN-containing APAF1-like protein 1
cold-induced autoinflammatory syndrome 1 protein
NACHT, LRR and PYD domains-containing protein 3
NLRP3
Angiotensin/vasopressin receptor AII/AVP-like
cold autoinflammatory syndrome 1 protein
caterpillar protein 1.1
NLR Family, Pyrin Domain-Containing 3 Protein

Language	Label	Description	Also known as
English	NLR family pyrin domain containing 3	mammalian protein found in Homo sapiens	NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 cryopyrin cryopyrin, NACHT, LRR and PYD domains - containing protein 3 NACHT, LRR and PYD containing protein 3 CLR1.1 deafness, autosomal dominant 34 PYRIN-containing APAF1-like protein 1 cold-induced autoinflammatory syndrome 1 protein NACHT, LRR and PYD domains-containing protein 3 NLRP3 Angiotensin/vasopressin receptor AII/AVP-like cold autoinflammatory syndrome 1 protein caterpillar protein 1.1 NLR Family, Pyrin Domain-Containing 3 Protein

Statements

1 reference

13 November 2019

UniProt protein ID

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96P20

Death-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96P20

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96P20

NACHT-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NACHT nucleoside triphosphatase family

1 reference

based on heuristic

inferred from protein domain or family

DAPIN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

protein binding

determination method or standard

14 references

8 April 2019

GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Novel role of PKR in inflammasome activation and HMGB1 release

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Novel role of PKR in inflammasome activation and HMGB1 release

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Evaluation of Nod-like receptor (NLR) effector domain interactions

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

peptidoglycan binding

determination method or standard

1 reference

8 April 2019

NLRs join TLRs as innate sensors of pathogens

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

determination method or standard

4 references

8 April 2019

NLRs join TLRs as innate sensors of pathogens

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

extracellular region

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

endoplasmic reticulum

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

inflammasome complex

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

determination method or standard

determination method or standard

1 reference

14 January 2019

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20

determination method or standard

Golgi apparatus

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

biological process

defense response

determination method or standard

1 reference

8 April 2019

NLRs join TLRs as innate sensors of pathogens

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

detection of biotic stimulus

determination method or standard

1 reference

8 April 2019

NLRs join TLRs as innate sensors of pathogens

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

NLRP3 inflammasome complex assembly

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20

determination method or standard

negative regulation of acute inflammatory response

determination method or standard

1 reference

8 April 2019

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

positive regulation of interleukin-5 production

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

interleukin-18 production

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

immune system process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20

determination method or standard

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

1 reference

27 March 2018

NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20

determination method or standard

positive regulation of interleukin-13 production

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

positive regulation of T-helper 17 cell differentiation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

defense response to virus

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

protein complex oligomerization

determination method or standard

1 reference

8 April 2019

NLRs join TLRs as innate sensors of pathogens

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

regulation of inflammatory response

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

interleukin-1 beta production

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

inflammatory response

determination method or standard

4 references

8 April 2019

A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

negative regulation of NF-kappaB transcription factor activity

determination method or standard

1 reference

8 April 2019

Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

negative regulation of inflammatory response

determination method or standard

3 references

8 April 2019

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Phenotype, genotype, and sustained response to anakinra in 22 patients with autoinflammatory disease associated with CIAS-1/NALP3 mutations

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Hearing improvement in a patient with variant Muckle-Wells syndrome in response to interleukin 1 receptor antagonism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

1 reference

10 September 2018

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

apoptotic process

determination method or standard

1 reference

8 April 2019

Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

innate immune response

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

protein deubiquitination

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

defense response to Gram-positive bacterium

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

positive regulation of NF-kappaB transcription factor activity

determination method or standard

cellular response to peptidoglycan

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

negative regulation of NIK/NF-kappaB signaling

determination method or standard

1 reference

27 March 2018

Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96P20&geneProductId=UniProtKB:Q96P20

determination method or standard

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method or standard

negative regulation of NIK/NF-kappaB signaling

determination method or standard

cellular response to lipopolysaccharide

determination method or standard

3 references

8 April 2019

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

8 April 2019

NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96P20

determination method or standard

Gene Atlas image

PBB GE NLRP3 216015 s at fs.png
732 × 530; 10 KB

0 references

Identifiers

MeSH descriptor ID

subject named as

NLR Family, Pyrin Domain-Containing 3 Protein

0 references

D12.644.360.539.250

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000294752

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000294752

ENSP00000337383

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000337383

ENSP00000355452

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355452

ENSP00000355453

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355453

ENSP00000375703

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000375703

ENSP00000375704

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000375704

ENSP00000493937

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493937

ENSP00000494332

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494332

ENSP00000493674

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493674

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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