The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. (Q39674326)

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8 December 2019

title

The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent (English)

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8 December 2019

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8 December 2019

Keith R Laderoute

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8 December 2019

Joy M Calaoagan

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8 December 2019

Cindy Gustafson-Brown

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8 December 2019

A Merrill Knapp

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8 December 2019

Guo-Chun Li

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8 December 2019

Holly L Mendonca

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8 December 2019

Heather E Ryan

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8 December 2019

Zhaohui Wang

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language of work or name

English

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publication date

1 April 2002

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Molecular and Cellular Biology

8 December 2019

published in

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8 December 2019

volume

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issue

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8 December 2019

page(s)

2515-2523

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Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines

8 December 2019

cites work

1 reference

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c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription.

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Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation

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HIF-1 and mechanisms of hypoxia sensing

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14 September 2017

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AP-1: one switch for many signals

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Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

14 September 2017

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Cre recombinase mediated alterations of the mouse genome using embryonic stem cells

14 September 2017

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Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells

14 September 2017

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Post-translational control of the MEF2A transcriptional regulatory protein

14 September 2017

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Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human

14 September 2017

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

14 September 2017

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Epidermal growth factor induction of the c-jun promoter by a Rac pathway

14 September 2017

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Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells

14 September 2017

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Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

14 September 2017

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AP-1 function and regulation

14 September 2017

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Jun: transcription factor and oncoprotein

14 September 2017

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A new group of conserved coactivators that increase the specificity of AP-1 transcription factors

14 September 2017

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Cellular transformation and malignancy induced by ras require c-jun

14 September 2017

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B-ATF: a novel human bZIP protein that associates with members of the AP-1 transcription factor family

14 September 2017

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Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia

14 September 2017

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Regulation of c-jun expression during hypoxic and low-glucose stress

14 September 2017

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

14 September 2017

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

14 September 2017

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Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell.

14 September 2017

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Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc

14 September 2017

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Induction of protooncogene c-jun by serum growth factors

14 September 2017

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The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

14 September 2017

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The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells

14 September 2017

1 reference

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The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

14 September 2017

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14 September 2017

12 December 2020

Glycogen synthase kinase-3: functions in oncogenesis and development

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Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts

14 September 2017

1 reference

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A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK.

14 September 2017

1 reference

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c-jun cooperates with SV40 T-antigen to sustain MMP-2 expression in immortalized cells

14 September 2017

1 reference

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Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth.

25 September 2017

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Hypoxia response element of the human vascular endothelial growth factor gene mediates transcriptional regulation by nitric oxide: control of hypoxia-inducible factor-1 activity by nitric oxide

25 September 2017

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Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes

25 September 2017

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Intramolecular signal transduction in c-Jun

25 September 2017

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Hypoxia-associated induction of early growth response-1 gene expression

25 September 2017

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Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation.

15 June 2018

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The JUN kinase/stress-activated protein kinase pathway is required for epidermal growth factor stimulation of growth of human A549 lung carcinoma cells.

15 June 2018

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Regulation and function of the JNK subgroup of MAP kinases

15 June 2018

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Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

15 June 2018

1 reference

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Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

15 June 2018

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Enhancement of transforming growth factor-alpha synthesis in multicellular tumour spheroids of A431 squamous carcinoma cells

15 June 2018

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Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

15 June 2018

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15 June 2018

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c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells

21 August 2018

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Suppression of tumor growth through disruption of hypoxia-inducible transcription

21 August 2018

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

21 August 2018

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Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function.

21 August 2018

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Transcriptional coactivators potentiating AP-1 function in bone

21 August 2018

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Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

21 August 2018

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Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes.

21 August 2018

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Hypoxia-induced elevation in interleukin-8 expression by human ovarian carcinoma cells

21 August 2018

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12 December 2020

Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway

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c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

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12 December 2020

Detection of hypoxia in human squamous cell carcinoma by EF5 binding

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12 December 2020

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

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12 December 2020

Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types

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Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene

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The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-kappa B

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12 December 2020

EPAS1 trans-activation during hypoxia requires p42/p44 MAPK

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12 December 2020

Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal

1 reference

12 December 2020

10.1128/MCB.22.8.2515-2523.2002

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11909946%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11909946%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

PubMed publication ID

11909946

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11909946%20AND%20SRC:MED&resulttype=core&format=json