Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53. (Q39457857)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11238892%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

title

Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53 (English)

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5 November 2019

V Rotter

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5 November 2019

A Seluanov

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5 November 2019

A Falcovitz

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5 November 2019

A Sigal

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I Zurer

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G Shohat

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N Goldfinger

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language of work or name

English

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publication date

1 March 2001

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Molecular and Cellular Biology

5 November 2019

published in

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volume

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issue

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5 November 2019

page(s)

1552-1564

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Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage

5 November 2019

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12 September 2017

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Evaluation of long-term daily administration of oral low-dose etoposide in elderly patients with relapsing or refractory non-Hodgkin's lymphoma

12 September 2017

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Immortalization of human mammary epithelial cells transfected with mutant p53 (273his).

12 September 2017

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Serum- and calcium-induced differentiation of human keratinocytes is inhibited by the E6 oncoprotein of human papillomavirus type 16.

12 September 2017

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Investigation of the role of G1/S cell cycle mediators in cellular senescence

12 September 2017

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Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

12 September 2017

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WAF1, a potential mediator of p53 tumor suppression

12 September 2017

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

12 September 2017

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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

12 September 2017

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Increased activity of p53 in senescing fibroblasts

12 September 2017

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Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

12 September 2017

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Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts

12 September 2017

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Telomeres shorten during ageing of human fibroblasts

12 September 2017

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

12 September 2017

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Suppression of human colorectal carcinoma cell growth by wild-type p53

12 September 2017

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Telomere loss: mitotic clock or genetic time bomb?

12 September 2017

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12 September 2017

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12 September 2017

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

12 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathway

14 September 2017

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Down-regulation of Ku autoantigen, DNA-dependent protein kinase, and poly(ADP-ribose) polymerase during cellular senescence

25 September 2017

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From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging

25 September 2017

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Replicative senescence: implications for in vivo aging and tumor suppression

25 September 2017

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Replicative senescence: an old lives' tale?

25 September 2017

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The induction of apoptosis in proliferating human fibroblasts by oxygen radicals is associated with a p53- and p21WAF1CIP1 induction

25 September 2017

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Mechanisms of cellular senescence

25 September 2017

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p53; from inductive signal to cellular effect

25 September 2017

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Increased p53 Protein Associated with Aging in Human Diploid Fibroblasts

25 September 2017

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Elevated levels of wild-type p53 induced by radiolabeling of cells leads to apoptosis or sustained growth arrest

25 September 2017

1 reference

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Cancer chemotherapy in the older patient: what the medical oncologist needs to know

25 September 2017

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The biology of aging: the current research agenda

15 June 2018

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The biology of replicative senescence

15 June 2018

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E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts

15 June 2018

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Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved

15 June 2018

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Immortalization of rat embryo fibroblasts by the cellular p53 oncogene.

15 June 2018

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15 June 2018

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Interdigital cell death can occur through a necrotic and caspase-independent pathway.

17 June 2018

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The role of p53 and cell death by apoptosis and necrosis in 4-hydroperoxycyclophosphamide-induced limb malformations.

21 August 2018

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Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

21 August 2018

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

21 August 2018

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Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

21 August 2018

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Renal tolerance of cisplatin in patients more than 80 years old

21 August 2018

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12 December 2020

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

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12 December 2020

In vivo ubiquitination and proteasome-mediated degradation of p53(1)

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12 December 2020

p53-dependent induction of apoptosis by proteasome inhibitors

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12 December 2020

Cisplatin-based combination chemotherapy for elderly patients with non-small-cell lung cancer

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12 December 2020

Cancer chemotherapy in the elderly

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12 December 2020

Recent developments in the pharmacology of anticancer drugs in the elderly

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12 December 2020

Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome

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12 December 2020

Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation

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12 December 2020

10.1128/MCB.21.5.1552-1564.2001

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11238892%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11238892%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

11238892

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11238892%20AND%20SRC:MED&resulttype=core&format=json