PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription (Q39446565)

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English	PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

12 September 2017

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription (English)

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

0 references

circadian rhythm

0 references

Clock Dmel_CG7391

1 reference

GOA release 2020-03-11

Timeless Dmel_CG3234

1 reference

GOA release 2020-03-11

Period Dmel_CG2647

1 reference

GOA release 2020-03-11

Cycle Dmel_CG8727

1 reference

GOA release 2020-03-11

author name string

C Lee

1

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Europe PubMed Central

PMC publication ID

12 September 2017

K Bae

2

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Europe PubMed Central

PMC publication ID

12 September 2017

I Edery

3

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Europe PubMed Central

PMC publication ID

12 September 2017

language of work or name

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publication date

1 August 1999

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Europe PubMed Central

PMC publication ID

12 September 2017

Molecular and Cellular Biology

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Europe PubMed Central

PMC publication ID

12 September 2017

19

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Europe PubMed Central

PMC publication ID

12 September 2017

8

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

5316-5325

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC84375/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Molecular bases for circadian clocks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84375

12 September 2017

Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84375

12 September 2017

Two alternatively spliced transcripts from the Drosophila period gene rescue rhythms having different molecular and behavioral characteristics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84375

12 September 2017

Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators

1 reference

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Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB

1 reference

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12 September 2017

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon

1 reference

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double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation

1 reference

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12 September 2017

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless

1 reference

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12 September 2017

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless

1 reference

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12 September 2017

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.

1 reference

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Role of the CLOCK protein in the mammalian circadian mechanism

1 reference

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Molecular and behavioral analysis of four period mutants in Drosophila melanogaster encompassing extreme short, novel long, and unorthodox arrhythmic types

1 reference

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The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors

1 reference

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12 September 2017

Differential effects of light and heat on the Drosophila circadian clock proteins PER and TIM.

1 reference

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Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies

1 reference

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Distinct domains of IkappaBalpha regulate c-Rel in the cytoplasm and in the nucleus.

1 reference

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Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling

1 reference

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12 September 2017

Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila

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The murine Sim-2 gene product inhibits transcription by active repression and functional interference

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A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster

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Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway

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Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor

1 reference

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The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

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A light-entrainment mechanism for the Drosophila circadian clock

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Temporal phosphorylation of the Drosophila period protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84375

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Block in nuclear localization of period protein by a second clock mutation, timeless

1 reference

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12 September 2017

Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless

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Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT)

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Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation

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Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless

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Protein-protein interaction via PAS domains: role of the PAS domain in positive and negative regulation of the bHLH/PAS dioxin receptor-Arnt transcription factor complex

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84375

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The aryl hydrocarbon receptor complex

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DNA Binding Specificities and Pairing Rules of the Ah Receptor, ARNT, and SIM Proteins

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Identification of functional domains of the aryl hydrocarbon receptor

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12 September 2017

Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=84375

12 September 2017

Positional Cloning and Sequence Analysis of the Drosophila Clock Gene, timeless

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Clock Mutants of Drosophila melanogaster

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Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in Drosophila melanogaster

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Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

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Circadian oscillations in period gene mRNA levels are transcriptionally regulated

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The PAS domain confers target gene specificity of DrosophilabHLH/PAS proteins

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14 September 2017

Molecular genetic analysis of circadian rhythms in vertebrates and invertebrates

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17 June 2018

A Drosophila circadian clock

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17 June 2018

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.

1 reference

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17 June 2018

Regulation of nuclear entry of the Drosophila clock proteins period and timeless.

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17 June 2018

Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light

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Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock

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A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene

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Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila.

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The 69 bp circadian regulatory sequence (CRS) mediates per-like developmental, spatial, and circadian expression and behavioral rescue in Drosophila.

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The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex.

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A clockwork explosion!

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Genetics of biological rhythms in drosophila.

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21 August 2018

Resetting the Drosophila clock by photic regulation of PER and a PER-TIM complex

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21 August 2018

PAS is a dimerization domain common to Drosophila period and several transcription factors.

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21 August 2018

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.

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21 August 2018

Alterations of per RNA in noncoding regions affect periodicity of circadian behavioral rhythms

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12 December 2020

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An ultrashort clock mutation at the period locus of Drosophila melanogaster that reveals some new features of the fly's circadian system

1 reference

https://pubmed.ncbi.nlm.nih.gov/10409723

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.19.8.5316

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 September 2017

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