Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta (Q38843924)

6 September 2017

title

Chloroquine inhibits the malignant phenotype of glioblastoma partially by suppressing TGF-beta (English)

1 reference

6 September 2017

0 references

1 reference

1 reference

David Fortin

1 reference

6 September 2017

Laurent-Olivier Roy

1 reference

6 September 2017

Marie-Belle Poirier

series ordinal

1 reference

6 September 2017

publication date

15 August 2015

1 reference

Investigational New Drugs

6 September 2017

published in

1 reference

6 September 2017

1 reference

6 September 2017

1 reference

6 September 2017

page(s)

1020-1031

1 reference

CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009.

6 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Chemoresistance of glioblastoma cancer stem cells--much more complex than expected

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Current clinical development of PI3K pathway inhibitors in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Retrospective study of carmustine or lomustine with bevacizumab in recurrent glioblastoma patients who have failed prior bevacizumab

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Institutional experience with chloroquine as an adjuvant to the therapy for glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Transforming growth factor-beta (TGF-beta)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Processing of transforming growth factor beta 1 precursor by human furin convertase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

RNA interference targeting transforming growth factor-beta enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Transforming growth factor-beta: vasculogenesis, angiogenesis, and vessel wall integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Glioma cell invasion: regulation of metalloproteinase activity by TGF-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Expression of TGF-beta isoforms, TGF-beta receptors, and SMAD molecules at different stages of human glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Transforming growth factor-beta and its implication in the malignancy of gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

The role of transforming growth factor beta in glioma progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Intracerebral and intrathecal infusion of the TGF-beta 2-specific antisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: toxicology and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Systemic inhibition of transforming growth factor-beta in glioma-bearing mice improves the therapeutic efficacy of glioma-associated antigen peptide vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Infiltration of glioma cells in brain parenchyma stimulated by radiation in the F98/Fischer rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Malignant gliomas in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Post-translational processing of the insulin-like growth factor-2 precursor. Analysis of O-glycosylation and endoproteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Precursor processing by kex2/furin proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

BCL-2-induced glioma cell invasiveness depends on furin-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Medical need, scientific opportunity and the drive for antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

In Vitro Chloroquine Resistance in Plasmodium falciparum Isolates from Tertiary Care Hospital

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Chloroquine or chloroquine-PI3K/Akt pathway inhibitor combinations strongly promote γ-irradiation-induced cell death in primary stem-like glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Immune defects observed in patients with primary malignant brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Disposition of chloroquine in man after single intravenous and oral doses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Pharmacokinetic interactions between primaquine and chloroquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Pharmacokinetic interaction of chloroquine and methylene blue combination against malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Improving the prediction of the brain disposition for orally administered drugs using BDDCS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10637-015-0275-X

Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas

21 January 2018

1 reference

12 December 2020

Mitosis-targeted anti-cancer therapies: where they stand.

1 reference

12 December 2020

Bevacizumab and glioblastoma: scientific review, newly reported updates, and ongoing controversies

1 reference

12 December 2020

Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class.

1 reference

12 December 2020

Chloroquine-induced autophagic vacuole accumulation and cell death in glioma cells is p53 independent

1 reference

12 December 2020

Regulation of lymphokine-activated killer activity and pore-forming protein gene expression in human peripheral blood CD8+ T lymphocytes. Inhibition by transforming growth factor-beta

1 reference

12 December 2020

Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia

1 reference

12 December 2020

Chloroquine and hydroxychloroquine for cancer therapy

1 reference

12 December 2020

10.1007/S10637-015-0275-X

Identifiers

DOI

1 reference

Dimensions Publication ID

6 September 2017

1006740601

0 references

1 reference