TIMPs: versatile extracellular regulators in cancer (Q38785433)

6 September 2017

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title

TIMPs: versatile extracellular regulators in cancer (English)

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6 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27932800%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27932800%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Virginie Defamie

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27932800%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Paul Waterhouse

series ordinal

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27932800%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

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publication date

9 December 2016

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6 September 2017

published in

Nature Reviews Cancer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27932800%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27932800%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27932800%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

38-53

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27932800%20AND%20SRC:MED&resulttype=core&format=json

Emerging roles of proteases in tumour suppression

7 June 2020

cites work

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Transcriptional regulation of two serum-induced RNAs in mouse fibroblasts: equivalence of one species to B2 repetitive elements

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Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells

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The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity

21 January 2018

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Tissue inhibitors of metalloproteinases

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Insights into MMP-TIMP interactions.

21 January 2018

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Constraining specificity in the N-domain of tissue inhibitor of metalloproteinases-1; gelatinase-selective inhibitors

21 January 2018

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Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease

21 January 2018

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Catalytic properties of ADAM12 and its domain deletion mutants

21 January 2018

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ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3

21 January 2018

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Threonine 98, the pivotal residue of tissue inhibitor of metalloproteinases (TIMP)-1 in metalloproteinase recognition

21 January 2018

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Mapping and characterization of the functional epitopes of tissue inhibitor of metalloproteinases (TIMP)-3 using TIMP-1 as the scaffold: a new frontier in TIMP engineering

21 January 2018

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Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme

21 January 2018

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Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.

21 January 2018

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Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP-3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRC.2016.115

Expression and epigenetic regulation of angiogenesis-related factors during dormancy and recurrent growth of ovarian carcinoma

21 January 2018

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Identification and characterization of human tissue inhibitor of metalloproteinase-3 and detection of three additional metalloproteinase inhibitor activities in extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Sulfated glycosaminoglycans control the extracellular trafficking and the activity of the metalloprotease inhibitor TIMP-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Glycosylation in cancer: mechanisms and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Overexpression and β-1,6-N-acetylglucosaminylation-initiated aberrant glycosylation of TIMP-1: a "double whammy" strategy in colon cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Extracellular regulation of metalloproteinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

The matrix corroded: podosomes and invadopodia in extracellular matrix degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinase 1 (TIMP-1) promotes plasmablastic differentiation of a Burkitt lymphoma cell line: implications in the pathogenesis of plasmacytic/plasmablastic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27(KIP1) protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/β-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinases-2 (TIMP-2) suppresses TKR-growth factor signaling independent of metalloproteinase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-2 disrupts FGF-2-induced downstream signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-1 as a tumor marker in breast cancer--an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Serum TIMP-1 predicts survival outcomes of invasive breast carcinoma patients: a meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Prognostic significance of tissue inhibitor of metalloproteinase-1 in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Low expression of tissue inhibitor of metalloproteinases-1 (TIMP-1) in glioblastoma predicts longer patient survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Serum TIMP-1 and response to the aromatase inhibitor letrozole versus tamoxifen in metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

HER2, TOP2A, and TIMP-1 and responsiveness to adjuvant anthracycline-containing chemotherapy in high-risk breast cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Urinary TIMP-1 and MMP-2 levels detect the presence of pancreatic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Serum biomarker panels for the detection of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitors of metalloproteinase expression in human breast cancer: TIMP-3 is associated with adjuvant endocrine therapy success.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Frequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Frequent methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene in pancreatic endocrine tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Loss of TIMP-3 promotes tumor invasion via elevated IL-6 production and predicts poor survival and relapse in HPV-infected non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Methylated TIMP-3 DNA in body fluids is an independent prognostic factor for gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Prognostic significance of TIMP3 hypermethylation in post-treatment salivary rinse from head and neck squamous cell carcinoma patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Epigenetic inactivation of the tissue inhibitor of metalloproteinase-2 (TIMP-2) gene in human prostate tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Expression of tissue inhibitor of metalloproteinases TIMP-2 in human colorectal cancer--a predictor of tumour stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinases-4. The road less traveled.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical course

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Long-term exposure to elevated levels of circulating TIMP-1 but not mammary TIMP-1 suppresses growth of mammary carcinomas in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-1 activated carcinoma-associated fibroblasts inhibit tumor apoptosis by activating SDF1/CXCR4 signaling in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-1 promotes accumulation of cancer associated fibroblasts and cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

A phenotype from tumor stroma based on the expression of metalloproteases and their inhibitors, associated with prognosis in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-1 via TWIST1 induces EMT phenotypes in human breast epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

MMP inhibitors augment fibroblast adhesion through stabilization of focal adhesion contacts and up-regulation of cadherin function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tensional homeostasis and the malignant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

LOXL2-mediated matrix remodeling in metastasis and mammary gland involution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Interactions between cancer stem cells and their niche govern metastatic colonization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Structural and functional uncoupling of the enzymatic and angiogenic inhibitory activities of tissue inhibitor of metalloproteinase-2 (TIMP-2): loop 6 is a novel angiogenesis inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Retroviral vector-producer cell-mediated in vivo gene transfer of TIMP-3 restricts angiogenesis and neuroblastoma growth in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Metalloproteinases and their natural inhibitors in inflammation and immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

CANCER. How neutrophils promote metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

On the dual roles and polarized phenotypes of neutrophils in tumor development and progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinase-3 regulates inflammation in human and mouse intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Stromal TIMP3 regulates liver lymphocyte populations and provides protection against Th1 T cell-driven autoimmune hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Timp3 deficient mice show resistance to developing breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Extracellular control of TGFbeta signalling in vascular development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Quantitative analysis of the secretome of TGF-beta signaling-deficient mammary fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TGF-β promotes heterogeneity and drug resistance in squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tumor cell-derived Timp-1 is necessary for maintaining metastasis-promoting Met-signaling via inhibition of Adam-10.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

ADAMs: key components in EGFR signalling and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

EGFR ligands and their signaling scissors, ADAMs, as new molecular targets for anticancer treatments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Targeting TACE-dependent EGFR ligand shedding in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Targeting the sheddase activity of ADAM17 by an anti-ADAM17 antibody D1(A12) inhibits head and neck squamous cell carcinoma cell proliferation and motility via blockage of bradykinin induced HERs transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

EGF receptor is required for KRAS-induced pancreatic tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Anti-microRNA-222 (anti-miR-222) and -181B suppress growth of tamoxifen-resistant xenografts in mouse by targeting TIMP3 protein and modulating mitogenic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Relationships between serum HER2 ECD, TIMP-1 and clinical outcomes in Taiwanese breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Targeting MET in cancer: rationale and progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinase-3 induces a Fas-associated death domain-dependent type II apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Accelerated apoptosis in the Timp-3-deficient mammary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

A four-marker signature of TNF-RII, TGF-α, TIMP-1 and CRP is prognostic of worse survival in high-risk surgically resected melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Matrix metalloproteinases play an active role in Wnt1-induced mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

The heparanase/syndecan-1 axis in cancer: mechanisms and therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Unraveling hidden regulatory sites in structurally homologous metalloproteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Systems-level analysis of proteolytic events in increased vascular permeability and complement activation in skin inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Monitoring matrix metalloproteinase activity at the epidermal-dermal interface by SILAC-iTRAQ-TAILS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Detection of matrix metalloproteinase active forms in complex proteomes: evaluation of affinity versus photoaffinity capture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Halogen bonding controls selectivity of FRET substrate probes for MMP-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Targeted proteomics by selected reaction monitoring mass spectrometry: applications to systems biology and biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Downregulation of miR-221/222 enhances sensitivity of breast cancer cells to tamoxifen through upregulation of TIMP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

MiR-221/222 promote human glioma cell invasion and angiogenesis by targeting TIMP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Oncogenic miR-20a and miR-106a enhance the invasiveness of human glioma stem cells by directly targeting TIMP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Upregulated miR-106a plays an oncogenic role in pancreatic cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Endometrial miR-181a and miR-98 expression is altered during transition from normal into cancerous state and target PGR, PGRMC1, CYP19A1, DDX3X, and TIMP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21-Mediated Matrix Metalloproteinase Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in vivo effects of MiR-21 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

CD23 Sheddase A disintegrin and metalloproteinase 10 (ADAM10) is also required for CD23 sorting into B cell-derived exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Abnormal TNF activity in Timp3 −/− mice leads to chronic hepatic inflammation and failure of liver regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinases 1 regulation of interleukin-10 in B-cell differentiation and lymphomagenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

The absence of immunoreactivity for tissue inhibitor of metalloproteinase-1 (TIMP-1), but not for TIMP-2, protein is associated with a favorable prognosis in aggressive breast carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Evaluation in pre-diagnosis samples discounts ICAM-1 and TIMP-1 as biomarkers for earlier diagnosis of pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Promoter methylation and expression of TIMP3 gene in gastric cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Promoter hypermethylation contributes to TIMP3 down-regulation in high stage endometrioid endometrial carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Immunoreactivity for TIMP-2 is associated with a favorable prognosis in endometrial carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

mRNA expression of matrix metalloproteases and their inhibitors differs in subtypes of renal cell carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Expression of matrix metalloproteinase-26 and tissue inhibitors of metalloproteinases TIMP-3 and -4 in benign endometrium and endometrial cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-3 deficiency in the host, but not in the tumor, enhances tumor growth and angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3-/- mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

AdTIMP-2 inhibits tumor growth, angiogenesis, and metastasis, and prolongs survival in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

ADAM10 and ADAM17 have opposite roles during sprouting angiogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits tumor growth and angiogenesis in the TIMP-1 transgenic mouse model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP3 controls cell fate to confer hepatocellular carcinoma resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Expression of insulin-like growth factor-II, matrix metalloproteinases, and their tissue inhibitors as predictive markers in the peripheral blood of HCC patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tissue inhibitor of metalloproteinases-3 induces apoptosis in melanoma cells by stabilization of death receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Tumour necrosis factor and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.115

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor

31 March 2020

1 reference

12 December 2020

Transgenic TIMP-1 inhibits simian virus 40 T antigen-induced hepatocarcinogenesis by impairment of hepatocellular proliferation and tumor angiogenesis

1 reference

12 December 2020

Hydroxamate-type matrix metalloproteinase inhibitor batimastat promotes liver metastasis.

1 reference

12 December 2020

Altered tumor growth and metastasis of a T-cell lymphoma in Timp-1 transgenic mice

1 reference

12 December 2020

High serum TIMP-1 is associated with adverse prognosis in endometrial carcinoma

1 reference

12 December 2020

Tissue inhibitor of metalloproteinase-1 protects human breast epithelial cells from extrinsic cell death: a potential oncogenic activity of tissue inhibitor of metalloproteinase-1

1 reference

12 December 2020

Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2).

1 reference

12 December 2020

Metalloproteinase inhibition and erythroid potentiation are independent activities of tissue inhibitor of metalloproteinases-1.

1 reference

12 December 2020

High levels of tissue inhibitor of metalloproteinase-2 (TIMP-2) expression are associated with poor outcome in invasive bladder cancer.

1 reference

12 December 2020

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues

1 reference

12 December 2020

Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact.

1 reference

12 December 2020

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice.

1 reference

12 December 2020