HIV-1 gag: an emerging target for antiretroviral therapy. (Q38366763)

PubMed publication ID

2 September 2017

1 reference

title

HIV-1 gag: an emerging target for antiretroviral therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6941199&resulttype=core&format=json

13 May 2020

main subject

anti-retroviral agent

0 references

publication date

1 January 2015

1 reference

PubMed publication ID

25731773

Current Topics in Microbiology and Immunology

2 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6941199&resulttype=core&format=json

13 May 2020

volume

389

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6941199&resulttype=core&format=json

13 May 2020

page(s)

171-201

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6941199&resulttype=core&format=json

The dimerization domain of the HIV-1 capsid protein binds a capsid protein-derived peptide: a biophysical characterization

13 May 2020

cites work

1 reference

12 December 2020

Rab11-FIP1C and Rab14 direct plasma membrane sorting and particle incorporation of the HIV-1 envelope glycoprotein complex

1 reference

12 December 2020

Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release

1 reference

12 December 2020

Spontaneous mutations in the human immunodeficiency virus type 1 gag gene that affect viral replication in the presence of cyclosporins

1 reference

12 December 2020

Novel inhibitor binding site discovery on HIV-1 capsid N-terminal domain by NMR and X-ray crystallography

1 reference

12 December 2020

Hexagonal assembly of a restricting TRIM5alpha protein

1 reference

12 December 2020

Rationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activity

1 reference

12 December 2020

Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAV

1 reference

12 December 2020

Retroviral integrase proteins and HIV-1 DNA integration

1 reference

12 December 2020

Identification of a small-molecule inhibitor of HIV-1 assembly that targets the phosphatidylinositol (4,5)-bisphosphate binding site of the HIV-1 matrix protein.

1 reference

12 December 2020

Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity

1 reference

12 December 2020

Structure of the amino-terminal core domain of the HIV-1 capsid protein

1 reference

12 December 2020

On the role of the SP1 domain in HIV-1 particle assembly: a molecular switch?

1 reference

12 December 2020

Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection

1 reference

12 December 2020

Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer

1 reference

12 December 2020

p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease

1 reference

12 December 2020

HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation

1 reference

12 December 2020

Role of matrix in an early postentry step in the human immunodeficiency virus type 1 life cycle

1 reference

12 December 2020

Specific incorporation of cyclophilin A into HIV-1 virions

1 reference

12 December 2020

Safety and pharmacokinetics of Bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers

1 reference

12 December 2020

Lentivirus Vpr and Vpx accessory proteins usurp the cullin4-DDB1 (DCAF1) E3 ubiquitin ligase

1 reference

12 December 2020

Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly.

1 reference

12 December 2020

Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

1 reference

12 December 2020

Phase I and II study of the safety, virologic effect, and pharmacokinetics/pharmacodynamics of single-dose 3-o-(3',3'-dimethylsuccinyl)betulinic acid (bevirimat) against human immunodeficiency virus infection

1 reference

12 December 2020

Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

1 reference

12 December 2020

The role of cellular factors in promoting HIV budding

1 reference

12 December 2020

HIV-1 accessory proteins--ensuring viral survival in a hostile environment

1 reference

12 December 2020

Dolutegravir: first global approval

1 reference

12 December 2020

Structure and assembly of immature HIV

1 reference

12 December 2020

Human immunodeficiency virus type 1 nucleocapsid inhibitors impede trans infection in cellular and explant models and protect nonhuman primates from infection

1 reference

12 December 2020

Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication

1 reference

12 December 2020

Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.

1 reference

12 December 2020

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein

1 reference

12 December 2020

HIV: cell binding and entry

1 reference

12 December 2020

HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat.

1 reference

12 December 2020

High prevalence of bevirimat resistance mutations in protease inhibitor-resistant HIV isolates

1 reference

12 December 2020

HIV Gag polyprotein: processing and early viral particle assembly

1 reference

12 December 2020

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication

1 reference

12 December 2020

Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat

1 reference

12 December 2020

Crystallographic and Functional Analysis of the ESCRT-I /HIV-1 Gag PTAP Interaction

1 reference

12 December 2020

Transcriptional and posttranscriptional regulation of HIV-1 gene expression

1 reference

12 December 2020

Reevaluation of the requirement for TIP47 in human immunodeficiency virus type 1 envelope glycoprotein incorporation

1 reference

12 December 2020

Flexible use of nuclear import pathways by HIV-1.

1 reference

12 December 2020

In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (Bevirimat).

1 reference

12 December 2020

1 reference

12 December 2020

Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription

1 reference

12 December 2020

Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein

1 reference

12 December 2020

Determinants of activity of the HIV-1 maturation inhibitor PA-457.

1 reference

12 December 2020

Identification of HIV-1 inhibitors targeting the nucleocapsid protein.

1 reference

12 December 2020

Nucleic acid chaperone activity of retroviral Gag proteins

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12 December 2020

HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.

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12 December 2020

Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving antiretroviral therapy

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12 December 2020

Molecular determinants that regulate plasma membrane association of HIV-1 Gag

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12 December 2020

Mechanisms for Env glycoprotein acquisition by retroviruses

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12 December 2020

A peptide inhibitor of HIV-1 assembly in vitro

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12 December 2020

Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds

1 reference

12 December 2020

Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding

1 reference

12 December 2020

Structural determinants and mechanism of HIV-1 genome packaging

1 reference

12 December 2020

Entropic switch regulates myristate exposure in the HIV-1 matrix protein

1 reference

12 December 2020

The long cytoplasmic tail of gp41 is required in a cell type-dependent manner for HIV-1 envelope glycoprotein incorporation into virions

1 reference

12 December 2020

Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body

1 reference

12 December 2020

Binding of human immunodeficiency virus type 1 Gag to membrane: role of the matrix amino terminus.

1 reference

12 December 2020

Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail

1 reference

12 December 2020

Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis

1 reference

12 December 2020

Regulation of human immunodeficiency virus type 1 Env-mediated membrane fusion by viral protease activity

1 reference

12 December 2020

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

1 reference

12 December 2020

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

1 reference

12 December 2020

HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore

1 reference

12 December 2020

Global rescue of defects in HIV-1 envelope glycoprotein incorporation: implications for matrix structure

1 reference

12 December 2020

Multiple-dose pharmacokinetics and safety of bevirimat, a novel inhibitor of HIV maturation, in healthy volunteers

1 reference

12 December 2020

TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core

1 reference

12 December 2020

Solution Structure of a Hydrocarbon Stapled Peptide Inhibitor in Complex with Monomeric C-terminal Domain of HIV-1 Capsid

1 reference

12 December 2020

High prevalence of natural polymorphisms in Gag (CA-SP1) associated with reduced response to Bevirimat, an HIV-1 maturation inhibitor

1 reference

12 December 2020

Identification of host proteins required for HIV infection through a functional genomic screen

1 reference

12 December 2020

The late domain of human immunodeficiency virus type 1 p6 promotes virus release in a cell type-dependent manner

1 reference

12 December 2020

Human immunodeficiency virus type 1 protease triggers a myristoyl switch that modulates membrane binding of Pr55(gag) and p17MA.

1 reference

12 December 2020

The maturation inhibitor bevirimat (PA-457) can be active in patients carrying HIV type-1 non-B subtypes and recombinants.

1 reference

12 December 2020

Discovery and structural characterization of a new inhibitor series of HIV-1 nucleocapsid function: NMR solution structure determination of a ternary complex involving a 2:1 inhibitor/NC stoichiometry

1 reference

12 December 2020

Restriction of retroviral infection of macrophages

1 reference

12 December 2020

Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.

1 reference

12 December 2020

The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase

1 reference

12 December 2020

Entry inhibitors and their use in the treatment of HIV-1 infection

1 reference

12 December 2020

Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions

1 reference

12 December 2020

Cyclosporin A Provides No Sustained Immunologic Benefit to Persons with Chronic HIV‐1 Infection Starting Suppressive Antiretroviral Therapy: Results of a Randomized, Controlled Trial of the AIDS Clinical Trials Group A5138

1 reference

12 December 2020

The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection

1 reference

12 December 2020

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

1 reference

12 December 2020

HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries?

1 reference

12 December 2020

Role of the SP2 domain and its proteolytic cleavage in HIV-1 structural maturation and infectivity

1 reference

12 December 2020

Structure of full-length HIV-1 CA: a model for the mature capsid lattice

1 reference

12 December 2020

Global trends in molecular epidemiology of HIV-1 during 2000-2007.

1 reference

12 December 2020

Impact of human immunodeficiency virus type 1 resistance to protease inhibitors on evolution of resistance to the maturation inhibitor bevirimat (PA-457)

1 reference

12 December 2020

HIV-1 reverse transcription

1 reference

12 December 2020

HIV-1 matrix organizes as a hexamer of trimers on membranes containing phosphatidylinositol-(4,5)-bisphosphate

1 reference

12 December 2020

Synthesis and biological evaluation of a new derivative of bevirimat that targets the Gag CA-SP1 cleavage site

1 reference

12 December 2020

The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles

1 reference

12 December 2020

Structural basis for viral late-domain binding to Alix

1 reference

12 December 2020

Context surrounding processing sites is crucial in determining cleavage rate of a subset of processing sites in HIV-1 Gag and Gag-Pro-Pol polyprotein precursors by viral protease

1 reference

12 December 2020

Recent progress in antiretrovirals--lessons from resistance

1 reference

12 December 2020

Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription

1 reference

12 December 2020

A strongly transdominant mutation in the human immunodeficiency virus type 1 gag gene defines an Achilles heel in the virus life cycle

1 reference

12 December 2020

Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA.

1 reference

12 December 2020

Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction

1 reference

12 December 2020

Origins of HIV and the AIDS pandemic

1 reference

12 December 2020

Crystal structure of SIV matrix antigen and implications for virus assembly

1 reference

12 December 2020

Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient gag membrane binding

1 reference

12 December 2020

Membrane fission reactions of the mammalian ESCRT pathway

1 reference

12 December 2020

Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane

1 reference

12 December 2020

HIV-1 evades innate immune recognition through specific cofactor recruitment

1 reference

12 December 2020

Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein

1 reference

12 December 2020

Susceptibility of human immunodeficiency virus type 1 to the maturation inhibitor bevirimat is modulated by baseline polymorphisms in Gag spacer peptide 1

1 reference

12 December 2020

Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein

1 reference

12 December 2020

Virion incorporation of envelope glycoproteins with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency virus type 1 matrix.

1 reference

12 December 2020

A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.

1 reference

12 December 2020

Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag

1 reference

12 December 2020

Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for the treatment of AIDS.

1 reference

12 December 2020

Structural and functional insights into the HIV-1 maturation inhibitor binding pocket

1 reference

12 December 2020

A call for randomized controlled trials of antiretroviral therapy for HIV-2 infection in West Africa

1 reference

12 December 2020

The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

1 reference

12 December 2020

HIV-1 gag proteins: diverse functions in the virus life cycle

1 reference

12 December 2020

Differential membrane binding of the human immunodeficiency virus type 1 matrix protein

1 reference

12 December 2020

HIV drug development: the next 25 years

1 reference

12 December 2020

Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants

1 reference

12 December 2020

HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice

1 reference

12 December 2020

Structure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopy

1 reference

12 December 2020

Role of the Gag matrix domain in targeting human immunodeficiency virus type 1 assembly

1 reference

12 December 2020

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm.

1 reference

12 December 2020

Projected life expectancy of people with HIV according to timing of diagnosis

1 reference

12 December 2020

MX2 is an interferon-induced inhibitor of HIV-1 infection

1 reference

12 December 2020

Antiviral inhibition of the HIV-1 capsid protein

1 reference

12 December 2020

Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes

1 reference

12 December 2020

A cell-penetrating helical peptide as a potential HIV-1 inhibitor

1 reference

12 December 2020

Virus budding and the ESCRT pathway

1 reference

12 December 2020

HIV-1 assembly, budding, and maturation

1 reference

12 December 2020

HIV-1 pathogenesis: the virus

1 reference

12 December 2020

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

1 reference

12 December 2020

Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization

1 reference

12 December 2020

Functional role of Alix in HIV-1 replication

1 reference

12 December 2020

Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

1 reference

12 December 2020

Evidence for direct involvement of the capsid protein in HIV infection of nondividing cells

1 reference

12 December 2020

Properties and functions of the nucleocapsid protein in virus assembly

1 reference

12 December 2020

The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation

1 reference

12 December 2020

Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein

1 reference

12 December 2020

Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.

1 reference

12 December 2020

Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins

1 reference

12 December 2020

Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly

1 reference

12 December 2020

Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication

1 reference

12 December 2020

Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain

1 reference

12 December 2020

The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly

1 reference

12 December 2020

New small-molecule inhibitor class targeting human immunodeficiency virus type 1 virion maturation

1 reference

12 December 2020

X-ray structures of the hexameric building block of the HIV capsid

1 reference

12 December 2020

The molecular architecture of HIV.

1 reference

12 December 2020

The interferon-inducible MxB protein inhibits HIV-1 infection.

1 reference

12 December 2020

The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.

1 reference

12 December 2020

Voluntary counseling and testing (VCT) for changing HIV-related risk behavior in developing countries

1 reference

12 December 2020

Extreme genetic fragility of the HIV-1 capsid.

1 reference

12 December 2020

Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus

1 reference

12 December 2020

HIV-1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358

1 reference

12 December 2020

The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor

1 reference

12 December 2020

Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphisms

1 reference

12 December 2020

Host genes important to HIV replication and evolution

1 reference

12 December 2020

Benzamide-based thiolcarbamates: a new class of HIV-1 NCp7 inhibitors

1 reference

12 December 2020

Novel postentry inhibitor of human immunodeficiency virus type 1 replication screened by yeast membrane-associated two-hybrid system

1 reference

12 December 2020

One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.

1 reference

12 December 2020

HIV-1 antiretroviral drug therapy

1 reference

12 December 2020

PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing

1 reference

12 December 2020

Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid protein

1 reference

12 December 2020

The Role of Lipids in Retrovirus Replication

1 reference

12 December 2020

HIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic intervention

1 reference

12 December 2020

Role of lipid rafts in virus replication

1 reference

12 December 2020

Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production

1 reference

12 December 2020

Functional association of cyclophilin A with HIV-1 virions

1 reference

12 December 2020

Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent

1 reference

12 December 2020

New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.

1 reference

12 December 2020

Dual-acting stapled peptides target both HIV-1 entry and assembly

1 reference

12 December 2020

Cell-dependent requirement of human immunodeficiency virus type 1 gp41 cytoplasmic tail for Env incorporation into virions

1 reference

12 December 2020

Roles of Vpr and Vpx in modulating the virus-host cell relationship

1 reference

12 December 2020

Identifiers

DOI

10.1007/82_2015_436

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6941199&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6941199&resulttype=core&format=json

13 May 2020

PubMed publication ID

25731773

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6941199&resulttype=core&format=json