The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments? (Q38166991)

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English	The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?	scientific article

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1 March 2020

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments? (English)

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1 March 2020

Steven B Abramson

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Anne C Bay-Jensen

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A C Bay-Jensen

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M A Karsdal

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P Pastoureau

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C Christiansen

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K Henriksen

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S R Goldring

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V Kraus

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27 November 2013

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1 March 2020

Annals of the Rheumatic Diseases

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1 March 2020

Prospects for disease modification in osteoarthritis.

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21 January 2018

Osteoarthritis: an update with relevance for clinical practice

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21 January 2018

Osteoarthritis: Is it a disease of cartilage or of bone?

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21 January 2018

The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model

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21 January 2018

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

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21 January 2018

Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis.

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21 January 2018

Subchondral bone as a key target for osteoarthritis treatment.

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21 January 2018

Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits.

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21 January 2018

Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?

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21 January 2018

Genetic factors in OA pathogenesis

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21 January 2018

Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone.

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21 January 2018

Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption

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21 January 2018

Structure-modifying agents for osteoarthritis: an update

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21 January 2018

Estrogens, cartilage, and osteoarthritis

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21 January 2018

Body mass index in young men and the risk of subsequent knee and hip osteoarthritis

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21 January 2018

Strategies for the prevention and management of osteoarthritis of the hip and knee

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21 January 2018

Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index

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https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Osteoarthritis severity is sex dependent in a surgical mouse model

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21 January 2018

Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application

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21 January 2018

Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM).

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21 January 2018

Increased metabolism of bone collagen in post-menopausal female osteoporotic femoral heads

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21 January 2018

Do Subchondral Bone Changes Exacerbate or Precede Articular Cartilage Destruction in Osteoarthritis of the Elderly?

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21 January 2018

Obesity and osteoarthritis of the knee: evidence from the National Health and Nutrition Examination Survey (NHANES I).

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21 January 2018

Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis

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21 January 2018

Relative risk factors for osteoporotic fracture: a pilot study of the MEDOS questionnaire

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21 January 2018

Osteoarthritis protects against femoral neck fracture: the MEDOS study experience

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21 January 2018

Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship

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21 January 2018

Osteoarthritis and risk of falls, rates of bone loss, and osteoporotic fractures. Study of Osteoporotic Fractures Research Group

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21 January 2018

Risk factors for progression of lumbar spine disc degeneration: the Chingford Study

1 reference

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21 January 2018

Bone mineral density and knee osteoarthritis in elderly men and women. the framingham study

1 reference

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21 January 2018

Evidence of altered bone turnover, vitamin D and calcium regulation with knee osteoarthritis in female twins.

1 reference

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21 January 2018

The role of bone metabolism in osteoarthritis

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https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy

1 reference

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21 January 2018

Is osteoarthritis a systemic disorder of bone?

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Evidence for altered synthesis of type II collagen in patients with osteoarthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Scintigraphic assessment of osteoarthritis of the knee joint

1 reference

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21 January 2018

Subchondral bone should be the main target for the treatment of pain and disease progression in osteoarthritis.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Osteoarthritis: epidemiology

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21 January 2018

Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression

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21 January 2018

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

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21 January 2018

Bone marrow abnormalities on magnetic resonance imaging are associated with type II collagen degradation in knee osteoarthritis: a three-month longitudinal study

1 reference

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21 January 2018

Bone marrow edema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology

1 reference

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21 January 2018

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Quantitative bone marrow lesion size in osteoarthritic knees correlates with cartilage damage and predicts longitudinal cartilage loss

1 reference

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21 January 2018

The association of bone marrow lesions with pain in knee osteoarthritis

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21 January 2018

Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

1 reference

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21 January 2018

Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys

1 reference

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21 January 2018

Abnormal cancellous bone collagen metabolism in osteoarthritis

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21 January 2018

The relationship of antiresorptive drug use to structural findings and symptoms of knee osteoarthritis

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21 January 2018

Evidence of early subchondral bone changes in the meniscectomized guinea pig. A densitometric study using dual-energy X-ray absorptiometry subregional analysis

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21 January 2018

Fundamental subchondral bone changes in spontaneous knee osteoarthritis

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21 January 2018

Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis

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21 January 2018

The emerging role of Dickkopf-1 in bone biology: is it the main switch controlling bone and joint remodeling?

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21 January 2018

Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients

1 reference

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21 January 2018

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women

1 reference

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21 January 2018

Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis

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21 January 2018

Alterations in periarticular bone and cross talk between subchondral bone and articular cartilage in osteoarthritis

1 reference

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21 January 2018

Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other?

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Are nonresorbing osteoclasts sources of bone anabolic activity?

1 reference

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21 January 2018

Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.

1 reference

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21 January 2018

Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: influence of osteotropic factors

1 reference

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21 January 2018

Chondroitin and glucosamine sulfate in combination decrease the pro-resorptive properties of human osteoarthritis subchondral bone osteoblasts: a basic science study

1 reference

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21 January 2018

Abnormal insulin-like growth factor 1 signaling in human osteoarthritic subchondral bone osteoblasts

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Hyaluronic acid reverses the abnormal synthetic activity of human osteoarthritic subchondral bone osteoblasts

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Endogenous prostaglandin E2 and insulin-like growth factor 1 can modulate the levels of parathyroid hormone receptor in human osteoarthritic osteoblasts

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Abnormal regulation of urokinase plasminogen activator by insulin-like growth factor 1 in human osteoarthritic subchondral osteoblasts

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Osteoblast-like cells from human subchondral osteoarthritic bone demonstrate an altered phenotype in vitro: possible role in subchondral bone sclerosis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Subchondral bone and osteoarthritis: biological and cellular aspects

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Regulation of subchondral bone osteoblast metabolism by cyclic compression

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Runx2- and histone deacetylase 3-mediated repression is relieved in differentiating human osteoblast cells to allow high bone sialoprotein expression

1 reference

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21 January 2018

Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts.

1 reference

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21 January 2018

Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees

1 reference

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21 January 2018

Evidence for the dysregulated expression of TWIST1, TGFβ1 and SMAD3 in differentiating osteoblasts from primary hip osteoarthritis patients

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Elevated Dickkopf-2 levels contribute to the abnormal phenotype of human osteoarthritic osteoblasts

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Expression of vascular endothelial growth factor in normal, osteoarthritic and osteoporotic osteoblasts

1 reference

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21 January 2018

RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Phenotypic characterization of osteoarthritic osteocytes from the sclerotic zones: a possible pathological role in subchondral bone sclerosis.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Osteoarthritis cartilage histopathology: grading and staging.

1 reference

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21 January 2018

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

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21 January 2018

Osteoclast differentiation and activation

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Mechanisms of Disease: the link between RANKL and arthritic bone disease

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21 January 2018

Analysis of the kinetics of osteoclastogenesis in arthritic rats

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

RANKL is a marker and mediator of local and systemic bone loss in two rat models of inflammatory arthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients

1 reference

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21 January 2018

Should subchondral bone turnover be targeted when treating osteoarthritis?

1 reference

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21 January 2018

Epigenomic and microRNA-mediated regulation in cartilage development, homeostasis, and osteoarthritis

1 reference

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21 January 2018

TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Monocytes from patients with osteoarthritis display increased osteoclastogenesis and bone resorption: the In Vitro Osteoclast Differentiation in Arthritis study.

1 reference

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21 January 2018

Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones

1 reference

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21 January 2018

How proteases regulate bone morphogenesis

1 reference

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21 January 2018

Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice.

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21 January 2018

Dissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strength

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21 January 2018

Osteoclast Activity and Subtypes as a Function of Physiology and Pathology—Implications for Future Treatments of Osteoporosis

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21 January 2018

Radiological, biochemical and hereditary evidence of two types of autosomal dominant osteopetrosis

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21 January 2018

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!).

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21 January 2018

Prognostic biomarkers in osteoarthritis

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https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis

1 reference

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21 January 2018

Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations

1 reference

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21 January 2018

Improved flow cytometric assessment reveals distinct microvesicle (cell-derived microparticle) signatures in joint diseases

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Different chemokines are expressed in human arthritic bone biopsies: IFN-gamma and IL-6 differently modulate IL-8, MCP-1 and rantes production by arthritic osteoblasts

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Efficacy of zoledronic acid in treatment of teoarthritis is dependent on the disease progression stage in rat medial meniscal tear model

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Inhibition of bone resorption blunts osteoarthritis in mice with high bone remodelling.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Effects of risedronate on osteoarthritis of the knee

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthri

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

A 2 yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patients

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the Knee Osteoarthritis Structural Arthritis randomized clinical trial

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Associations of CTX-II with biochemical markers of bone turnover raise questions on its tissue origin: data from CHECK, a cohort study of early osteoarthritis.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21 months by MRI.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Bone resorption by isolated human osteoclasts in vitro: effects of calcitonin.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Calcitonin: a drug of the past or for the future? Physiologic inhibition of bone resorption while sustaining osteoclast numbers improves bone quality

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Calcitonin is involved in cartilage homeostasis: is calcitonin a treatment for OA?

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Identification of the calcitonin receptor in osteoarthritic chondrocytes

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Positive Regulation of Endochondral Cartilage Growth by Perichondrial and Periosteal Calcitonin

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Effect of calcitonin on glycosaminoglycan synthesis by embryo calf bone cells in vitro.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Oral salmon calcitonin reduces cartilage and bone pathology in an osteoarthritis rat model with increased subchondral bone turnover

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Calcitonin delays the progress of early-stage mechanically induced osteoarthritis. In vivo, prospective study.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

An intra-articular salmon calcitonin-based nanocomplex reduces experimental inflammatory arthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Lessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trials

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Safety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnover

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Oral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Influence of food intake on the bioavailability and efficacy of oral calcitonin

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Biochemical markers identify influences on bone and cartilage degradation in osteoarthritis--the effect of sex, Kellgren-Lawrence (KL) score, body mass index (BMI), oral salmon calcitonin (sCT) treatment and diurnal variation

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Inhibition of cathepsin K for treatment of osteoporosis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Cathepsin K inhibition reduces CTXII levels and joint pain in the guinea pig model of spontaneous osteoarthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Down-regulation of cathepsin K in synovium leads to progression of osteoarthritis in rabbits.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Evidence to suggest that cathepsin K degrades articular cartilage in naturally occurring equine osteoarthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Endogenous sex steroid levels in women with generalised osteoarthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Estradiol and its metabolites and their association with knee osteoarthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

The incidence and natural history of knee osteoarthritis in the elderly, the framingham osteoarthritis study

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

The effects of estrogen on osteoarthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

A microarray analysis of full depth knee cartilage of ovariectomized rats

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Immunohistochemical detection of estrogen receptor alpha in articular chondrocytes from cows, pigs and humans: in situ and in vitro results

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

The pathogenesis of osteoarthritis involves bone, cartilage and synovial inflammation: may estrogen be a magic bullet?

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Pharmacology of arthralgia with estrogen deprivation

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Treatment of climacteric complaints with Org OD 14: a comparative study with oestradiol valerate and placebo

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Clinical effects of strontium ranelate in women with postmenopausal osteoporosis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Strontium ranelate reduces the risk of vertebral fractures in patients with osteopenia

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Vertebral fracture risk reduction with strontium ranelate in women with postmenopausal osteoporosis is independent of baseline risk factors

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

In vitro effects of strontium ranelate on the extracellular calcium-sensing receptor

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Effects of strontium ranelate on spinal osteoarthritis progression.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Strontium ranelate increases cartilage matrix formation

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1β in the synovium

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind, randomised placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

The role of bone in the treatment of osteoarthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Early radiographic features in patients with anterior cruciate ligament rupture

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Modification of articular cartilage and subchondral bone pathology in an ovine meniscectomy model of osteoarthritis by avocado and soya unsaponifiables (ASU).

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Subchondral bone changes in hand and knee osteoarthritis detected by radiography

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

PTHrP promotes chondrogenesis and suppresses hypertrophy from both bone marrow-derived and adipose tissue-derived MSCs

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Developmental regulation of the growth plate

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Parathyroid hormone-related protein regulates proliferation of condylar hypertrophic chondrocytes.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation.

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Fracture risk before and after total hip replacement in patients with osteoarthritis: Potential benefits of bisphosphonate use

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

The predictive role of scintigraphy in radiographic osteoarthritis of the hand

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Effects of denosumab on bone turnover markers in postmenopausal osteoporosis

1 reference

https://api.crossref.org/works/10.1136%2FANNRHEUMDIS-2013-204111

21 January 2018

Identifiers

10.1136/ANNRHEUMDIS-2013-204111

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285494%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24285494%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

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