The molecular biology of head and neck cancer (Q37821229)

23 August 2017

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title

The molecular biology of head and neck cancer (English)

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23 August 2017

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C René Leemans

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23 August 2017

author name string

Boudewijn J M Braakhuis

series ordinal

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23 August 2017

Ruud H Brakenhoff

series ordinal

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23 August 2017

language of work or name

English

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publication date

16 December 2010

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23 August 2017

published in

Nature Reviews Cancer

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23 August 2017

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23 August 2017

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23 August 2017

page(s)

9-22

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Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world

23 August 2017

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Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression

31 March 2020

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Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high-risk head and neck squamous cell carcinoma.

31 March 2020

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31 March 2020

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Prevalence and expression of human papillomavirus in tonsillar carcinomas, indicating a possible viral etiology

31 March 2020

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Evidence for a causal association between human papillomavirus and a subset of head and neck cancers

31 March 2020

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31 March 2020

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The clinical relevance of human papillomavirus testing: relationship between analytical and clinical sensitivity

31 March 2020

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Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas

31 March 2020

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Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control.

31 March 2020

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Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus

31 March 2020

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Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus

31 March 2020

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Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma.

31 March 2020

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A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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TP53 mutations and survival in squamous-cell carcinoma of the head and neck.

31 March 2020

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Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck

31 March 2020

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Natural history of potentially malignant oral lesions and conditions: an overview of the literature

31 March 2020

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Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management

31 March 2020

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Interventions for treating oral leukoplakia

31 March 2020

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Chemoprevention of squamous cell carcinoma of the head and neck

31 March 2020

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Evaluation of cornulin, keratin 4, keratin 13 expression and grade of dysplasia for predicting malignant progression of oral leukoplakia

31 March 2020

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Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment

31 March 2020

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DNA ploidy analysis by image cytometry helps to identify oral epithelial dysplasias with a high risk of malignant progression

31 March 2020

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Salivary analysis of oral cancer biomarkers

31 March 2020

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A noninvasive genetic screening test to detect oral preneoplastic lesions

31 March 2020

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Screening for oral precancer with noninvasive genetic cytology

31 March 2020

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Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin

31 March 2020

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Comparative molecular and histological grading of epithelial dysplasia of the oral cavity and the oropharynx

31 March 2020

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Genetic instability in epithelial tissues at risk for cancer

31 March 2020

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Genetically altered fields as origin of locally recurrent head and neck cancer: a retrospective study

31 March 2020

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Proteomic analysis reveals successive aberrations in protein expression from healthy mucosa to invasive head and neck cancer.

31 March 2020

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Differential Proteomics Identifies Protein Biomarkers That Predict Local Relapse of Head and Neck Squamous Cell Carcinomas

31 March 2020

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Mutated p53 as a molecular marker for the diagnosis of head and neck cancer

31 March 2020

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Frequent clones of p53-mutated keratinocytes in normal human skin

31 March 2020

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Clinical implications and utility of field cancerization

31 March 2020

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Genomic instability--an evolving hallmark of cancer

31 March 2020

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Unraveling the chromosomal aberrations of head and neck squamous cell carcinoma: a review

31 March 2020

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Chromosomal aberrations in squamous cell carcinomas of the upper aerodigestive tract: biologic insights and clinical opportunities

31 March 2020

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Molecular techniques and genetic alterations in head and neck cancer

31 March 2020

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Modern criteria to establish human cancer etiology.

31 March 2020

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Cell-cycle checkpoints and cancer

31 March 2020

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Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism

31 March 2020

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A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status

31 March 2020

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Amplicon mapping and expression profiling identify the Fas-associated death domain gene as a new driver in the 11q13.3 amplicon in laryngeal/pharyngeal cancer

31 March 2020

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

31 March 2020

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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

31 March 2020

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ERBB receptors and cancer: the complexity of targeted inhibitors

31 March 2020

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Nuclear localization of EGF receptor and its potential new role as a transcription factor

31 March 2020

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Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

31 March 2020

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Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis

31 March 2020

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Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas

31 March 2020

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Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma

31 March 2020

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Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck

31 March 2020

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Phosphoproteomics strategies for the functional analysis of signal transduction

31 March 2020

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Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck

31 March 2020

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Low incidence of mutations in EGFR kinase domain in Caucasian patients with head and neck squamous cell carcinoma

31 March 2020

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Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

31 March 2020

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Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting

31 March 2020

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Gene amplification and overexpression of EGF receptor in squamous cell carcinomas of the head and neck

31 March 2020

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Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer

31 March 2020

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Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma

31 March 2020

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Showering c-MET-dependent cancers with drugs

31 March 2020

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The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma

31 March 2020

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HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer

31 March 2020

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Mutation and downregulation of the transforming growth factor beta type II receptor gene in primary squamous cell carcinomas of the head and neck

31 March 2020

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Attenuated type II TGF-beta receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination

31 March 2020

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Disruption of transforming growth factor beta-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4.

31 March 2020

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Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection

31 March 2020

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Nuclear factor-kappaB in cancer development and progression

31 March 2020

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Integrating cell-signalling pathways with NF-kappaB and IKK function

31 March 2020

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Attenuated transforming growth factor beta signaling promotes nuclear factor-kappaB activation in head and neck cancer.

31 March 2020

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

31 March 2020

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PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma

31 March 2020

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PIK3CA mutations in head and neck squamous cell carcinoma

31 March 2020

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Genomic gain of PIK3CA and increased expression of p110alpha are associated with progression of dysplasia into invasive squamous cell carcinoma.

31 March 2020

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Dissecting the metastatic cascade

31 March 2020

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Matrix metalloproteases in head and neck cancer

31 March 2020

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Transcript map of the 8p23 putative tumor suppressor region

31 March 2020

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Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx

31 March 2020

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Localization of a putative tumor suppressor gene in the sub-telomeric region of chromosome 8p

31 March 2020

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CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues

31 March 2020

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An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas

31 March 2020

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Epithelial-mesenchymal transitions in tumour progression

31 March 2020

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TGFbeta signalling: a complex web in cancer progression

31 March 2020

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Role of angiogenesis in tumor growth and metastasis

31 March 2020

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31 March 2020

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Prognostic significance of vascular endothelial growth factor immunohistochemical expression in head and neck squamous cell carcinoma: a meta-analysis

31 March 2020

1 reference

Prognostic significance of vascular endothelial growth factor in squamous cell carcinomas of the tonsil in relation to human papillomavirus status and epidermal growth factor receptor.

31 March 2020

1 reference

FHIT gene alterations in head and neck squamous cell carcinomas

31 March 2020

1 reference

AIS is an oncogene amplified in squamous cell carcinoma

31 March 2020

1 reference

p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis

31 March 2020

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MYC amplification in squamous cell carcinomas of the head and neck

31 March 2020

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Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma

31 March 2020

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MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma

31 March 2020

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Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinoma

31 March 2020

1 reference

Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma

31 March 2020

1 reference

Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial

31 March 2020

1 reference

Multistep laryngeal carcinogenesis helps our understanding of the field cancerisation phenomenon: a review

31 March 2020

1 reference

Fluorescence visualization detection of field alterations in tumor margins of oral cancer patients

31 March 2020

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Objective detection and delineation of oral neoplasia using autofluorescence imaging

31 March 2020

1 reference

Second primary tumors and field cancerization in oral and oropharyngeal cancer: molecular techniques provide new insights and definitions

31 March 2020

1 reference

TGF-beta signaling in tumor suppression and cancer progression

31 March 2020

1 reference

Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States

31 March 2020

1 reference

Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma?

31 March 2020

1 reference

Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma

31 March 2020

1 reference

Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study.

31 March 2020

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Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas.

31 March 2020

1 reference

Frequent 3p allele loss and epigenetic inactivation of the RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma

31 March 2020

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The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers

31 March 2020

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Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck

31 March 2020

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Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas

31 March 2020

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Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.

31 March 2020

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Genomic organization, chromosomal localization, and independent expression of human cyclin D genes

31 March 2020

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Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma.

31 March 2020

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Genome-wide analyses on loss of heterozygosity in head and neck squamous cell carcinomas

31 March 2020

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Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas

31 March 2020

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12 December 2020

Genetic classification of oral and oropharyngeal carcinomas identifies subgroups with a different prognosis.

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12 December 2020

A case-control study confirms that microsatellite assay can identify patients at risk of developing oral squamous cell carcinoma within a field of cancerization

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12 December 2020

A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications

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12 December 2020

Multicentric origin of intraoral carcinoma

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12 December 2020

Frequent p53 mutations in head and neck cancer

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12 December 2020

Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31

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12 December 2020

Loss of heterozygosity at 9p and p53 immunopositivity in surgical margins predict local relapse in head and neck squamous cell carcinoma.

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12 December 2020

Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.

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12 December 2020

Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas

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12 December 2020

Patterns of chromosomal alterations in metastasizing and nonmetastasizing primary head and neck carcinomas

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12 December 2020

A simple specific pattern of chromosomal aberrations at early stages of head and neck squamous cell carcinomas: PIK3CA but not p63 gene as a likely target of 3q26-qter gains

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12 December 2020

Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer.

1 reference

12 December 2020

Telomerase activity exclusively in cervical carcinomas and a subset of cervical intraepithelial neoplasia grade III lesions: strong association with elevated messenger RNA levels of its catalytic subunit and high-risk human papillomavirus DNA

1 reference

12 December 2020

Persistence of genetically altered fields in head and neck cancer patients: biological and clinical implications.

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12 December 2020

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

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12 December 2020

Genetic progression model for head and neck cancer: implications for field cancerization

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12 December 2020

High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma

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12 December 2020

Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia.

1 reference

12 December 2020

Is the p53 inactivation frequency in squamous cell carcinomas of the head and neck underestimated? Analysis of p53 exons 2-11 and human papillomavirus 16/18 E6 transcripts in 123 unselected tumor specimens.

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12 December 2020

Identifiers

DOI

10.1038/NRC2982

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23 August 2017

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