Online electrochemistry/mass spectrometry in drug metabolism studies: principles and applications (Q37724884)

22 August 2017

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title

Online electrochemistry/mass spectrometry in drug metabolism studies: principles and applications (English)

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22 August 2017

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Anne Baumann

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22 August 2017

Uwe Karst

series ordinal

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22 August 2017

language of work or name

English

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publication date

1 June 2010

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Expert Opinion on Drug Metabolism & Toxicology

22 August 2017

published in

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22 August 2017

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22 August 2017

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22 August 2017

page(s)

715-731

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Lessons from 60 years of pharmaceutical innovation

22 August 2017

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Free radicals in the physiological control of cell function

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Oxyradicals and DNA damage

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On-line electrochemistry--MS and related techniques

21 January 2018

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An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

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Human hepatocytes as a tool for studying toxicity and drug metabolism.

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Liver tissue engineering in the evaluation of drug safety

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New analytical strategies in studying drug metabolism

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Recent advances in the applications of radioisotopes in drug metabolism, toxicology and pharmacokinetics

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The use of radiolabeled compounds for ADME studies in discovery and exploratory development

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Application of mass spectrometry for metabolite identification

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Biomolecular NMR: a chaperone to drug discovery

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Rapid detection and characterization of reactive drug metabolites in vitro using several isotope-labeled trapping agents and ultra-performance liquid chromatography/time-of-flight mass spectrometry

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A Human Drug Metabolism Database: Potential Roles in the Quantitative Predictions of Drug Metabolism and Metabolism-Related Drug-Drug Interactions

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Human P450s in the metabolism of drugs: molecular modelling of enzyme-substrate interactions

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Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds

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Strategies for the liquid chromatographic-mass spectrometric analysis of non-polar compounds

21 January 2018

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On-line liquid chromatography and circular dichroism detection of stereo-isomers of alpha-tocopherol derivatives generated by an electrochemical reaction

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Electrochemically assisted Fenton reaction: reaction of hydroxyl radicals with xenobiotics followed by on-line analysis with high-performance liquid chromatography/tandem mass spectrometry

21 January 2018

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Novel metabolites of amodiaquine formed by CYP1A1 and CYP1B1: structure elucidation using electrochemistry, mass spectrometry, and NMR.

21 January 2018

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Metabolic studies of tetrazepam based on electrochemical simulation in comparison to in vivo and in vitro methods

21 January 2018

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A microfluidic chip for electrochemical conversions in drug metabolism studies.

21 January 2018

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On-line coupling of a microelectrode array equipped poly(dimethylsiloxane) microchip with an integrated graphite electrospray emitter for electrospray ionisation mass spectrometry

21 January 2018

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Controlling analyte electrochemistry in an electrospray ion source with a three-electrode emitter cell.

21 January 2018

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Efficient analyte oxidation in an electrospray ion source using a porous flow-through electrode emitter

21 January 2018

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Study and application of a controlled-potential electrochemistry-electrospray emitter for electrospray mass spectrometry

21 January 2018

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Expanded electrochemical capabilities of the electrospray ion source using porous flow-through electrodes as the upstream ground and emitter high-voltage contact

21 January 2018

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Functional electrospray emitters

21 January 2018

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Cytochrome p450 and chemical toxicology

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The ins and outs of cytochrome P450s.

21 January 2018

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Comparison between electrochemistry/mass spectrometry and cytochrome P450 catalyzed oxidation reactions

21 January 2018

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Model electrochemical-mass spectrometric studies of the cytochrome P450-catalyzed oxidations of cyclic tertiary allylamines

21 January 2018

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Electrochemical mass spectrometric studies on 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine

21 January 2018

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The role of reactive oxygen and nitrogen species in cellular iron metabolism

21 January 2018

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Quantification of electrochemically generated iodine-containing metabolites using inductively coupled plasma mass spectrometry

21 January 2018

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Electrochemistry meets enzymes: instrumental on-line simulation of oxidative and conjugative metabolism reactions of toremifene

21 January 2018

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Prediction of clozapine metabolism by on-line electrochemistry/liquid chromatography/mass spectrometry

21 January 2018

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On-line electrochemistry/liquid chromatography/mass spectrometry for the simulation of pesticide metabolism

21 January 2018

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Bioactivation of diclofenac in vitro and in vivo: correlation to electrochemical studies

21 January 2018

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Electrochemical oxidation of troglitazone: identification and characterization of the major reactive metabolite in liver microsomes.

21 January 2018

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Production of a reactive metabolite of troglitazone by electrochemical oxidation performed in nonaqueous medium.

21 January 2018

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Generation of mass tags by the inherent electrochemistry of electrospray for protein mass spectrometry

21 January 2018

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Electrochemically initiated tagging of thiols using an electrospray ionization based liquid microjunction surface sampling probe two-electrode cell

21 January 2018

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Successful preparation of metabolite of troglitazone by in-flow electrochemical reaction on coulometric electrode

21 January 2018

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Electrochemical generation of electrophilic drug metabolites: characterization of amodiaquine quinoneimine and cysteinyl conjugates by MS, IR, and NMR.

21 January 2018

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Use of an electrochemically synthesised metabolite of a selective androgen receptor modulator for mass spectrometry-based sports drug testing

21 January 2018

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Liquid chromatography coupled with inductively coupled plasma mass spectrometry in the pharmaceutical industry: selected examples

21 January 2018

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Anodic oxidation of ifosfamide and cyclophosphamide: a biomimetic metabolism model of the oxazaphosphorinane anticancer drugs

21 January 2018

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10.1517/17425251003713527

21 January 2018

Identifiers

DOI

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22 August 2017

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