Zinc in the physiology and pathology of the CNS. (Q37614216)

21 August 2017

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title

Zinc in the physiology and pathology of the CNS. (English)

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21 August 2017

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Pierre Paoletti

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Stefano L Sensi

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Ashley I Bush

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Israel Sekler

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21 August 2017

language of work or name

English

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publication date

14 October 2009

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Nature Reviews Neuroscience

21 August 2017

published in

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

780-791

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Biochemical properties of vacuolar zinc transport systems of Saccharomyces cerevisiae

21 August 2017

cites work

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Mild acidosis enhances AMPA receptor-mediated intracellular zinc mobilization in cortical neurons.

21 January 2018

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The neurobiology of zinc in health and disease

21 January 2018

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Zinc distribution and expression pattern of ZnT3 in mouse brain.

31 March 2020

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Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles

31 March 2020

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AMPA/kainate receptor-triggered Zn2+ entry into cortical neurons induces mitochondrial Zn2+ uptake and persistent mitochondrial dysfunction.

31 March 2020

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Zinquin identifies subcellular compartmentalization of zinc in cortical neurons. Relation to the trafficking of zinc and the mitochondrial compartment

31 March 2020

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Zinc and 4-hydroxy-2-nonenal mediate lysosomal membrane permeabilization induced by H2O2 in cultured hippocampal neurons.

31 March 2020

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Genetically encoded sensors to elucidate spatial distribution of cellular zinc

31 March 2020

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Zn2+ ions: modulators of excitatory and inhibitory synaptic activity.

31 March 2020

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Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus

31 March 2020

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Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat.

31 March 2020

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The role of zinc in selective neuronal death after transient global cerebral ischemia

31 March 2020

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Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury

31 March 2020

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Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin.

31 March 2020

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Induction of Neuronal Apoptosis by Thiol Oxidation

31 March 2020

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Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporter

31 March 2020

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Kinetic study of the antiport mechanism of an Escherichia coli zinc transporter, ZitB.

31 March 2020

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Structure of the zinc transporter YiiP

31 March 2020

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ZnT-3, a putative transporter of zinc into synaptic vesicles

31 March 2020

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Endogenous zinc inhibits GABA(A) receptors in a hippocampal pathway

31 March 2020

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Inhibitory zinc-enriched terminals in the mouse cerebellum: double-immunohistochemistry for zinc transporter 3 and glutamate decarboxylase

31 March 2020

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Lack of vesicular zinc in mossy fibers does not affect synaptic excitability of CA3 pyramidal cells in zinc transporter 3 knockout mice

31 March 2020

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The hippocampal region of rats and mice after a single i.p. dose of clioquinol: loss of synaptic zinc, cell death and c-Fos induction

31 March 2020

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Chelation of synaptic zinc induces overexcitation in the hilar mossy cells of the rat hippocampus

31 March 2020

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Susceptibility to kainate-induced seizures under dietary zinc deficiency

31 March 2020

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Changes in the vesicular zinc pattern following traumatic brain injury

31 March 2020

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Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc

31 March 2020

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ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc.

31 March 2020

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Expression of zinc transporter gene, ZnT-1, is induced after transient forebrain ischemia in the gerbil.

31 March 2020

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The increase in zinc levels and upregulation of zinc transporters are mediated by nitric oxide in the cerebral cortex after transient ischemia in the rat.

31 March 2020

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Silencing of ZnT-1 expression enhances heavy metal influx and toxicity

31 March 2020

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Silencing of ZnT1 reduces Zn2+ efflux in cultured cortical neurons

31 March 2020

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A role for ZnT-1 in regulating cellular cation influx

31 March 2020

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Measurement of intracellular free zinc in living cortical neurons: routes of entry

31 March 2020

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A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells.

31 March 2020

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Mechanisms of Zn2+ efflux in cultured cortical neurons

31 March 2020

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Functional expression of the human hZIP2 zinc transporter

31 March 2020

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Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters.

31 March 2020

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The adaptive response to dietary zinc in mice involves the differential cellular localization and zinc regulation of the zinc transporters ZIP4 and ZIP5

31 March 2020

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Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations

31 March 2020

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Generation and characterization of mice lacking the zinc uptake transporter ZIP3.

31 March 2020

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Zinc at glutamatergic synapses.

31 March 2020

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High-affinity zinc inhibition of NMDA NR1-NR2A receptors

31 March 2020

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The micromolar zinc-binding domain on the NMDA receptor subunit NR2B.

31 March 2020

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Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission

31 March 2020

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Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse

31 March 2020

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Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse.

31 March 2020

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Synaptically released zinc gates long-term potentiation in fear conditioning pathways.

31 March 2020

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Zinc-mediated transactivation of TrkB potentiates the hippocampal mossy fiber-CA3 pyramid synapse

31 March 2020

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A startling role for synaptic zinc.

31 March 2020

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Nonvesicular release of neurotransmitter.

31 March 2020

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The actions of synaptically released zinc at hippocampal mossy fiber synapses.

31 March 2020

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Synaptically-released zinc inhibits N-methyl-D-aspartate receptor activation at recurrent mossy fiber synapses.

31 March 2020

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pH-dependent inhibition of kainate receptors by zinc

31 March 2020

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Boutons containing vesicular zinc define a subpopulation of synapses with low AMPAR content in rat hippocampus

31 March 2020

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Zinc and cortical plasticity.

31 March 2020

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Activation of the Trk signaling pathway by extracellular zinc. Role of metalloproteinases

31 March 2020

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Intracellular zinc elevation measured with a "calcium-specific" indicator during ischemia and reperfusion in rat hippocampus: a question on calcium overload.

31 March 2020

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Capacitative Ca2+ entry is closely linked to the filling state of internal Ca2+ stores: a study using simultaneous measurements of ICRAC and intraluminal [Ca2+]

31 March 2020

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Intracellular Zn2+ accumulation contributes to synaptic failure, mitochondrial depolarization, and cell death in an acute slice oxygen-glucose deprivation model of ischemia.

31 March 2020

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Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators

31 March 2020

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Zn(2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria.

31 March 2020

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Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels

31 March 2020

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Mitochondrial membrane permeabilization in neuronal injury

31 March 2020

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Zinc translocation accelerates infarction after mild transient focal ischemia.

31 March 2020

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Blockade of Ca2+-permeable AMPA/kainate channels decreases oxygen-glucose deprivation-induced Zn2+ accumulation and neuronal loss in hippocampal pyramidal neurons.

31 March 2020

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Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death

31 March 2020

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Direct visualization of mitochondrial zinc accumulation reveals uniporter-dependent and -independent transport mechanisms.

31 March 2020

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Modulation of mitochondrial function by endogenous Zn2+ pools.

31 March 2020

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Mediation of neuronal apoptosis by Kv2.1-encoded potassium channels.

31 March 2020

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Intracellular zinc inhibits KCC2 transporter activity

31 March 2020

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Zinc irreversibly damages major enzymes of energy production and antioxidant defense prior to mitochondrial permeability transition.

31 March 2020

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Zinc causes loss of membrane potential and elevates reactive oxygen species in rat brain mitochondria

31 March 2020

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Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

31 March 2020

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Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration.

31 March 2020

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Zinc-dependent multi-conductance channel activity in mitochondria isolated from ischemic brain

31 March 2020

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Zn2+ inhibits mitochondrial movement in neurons by phosphatidylinositol 3-kinase activation

31 March 2020

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The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly(ADP-ribose) polymerase activation and cell death in cortical culture

31 March 2020

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Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis

31 March 2020

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Protection by pyruvate against transient forebrain ischemia in rats.

31 March 2020

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

31 March 2020

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Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway

31 March 2020

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Sequential release of nitric oxide, zinc, and superoxide in hypoglycemic neuronal death

31 March 2020

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Oxidative injury triggers autophagy in astrocytes: the role of endogenous zinc

31 March 2020

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Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium.

31 March 2020

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Zn2+ current is mediated by voltage-gated Ca2+ channels and enhanced by extracellular acidity in mouse cortical neurones

31 March 2020

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Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons

31 March 2020

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Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

31 March 2020

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Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH.

31 March 2020

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Extracellular zinc protects against acidosis-induced injury of cells expressing Ca2+-permeable acid-sensing ion channels

31 March 2020

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Elevated intracellular zinc and altered proton homeostasis in forebrain neurons.

31 March 2020

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Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat

31 March 2020

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Induction of an immediate early gene egr-1 by zinc through extracellular signal-regulated kinase activation in cortical culture: its role in zinc-induced neuronal death

31 March 2020

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Essential role for zinc-triggered p75NTR activation in preconditioning neuroprotection.

31 March 2020

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Zinc treatment induces cortical brain-derived neurotrophic factor gene expression

31 March 2020

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Rapid induction of Alzheimer A beta amyloid formation by zinc.

31 March 2020

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Metal ions differentially influence the aggregation and deposition of Alzheimer's beta-amyloid on a solid template

31 March 2020

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Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species.

31 March 2020

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

31 March 2020

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Redox-active iron mediates amyloid-beta toxicity

31 March 2020

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

31 March 2020

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Monitoring the earliest amyloid-beta oligomers via quantized photobleaching of dye-labeled peptides

31 March 2020

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A specific amyloid-beta protein assembly in the brain impairs memory

31 March 2020

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Selective destabilization of soluble amyloid β oligomers by divalent metal ions

31 March 2020

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Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

31 March 2020

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Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain

31 March 2020

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Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease.

31 March 2020

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Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain

31 March 2020

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Altered expression and distribution of zinc transporters in APP/PS1 transgenic mouse brain

31 March 2020

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A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.

31 March 2020

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Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

31 March 2020

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Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging

31 March 2020

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Metal swap between Zn7-metallothionein-3 and amyloid-beta-Cu protects against amyloid-beta toxicity.

31 March 2020

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Altered oxidant-mediated intraneuronal zinc mobilization in a triple transgenic mouse model of Alzheimer's disease.

31 March 2020

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Stimulation-induced uptake and release of zinc in hippocampal slices

31 March 2020

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Drug Development Based on the Metals Hypothesis of Alzheimer's Disease

31 March 2020

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Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid

31 March 2020

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Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material

31 March 2020

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Copper, iron and zinc in Alzheimer's disease senile plaques

31 March 2020

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Radioiodinated clioquinol as a biomarker for beta-amyloid: Zn complexes in Alzheimer's disease

31 March 2020

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Elevated cortical zinc in Alzheimer disease

31 March 2020

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4-Hydroxynonenal disrupts zinc export in primary rat cortical cells

31 March 2020

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Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency

31 March 2020

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Zinc homeostasis in the brain of adult rats fed zinc-deficient diet

31 March 2020

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Zinc deficiency is associated with increased brain zinc import and LIV-1 expression and decreased ZnT-1 expression in neonatal rats

31 March 2020

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A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease

31 March 2020

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Zinc induces neurofilament phosphorylation independent of p70 S6 kinase in N2a cells

31 March 2020

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Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

31 March 2020

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

31 March 2020

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Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron

31 March 2020

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Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology

31 March 2020

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

31 March 2020

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

31 March 2020

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Insights into Zn2+ homeostasis in neurons from experimental and modeling studies

31 March 2020

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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

31 March 2020

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The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice

31 March 2020

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The self-tuning neuron: synaptic scaling of excitatory synapses

31 March 2020

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Release of endogenous Zn2+ from brain tissue during activity

31 March 2020

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Imaging synaptic zinc: promises and perils

31 March 2020

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Excitation-transcription coupling mediated by zinc influx through voltage-dependent calcium channels

31 March 2020

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Ratiometric-pericam-mt, a novel tool to evaluate intramitochondrial zinc.

31 March 2020

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Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density

31 March 2020

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An architectural framework that may lie at the core of the postsynaptic density

31 March 2020

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A role for zinc in postsynaptic density asSAMbly and plasticity?

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRN2734

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21 August 2017

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