Chapter 12. The use of receptor homology modeling to facilitate the design of selective chemokine receptor antagonists (Q37500718)

20 August 2017

title

Chapter 12. The use of receptor homology modeling to facilitate the design of selective chemokine receptor antagonists (English)

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20 August 2017

Percy H Carter

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20 August 2017

Andrew J Tebben

series ordinal

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20 August 2017

language of work or name

English

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publication date

1 January 2009

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20 August 2017

published in

Methods in Enzymology

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20 August 2017

volume

461

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20 August 2017

page(s)

249-279

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Allosteric inhibitors of chemoattractant receptors: opportunities and pitfalls

20 August 2017

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Pharmacological profile of JNJ-27141491 [(S)-3-[3,4-difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl acid methyl ester], as a noncompetitive and orally active antagonist of the human chemokine receptor CCR2.

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Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.

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Identification of the hydrophobic ligand binding pocket of the S1P1 receptor

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Site-directed mutagenesis of CCR2 identified amino acid residues in transmembrane helices 1, 2, and 7 important for MCP-1 binding and biological functions.

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7 January 2021

Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry

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7 January 2021

Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation.

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7 January 2021

Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors

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7 January 2021

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Identifiers

DOI

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20 August 2017

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