Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse. (Q37490449)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27807175%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

title

Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse (English)

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26 March 2020

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26 March 2020

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26 March 2020

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26 March 2020

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26 March 2020

Douglas R Cavener

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26 March 2020

Nicolò Musner

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26 March 2020

Maurizio D'Antonio

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26 March 2020

M Laura Feltri

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26 March 2020

language of work or name

English

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publication date

1 November 2016

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26 March 2020

published in

Journal of Neuroscience

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26 March 2020

volume

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issue

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26 March 2020

page(s)

11350-11361

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describes a project that uses

26 March 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

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Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy

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PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

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Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice

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TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

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Wolcott-Rallison syndrome is the most common genetic cause of permanent neonatal diabetes in consanguineous families

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Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

23 August 2017

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Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation

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23 August 2017

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23 August 2017

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23 August 2017

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

23 August 2017

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23 August 2017

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

23 August 2017

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

23 August 2017

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23 August 2017

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

23 August 2017

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ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

23 August 2017

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Perk is essential for translational regulation and cell survival during the unfolded protein response

23 August 2017

1 reference

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A regulatory link between ER-associated protein degradation and the unfolded-protein response

23 August 2017

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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

23 August 2017

1 reference

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

23 August 2017

1 reference

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CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

Deletion of the serine 34 codon from the major peripheral myelin protein P0 gene in Charcot-Marie-Tooth disease type 1B

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

Targeting the unfolded protein response in disease.

23 August 2017

1 reference

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Endoplasmic reticulum (ER) chaperone regulation and survival of cells compensating for deficiency in the ER stress response kinase, PERK

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

Ablation of the UPR-mediator CHOP restores motor function and reduces demyelination in Charcot-Marie-Tooth 1B mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.

2 September 2018

1 reference

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Alterations in an IRE1-RNA complex in the mammalian unfolded protein response.

2 September 2018

1 reference

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P(0) glycoprotein overexpression causes congenital hypomyelination of peripheral nerves

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

P0-Cre transgenic mice for inactivation of adhesion molecules in Schwann cells

2 September 2018

1 reference

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Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

Different Intracellular Pathomechanisms Produce Diverse Myelin Protein Zero Neuropathies in Transgenic Mice

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5148247

Beta 4 integrin and other Schwann cell markers in axonal neuropathy

3 December 2018

1 reference

12 December 2020

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

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12 December 2020

Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells

1 reference

12 December 2020

Autopsy findings in the Wolcott-Rallison syndrome

1 reference

12 December 2020

A time-dependent phase shift in the mammalian unfolded protein response

1 reference

12 December 2020

10.1523/JNEUROSCI.1637-16.2016

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27807175%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27807175%20AND%20SRC:MED&resulttype=core&format=json

26 March 2020

PubMed publication ID

27807175

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27807175%20AND%20SRC:MED&resulttype=core&format=json