Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs (Q36716750)

15 August 2017

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title

Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs (English)

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15 August 2017

Luis M Schang

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15 August 2017

Mireille R St Vincent

series ordinal

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15 August 2017

Jonathan J Lacasse

series ordinal

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15 August 2017

publication date

1 January 2006

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Antiviral Chemistry & Chemotherapy

15 August 2017

published in

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

293-320

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Antiviral activity of CYC202 in HIV-1-infected cells

15 August 2017

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Targeting the epidermal growth factor receptor with tyrosine kinase inhibitors: small molecules, big hopes

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Emerging concepts in targeting the polyamine metabolic pathway in epithelial cancer chemoprevention and chemotherapy

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Cdk2 knockout mice are viable

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Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling

21 January 2018

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Treatment of Vicia faba root tip cells with specific inhibitors to cyclin-dependent kinases leads to abnormal spindle formation

21 January 2018

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Inhibition of cellular Cdk2 activity blocks human cytomegalovirus replication

21 January 2018

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HIV entry inhibitors: mechanisms of action and resistance pathways

21 January 2018

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Cell cycle molecular targets in novel anticancer drug discovery

21 January 2018

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A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression

21 January 2018

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Flavopiridol inhibits P-TEFb and blocks HIV-1 replication

21 January 2018

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Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

21 January 2018

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Identification of homeodomain proteins, PBX1 and PREP1, involved in the transcription of murine leukemia virus

21 January 2018

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The poliovirus replication machinery can escape inhibition by an antiviral drug that targets a host cell protein

21 January 2018

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Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

21 January 2018

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Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol

21 January 2018

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Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

21 January 2018

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Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

21 January 2018

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New developments in anti-HIV chemotherapy

21 January 2018

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Pharmacological cyclin-dependent kinase inhibitors as HIV-1 antiviral therapeutics

21 January 2018

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Roscovitine inhibits activation of promoters in herpes simplex virus type 1 genomes independently of promoter-specific factors

21 January 2018

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Therapy for chronic obstructive pulmonary disease in the 21st century.

21 January 2018

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Cyclin-dependent kinase inhibitor indirubin-3'-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies

21 January 2018

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The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

21 January 2018

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Activation of cyclin A gene expression by the cyclin encoded by human herpesvirus-8.

21 January 2018

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A small molecule-kinase interaction map for clinical kinase inhibitors

21 January 2018

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E1A12S-mediated activation of the adenovirus type 12 E2 promoter depends on the histone acetyltransferase activity of p300/CBP.

21 January 2018

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CDK inhibitors in clinical development for the treatment of cancer

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Recent progress in the discovery and development of cyclin-dependent kinase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Antiviral activity of CTC-8 against herpes simplex virus (HSV-1) in cell culture: evidence for a selective antiviral effect via a cellular mechanism.

21 January 2018

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Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Virogenomics: a novel approach to antiviral drug discovery

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Use of a multi-virus array for the study of human viral and retroviral pathogens: gene expression studies and ChIP-chip analysis

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Reversal of collapsing glomerulopathy in mice with the cyclin-dependent kinase inhibitor CYC202.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Compartmentalization of Spermine and Spermidine in the Herpes Simplex Virion

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity

21 January 2018

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Direct activation of cyclin-dependent kinase 2 by human papillomavirus E7.

21 January 2018

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Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication

21 January 2018

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Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

21 January 2018

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Potent interaction of flavopiridol with MRP1

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

CDK11 complexes promote pre-mRNA splicing

21 January 2018

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Adenovirus-mediated transfer of p53-related genes induces apoptosis of human cancer cells

21 January 2018

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A protein-based therapeutic for human cytomegalovirus infection

21 January 2018

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The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase

21 January 2018

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Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies.

21 January 2018

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Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors.

21 January 2018

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Pharmacological inhibitors of cyclin-dependent kinases

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Imatinib-induced regression of AIDS-related Kaposi's sarcoma

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Phase II study of oral vinorelbine in first-line advanced breast cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

A fluorescence polarization assay for native protein substrates of kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Inhibition of S-phase cyclin-dependent kinase activity blocks expression of Epstein-Barr virus immediate-early and early genes, preventing viral lytic replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Viral cyclin-cyclin-dependent kinase 6 complexes initiate nuclear DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Failure to proliferate and mitotic arrest of CDK11(p110/p58)-null mutant mice at the blastocyst stage of embryonic cell development

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Therapeutic targets for HIV-1 infection in the host proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Inhibition of RANTES expression by indirubin in influenza virus-infected human bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Modulation of p27(Kip1) levels by the cyclin encoded by Kaposi's sarcoma-associated herpesvirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Polyamine Metabolism in Cells Infected with Herpes Simplex Virus

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Chemical inhibitors of cyclin-dependent kinases

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Chemical inhibitors of cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

A single amino acid substitution in the ICP27 protein of herpes simplex virus type 1 is responsible for its resistance to leptomycin B.

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Can sequencing shed light on cell cycling?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Suppression of HIV-1 viral replication and cellular pathogenesis by a novel p38/JNK kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Flavopiridol inhibits glycogen phosphorylase by binding at the inhibitor site

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Transforming growth factor alpha, Shope fibroma growth factor, and vaccinia growth factor can replace myxoma growth factor in the induction of myxomatosis in rabbits

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657, a specific p38 mitogen-activated protein kinase inhibitor: a first-in-human study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Herpes simplex type 1 induction of persistent NF-kappa B nuclear translocation increases the efficiency of virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Discovery and evaluation of dual CDK1 and CDK2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

A uniform procedure for the purification of CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Polyamine depletion of cells reduces the infectivity of herpes simplex virus but not the infectivity of Sindbis virus

21 January 2018

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https://api.crossref.org/works/10.1177%2F095632020601700601

Antiviral drugs that target cellular proteins may play major roles in combating HIV resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: induced fit as a mechanism for narrow specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Experimental genomic evolution: extensive compensation for loss of DNA ligase activity in a virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Chemical and biological profile of dual Cdk1 and Cdk2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

A novel approach to develop anti-HIV drugs: adapting non-nucleoside anticancer chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Cyclin-dependent kinase activity is required for efficient expression and posttranslational modification of human cytomegalovirus proteins and for production of extracellular particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Studies on cyclin-dependent kinase inhibitors: indolo-[2,3- a ]pyrrolo[3,4- c ]carbazoles versus bis-indolylmaleimides

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Cyclins and CDKS in development and cancer: lessons from genetically modified mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Cyclin-dependent kinases as cellular targets for antiviral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Discovery of the antiviral activities of pharmacologic cyclin-dependent kinase inhibitors: from basic to applied science.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Herpes simplex viruses in antiviral drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Roscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Preclinical and clinical development of cyclin-dependent kinase modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Viral and host-cell protein kinases: enticing antiviral targets and relevance of nucleoside, and viral thymidine, kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Inhibition of cyclin-dependent kinase 4 (Cdk4) by fascaplysin, a marine natural product

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Cells lacking NF-kappaB or in which NF-kappaB is not activated vary with respect to ability to sustain herpes simplex virus 1 replication and are not susceptible to apoptosis induced by a replication-incompetent mutant virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Human cytomegalovirus infection induces specific hyperphosphorylation of the carboxyl-terminal domain of the large subunit of RNA polymerase II that is associated with changes in the abundance, activity, and localization of cdk9 and cdk7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Roscovitine, a cyclin-dependent kinase inhibitor, prevents replication of varicella-zoster virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Cyclin-dependent kinase inhibitors for treating cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Polyamine metabolism in MRC5 cells infected with different herpesviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

The Sequence of the Human Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Inhibition of cyclin-dependent kinases by purine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Inhibition of HTLV-1 transcription by cyclin dependent kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Indirubin-3'-oxime inhibits c-Jun NH2-terminal kinase: anti-apoptotic effect in cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Adenovirus-mediated p14(ARF) gene transfer in human mesothelioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Bioluminescent imaging of Cdk2 inhibition in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

Using a mammalian cell cycle simulation to interpret differential kinase inhibition in anti-tumour pharmaceutical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F095632020601700601

10.1177/095632020601700601

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference