Inhibitors of NF-kappaB signaling: 785 and counting (Q36637918)

15 August 2017

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title

Inhibitors of NF-kappaB signaling: 785 and counting (English)

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15 August 2017

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Gilmore TD

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15 August 2017

Herscovitch M

series ordinal

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15 August 2017

language of work or name

English

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publication date

1 October 2006

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15 August 2017

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

6887-6899

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Oral administration of the anti-inflammatory substance triflusal results in the downregulation of constitutive transcription factor NF-kappaB in the postnatal rat brain

15 August 2017

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BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice

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The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression

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Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase

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Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway.

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Mutations in the NF-kappaB signaling pathway: implications for human disease

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7 January 2021

Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation.

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7 January 2021

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

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7 January 2021

Current insights into the regulation of programmed cell death by NF-kappaB.

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7 January 2021

Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity

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7 January 2021

IL-10 down-regulates human microglial IL-8 by inhibition of NF-kappaB activation

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7 January 2021

Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway

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7 January 2021

Lactacystin, proteasome function, and cell fate

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7 January 2021

Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.

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7 January 2021

A p105-based inhibitor broadly represses NF-kappa B activities

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7 January 2021

Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones

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7 January 2021

Role of cysteine residues of p65/NF-kappaB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential

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7 January 2021

Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

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7 January 2021

Introduction to NF-kappaB: players, pathways, perspectives

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7 January 2021

Neuroprotection by aspirin and sodium salicylate through blockade of NF-kappaB activation.

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7 January 2021

Bcl-2 down-regulates the activity of transcription factor NF-kappaB induced upon apoptosis

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7 January 2021

Inhibition of NF-kappa B activation in vitro and in vivo: role of 26S proteasome

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7 January 2021

Evidence that reactive oxygen species do not mediate NF-kappaB activation

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7 January 2021

NF-kappaB and the immune response

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7 January 2021

NF-kappa B as a therapeutic target in multiple myeloma

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7 January 2021

Inhibition of TNF-alpha-induced RANTES expression in human hepatocyte-derived cells by fibrates, the hypolipidemic drugs

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7 January 2021

MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha.

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7 January 2021

Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses

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7 January 2021

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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7 January 2021

HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo

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7 January 2021

Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha

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7 January 2021

B-oligomer of pertussis toxin inhibits HIV-1 LTR-driven transcription through suppression of NF-kappaB p65 subunit activity

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7 January 2021

Potent Inhibitors of Proteasome

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7 January 2021

Regulation of NF-kappaB signaling by decoy oligodeoxynucleotides

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7 January 2021

Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors

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7 January 2021

Antitumoural effects of the pyridyl cyanoguanidine CHS 828 on three different types of neuroendocrine tumours xenografted to nude mice

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7 January 2021

Transcription factor cross-talk: the estrogen receptor and NF-kappaB.

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7 January 2021

Role of Rel/NF-kappaB transcription factors during the outgrowth of the vertebrate limb.

1 reference

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7 January 2021

Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase

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7 January 2021

JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?

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7 January 2021

The IKK NF-kappa B system: a treasure trove for drug development

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7 January 2021

Use of phosphorothioate-modified oligodeoxynucleotides to inhibit NF-kappaB expression and lymphocyte function

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Inhibition of NF-kappa B by sodium salicylate and aspirin

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Interleukin 1 beta-induced expression of nitric oxide synthase in rat renal mesangial cells is suppressed by cyclosporin A

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7 January 2021

Retroinfusion of NFkappaB decoy oligonucleotide extends cardioprotection achieved by CD18 inhibition in a preclinical study of myocardial ischemia and retroinfusion in pigs

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7 January 2021

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase

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7 January 2021

FK506 inhibits tumour necrosis factor-alpha secretion in human keratinocytes via regulation of nuclear factor-kappaB.

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7 January 2021

Rapamycin suppresses experimental aortic aneurysm growth

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7 January 2021

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

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7 January 2021

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

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7 January 2021

In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13.

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7 January 2021

An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4

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7 January 2021

C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases

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7 January 2021

Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms

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7 January 2021

ACEI attenuates the progression of CCl4-induced rat hepatic fibrogenesis by inhibiting TGF-beta1, PDGF-BB, NF-kappaB and MMP-2,9

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7 January 2021

Jesterone dimer, a synthetic derivative of the fungal metabolite jesterone, blocks activation of transcription factor nuclear factor kappaB by inhibiting the inhibitor of kappaB kinase.

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7 January 2021

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

1 reference

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7 January 2021

Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence

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7 January 2021

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176

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7 January 2021

Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant

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7 January 2021

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7 January 2021

Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1

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7 January 2021

Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1

1 reference

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7 January 2021

Cyclosporin A interferes with the inducible degradation of NF‐xB inhibitors, but not with the processing of p105/NF‐xB1 in T cells

1 reference

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7 January 2021

Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway.

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7 January 2021

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

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7 January 2021

Cyclosporin A sensitivity of the NF-kappa B site of the IL2R alpha promoter in untransformed murine T cells

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7 January 2021

Preadministration of High-Dose Salicylates, Suppressors of NF- B Activation, May Increase the Chemosensitivity of Many Cancers: An Example of Proapoptotic Signal Modulation Therapy

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7 January 2021

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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7 January 2021

Cyclosporine A is an uncompetitive inhibitor of proteasome activity and prevents NF-kappaB activation

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7 January 2021

Effects of clarithromycin on cultured human nasal epithelial cells and fibroblasts

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7 January 2021

In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction

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7 January 2021

Intracellular signaling network as a prime chemopreventive target of (-)-epigallocatechin gallate

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7 January 2021

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B

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7 January 2021

Proteasome inhibitors induce inhibitory kappa B (I kappa B) kinase activation, I kappa B alpha degradation, and nuclear factor kappa B activation in HT-29 cells

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7 January 2021

Proteolytic Cleavage of the p65-RelA Subunit of NF-κB during Poliovirus Infection

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7 January 2021

The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formation

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7 January 2021

Cyclosporin A inhibits the early phase of NF-kappaB/RelA activation induced by CD28 costimulatory signaling to reduce the IL-2 expression in human peripheral T cells

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7 January 2021

Targeted CML therapy: controlling drug resistance, seeking cure

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7 January 2021

Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells

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7 January 2021

Raloxifene-induced myeloma cell apoptosis: a study of nuclear factor-kappaB inhibition and gene expression signature

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7 January 2021

Activators and target genes of Rel/NF-kappaB transcription factors

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7 January 2021

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

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7 January 2021

NF-kappaB in human disease: current inhibitors and prospects for de novo structure based design of inhibitors

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7 January 2021

Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

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7 January 2021

Dual angiotensin-converting enzyme/neutral endopeptidase inhibition on cardiac and renal fibrosis and inflammation in DOCA-salt hypertensive rats

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7 January 2021

Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Identification and characterization of an IkappaB kinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

I-kappa B kinases alpha and beta have distinct roles in regulating murine T cell function

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Inhibition of nuclear factor kappaB activation by a virus-encoded IkappaB-like protein

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Activation of the heat shock factor 1 by serine protease inhibitors. An effect associated with nuclear factor-kappaB inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Troglitazone Antagonizes Tumor Necrosis Factor-α-induced Reprogramming of Adipocyte Gene Expression by Inhibiting the Transcriptional Regulatory Functions of NF-κB

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7 January 2021

IkappaB kinase complexes: gateways to NF-kappaB activation and transcription

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

The yopJ locus is required for Yersinia-mediated inhibition of NF-kappaB activation and cytokine expression: YopJ contains a eukaryotic SH2-like domain that is essential for its repressive activity

1 reference

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7 January 2021

Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review)

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7 January 2021

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Involvement of intracellular Ca2+ in oxidant-induced NF-kappa B activation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

The architecture of the interleukin-2 promoter: a reflection of T lymphocyte activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Inhibition of interleukin-12 expression in diltiazem-treated dendritic cells through the reduction of nuclear factor-kappa B transcriptional activity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

An allosteric drug, o,o'-bismyristoyl thiamine disulfide, suppresses HIV-1 replication through prevention of nuclear translocation of both HIV-1 Tat and NF-kappa B.

1 reference

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7 January 2021

Inhibition of NF-kappa B binding to DNA by chromium, cadmium, mercury, zinc, and arsenite in vitro: evidence of a thiol mechanism

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7 January 2021

Protein-tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-kappa B.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

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7 January 2021

Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

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7 January 2021

A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats

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7 January 2021

Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation

1 reference

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7 January 2021

Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells

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7 January 2021

Inhibitor kappaB-like proteins from a polydnavirus inhibit NF-kappaB activation and suppress the insect immune response

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7 January 2021

Transcription Factors as Molecular Targets: Molecular Mechanisms of Decoy ODN and their Design

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7 January 2021

Interleukin-11. A gp130 cytokine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Inhibition of the endothelial cell activation by antithrombin in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

FK506 inhibits antigen receptor-mediated induction of c-rel in B and T lymphoid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Anti-inflammatory effects of moxifloxacin on activated human monocytic cells: inhibition of NF-kappaB and mitogen-activated protein kinase activation and of synthesis of proinflammatory cytokines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

The actions of NSAIDs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

The kinase inhibitor imatinib mesylate inhibits TNF-{alpha} production in vitro and prevents TNF-dependent acute hepatic inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Inhibition of the DNA-binding activity of NF-kappa B by gold compounds in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209982

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209982

1 reference

release_2hlri25ckbgavcn43jjkdkflum

15 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/2hlri25ckbgavcn43jjkdkflum

24 November 2022

mapped directly with Wikidata item

1 reference