Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs (Q36622844)

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scientific article published on 9 December 2014

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English	Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs	scientific article published on 9 December 2014

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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James Leiper

13

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Paul C J Armstrong

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Paul C J Armstrong

9

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Timothy D Warner

object named as

Timothy D Warner

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author name string

Blerina Ahmetaj-Shala

1

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Europe PubMed Central

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15 August 2017

Nicholas S Kirkby

2

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Europe PubMed Central

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15 August 2017

Rebecca Knowles

3

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Europe PubMed Central

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15 August 2017

Malak Al'Yamani

4

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Europe PubMed Central

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15 August 2017

Sarah Mazi

5

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Europe PubMed Central

PMC publication ID

15 August 2017

Zhen Wang

6

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Arthur T Tucker

7

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Europe PubMed Central

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15 August 2017

Louise Mackenzie

8

1 reference

Europe PubMed Central

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15 August 2017

Rolf M Nüsing

10

1 reference

Europe PubMed Central

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15 August 2017

James A P Tomlinson

11

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15 August 2017

Jane A Mitchell

14

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15 August 2017

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publication date

9 December 2014

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Europe PubMed Central

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15 August 2017

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Europe PubMed Central

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15 August 2017

131

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Europe PubMed Central

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15 August 2017

7

1 reference

Europe PubMed Central

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15 August 2017

633-642

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Cardiovascular events associated with the long-term use of NSAIDs: a review of randomized controlled trials and observational studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Physiologic and pathophysiologic roles of cyclooxygenase-2 in the kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Vascular COX-2 modulates blood pressure and thrombosis in mice.

1 reference

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30 September 2017

Endogenous nitric oxide synthase inhibitors in the biology of disease: markers, mediators, and regulators?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

The effects of nonsteroidal anti-inflammatory drugs on blood pressure in hypertensive patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Human alanine-glyoxylate aminotransferase 2 lowers asymmetric dimethylarginine and protects from inhibition of nitric oxide production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Prostaglandins, NSAIDs, and Gastric Mucosal Protection: Why Doesn't the Stomach Digest Itself?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Cyclooxygenase in normal human tissues--is COX-1 really a constitutive isoform, and COX-2 an inducible isoform?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

COX-2 inhibitors and cardiovascular risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Disruption of methylarginine metabolism impairs vascular homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Celecoxib for the prevention of sporadic colorectal adenomas

1 reference

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30 September 2017

Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial

1 reference

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30 September 2017

Plasma concentration of asymmetric dimethylarginine and the risk of coronary heart disease: rationale and design of the multicenter CARDIAC study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Renal effects of cyclooxygyenase-2-selective inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Pharmacology of cyclooxygenase-2 inhibition in the kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Cyclooxygenase-2 inhibition and renal physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

COX-2 and the kidneys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group

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30 September 2017

Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis

1 reference

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30 September 2017

Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension

1 reference

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30 September 2017

The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase

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30 September 2017

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Role of endothelium-derived nitric oxide in the regulation of blood pressure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

30 September 2017

Localization of cyclooxygenase-1 and -2 in adult and fetal human kidney: implication for renal function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

28 June 2018

Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

20 September 2018

NSAID use and association with cardiovascular outcomes in outpatients with stable atherothrombotic disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4768634

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Consequences of increased systolic blood pressure in patients with osteoarthritis and rheumatoid arthritis

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20 September 2018

Effects of COX-2 inhibitors on aortic prostacyclin production in cholesterol-fed rabbits

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20 September 2018

Mild-to-moderate hypertriglyceridemia in young men is associated with endothelial dysfunction and increased plasma concentrations of asymmetric dimethylarginine

1 reference

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20 September 2018

Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension

1 reference

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20 September 2018

Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis

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Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans

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https://pubmed.ncbi.nlm.nih.gov/25492024

12 December 2020

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Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/25492024

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Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function

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https://pubmed.ncbi.nlm.nih.gov/25492024

12 December 2020

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inferred from PubMed ID database lookup

Involvement of cyclo-oxygenase-1-mediated prostacyclin synthesis in the vasoconstrictor activity evoked by ACh in mouse arteries

1 reference

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12 December 2020

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NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/25492024

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L-glutamine inhibits the release of endothelium-derived relaxing factor from the rabbit aorta

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10.1161/CIRCULATIONAHA.114.011591

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Europe PubMed Central

PMC publication ID

15 August 2017

release_2dmknzcufvecxja6shidei32di

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https://api.fatcat.wiki/v0/release/2dmknzcufvecxja6shidei32di

24 November 2022

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mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

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15 August 2017

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