Competence and competition: the challenge of becoming a long-lived plasma cell (Q36594883)

15 August 2017

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title

Competence and competition: the challenge of becoming a long-lived plasma cell (English)

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15 August 2017

Falk Hiepe

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Andreas Radbruch

object named as

Andreas Radbruch

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15 August 2017

author name string

Gwendolin Muehlinghaus

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15 August 2017

Elke O Luger

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15 August 2017

Ayako Inamine

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15 August 2017

Kenneth G C Smith

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15 August 2017

Thomas Dörner

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15 August 2017

Falk Hiepe

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15 August 2017

language of work or name

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15 September 2006

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Nature Reviews Immunology

15 August 2017

published in

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

741-750

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Immunological memory and protective immunity: understanding their relation

15 August 2017

cites work

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SINGLE CELL STUDIES ON 19S ANTIBODY PRODUCTION

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Survival of long-lived plasma cells is independent of antigen.

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Blimp-1 is required for maintenance of long-lived plasma cells in the bone marrow

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Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells

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The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response

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XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

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Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

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Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRI1886

1 reference

15 August 2017

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