NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration (Q36530569)

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scientific article published on 7 January 2013

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English	NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration	scientific article published on 7 January 2013

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19 February 2020

NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration (English)

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19 February 2020

inflammasome complex

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macular degeneration

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Kameran Lashkari

4

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19 February 2020

Patricia D'Amore

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19 February 2020

Bruce R Ksander

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Bruce R Ksander

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19 February 2020

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Wen Allen Tseng

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19 February 2020

Thuzar Thein

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19 February 2020

Kati Kinnunen

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19 February 2020

Meredith S Gregory

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19 February 2020

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7 January 2013

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19 February 2020

Investigative Ophthalmology Visual Science

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19 February 2020

54

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19 February 2020

1

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19 February 2020

110-120

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19 February 2020

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544415

30 September 2017

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

1 reference

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30 September 2017

Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration.

1 reference

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30 September 2017

Expression and role of VEGF in the adult retinal pigment epithelium

1 reference

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30 September 2017

Age related macular degeneration and drusen: neuroinflammation in the retina

1 reference

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Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk

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Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway

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30 September 2017

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

1 reference

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30 September 2017

Inflammasomes: current understanding and open questions

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30 September 2017

Central roles of NLRs and inflammasomes in viral infection

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30 September 2017

Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation

1 reference

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30 September 2017

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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30 September 2017

Relative contribution of VEGF and TNF-alpha in the cynomolgus laser-induced CNV model: comparing the efficacy of bevacizumab, adalimumab, and ESBA105.

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30 September 2017

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration

1 reference

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Differential role of tumor necrosis factor (TNF)-alpha receptors in the development of choroidal neovascularization

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30 September 2017

The inflammasomes

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30 September 2017

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

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30 September 2017

Critical functions of priming and lysosomal damage for NLRP3 activation

1 reference

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30 September 2017

Inflammasomes: too big to miss

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544415

30 September 2017

Soluble and mature amyloid fibrils in drusen deposits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544415

30 September 2017

Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544415

30 September 2017

Para-inflammation in the aging retina.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544415

30 September 2017

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

1 reference

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30 September 2017

Pyroptosis: host cell death and inflammation

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30 September 2017

Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544415

30 September 2017

Origin and physiological roles of inflammation

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30 September 2017

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544415

30 September 2017

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

1 reference

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30 September 2017

Oxidative damage-induced inflammation initiates age-related macular degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544415

30 September 2017

Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe.

1 reference

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30 September 2017

Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages

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30 September 2017

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

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30 September 2017

Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

1 reference

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Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration

1 reference

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The role of inflammation in the pathogenesis of age-related macular degeneration

1 reference

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30 September 2017

Drusen complement components C3a and C5a promote choroidal neovascularization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3544415

30 September 2017

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

1 reference

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RPE lipofuscin and its role in retinal pathobiology

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Global data on visual impairment in the year 2002

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Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments.

1 reference

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Current concepts in the pathogenesis of age-related macular degeneration

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1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23221073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1167/IOVS.12-10655

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Europe PubMed Central

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19 February 2020

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Europe PubMed Central

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19 February 2020

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Europe PubMed Central

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19 February 2020

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