Filarial nematode secreted product ES-62 is an anti-inflammatory agent: therapeutic potential of small molecule derivatives and ES-62 peptide mimetics (Q36478837)

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English	Filarial nematode secreted product ES-62 is an anti-inflammatory agent: therapeutic potential of small molecule derivatives and ES-62 peptide mimetics	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

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Europe PubMed Central

Filarial nematode secreted product ES-62 is an anti-inflammatory agent: therapeutic potential of small molecule derivatives and ES-62 peptide mimetics (English)

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

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author name string

William Harnett

1

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

Margaret M Harnett

2

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

publication date

1 May 2006

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Europe PubMed Central

PubMed publication ID

14 August 2017

Clinical and Experimental Pharmacology and Physiology

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Europe PubMed Central

PubMed publication ID

14 August 2017

33

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Europe PubMed Central

PubMed publication ID

14 August 2017

5-6

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

511-518

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections.

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A worm's eye view of the immune system: consequences for evolution of human autoimmune disease.

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Infections and allergy - helminths, hygiene and host immune regulation

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The dynamics of Wuchereria bancrofti infection: a model-based analysis of longitudinal data from Pondicherry, India

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Transmission intensity and human immune responses to lymphatic filariasis

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Pathogenesis and host responses in human onchocerciasis: impact of Onchocerca filariae and Wolbachia endobacteria

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Expression of the filarial nematode phosphorylcholine-containing glycoprotein, ES62, is stage specific.

1 reference

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Stage-specific and species-specific differences in the production of the mRNA and protein for the filarial nematode secreted product, ES-62.

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Induction of signalling anergy via the T-cell receptor in cultured Jurkat T cells by pre-exposure to a filarial nematode secreted product

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In vivo activation of murine peritoneal B1 cells by the filarial nematode phosphorylcholine-containing glycoprotein ES-62.

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Presence of phosphorylcholine on a filarial nematode protein influences immunoglobulin G subclass response to the molecule by an interleukin-10-dependent mechanism

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ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo.

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Immunotherapy for rheumatoid arthritis

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Role of cytokines in rheumatoid arthritis

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A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62.

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The anti-inflammatory potential of the filarial nematode secreted product, ES-62.

1 reference

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ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential

1 reference

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Subversion of immunological signalling by a filarial nematode phosphorylcholine-containing secreted product

1 reference

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Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62.

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B cell antigen receptor signaling: roles in cell development and disease.

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Differential signalling during B-cell maturation

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Differential regulation of mRNAs encoding protein kinase C isoenzymes in activated human B cells

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A filarial nematode-secreted phosphorylcholine-containing glycoprotein uncouples the B cell antigen receptor from extracellular signal-regulated kinase-mitogen-activated protein kinase by promoting the surface Ig-mediated recruitment of Src homology

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Differential regulation of interleukin-12 p40 and p35 induction via Erk mitogen-activated protein kinase-dependent and -independent mechanisms and the implications for bioactive IL-12 and IL-23 responses

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In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype

1 reference

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Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62.

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Proinflammatory cytokines dominate the early immune response to filarial parasites

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Toll-like receptors

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Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

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Toll-like receptor signalling

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

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Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

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Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

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Structural/functional aspects of ES-62--a secreted immunomodulatory phosphorylcholine-containing filarial nematode glycoprotein

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Molecular cloning and demonstration of an aminopeptidase activity in a filarial nematode glycoprotein

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Specific phospholipid oxidation products inhibit ligand activation of toll-like receptors 4 and 2.

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Receptors involved in the oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine-mediated synthesis of interleukin-8. A role for Toll-like receptor 4 and a glycosylphosphatidylinositol-anchored protein

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Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonema viteae

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Identifiers

10.1111/J.1440-1681.2006.04400.X

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

14 August 2017

ResearchGate publication ID

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