Design and development of polymers for gene delivery (Q36211579)

12 August 2017

1 reference

title

Design and development of polymers for gene delivery (English)

1 reference

12 August 2017

Daniel W Pack

1 reference

12 August 2017

Allan S Hoffman

series ordinal

1 reference

12 August 2017

Suzie Pun

series ordinal

1 reference

12 August 2017

Patrick S Stayton

series ordinal

1 reference

12 August 2017

publication date

1 July 2005

1 reference

Nature Reviews Drug Discovery

12 August 2017

published in

1 reference

12 August 2017

1 reference

12 August 2017

1 reference

12 August 2017

page(s)

581-593

1 reference

The basic science of gene therapy

12 August 2017

cites work

1 reference

Gene therapy progress and prospects: gene therapy for the hemophilias

31 March 2020

1 reference

Advances in Duchenne muscular dystrophy gene therapy

31 March 2020

1 reference

Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis.

31 March 2020

1 reference

Current perceptions of cardiovascular gene therapy.

31 March 2020

1 reference

Gene therapy progress and prospects: Parkinson's disease

31 March 2020

1 reference

Gene therapy for amyotrophic lateral sclerosis and other motor neuron diseases

31 March 2020

1 reference

Growth-factor gene therapy for neurodegenerative disorders

31 March 2020

1 reference

Gene therapy for infectious diseases

31 March 2020

1 reference

Gene therapy for tissue regeneration

31 March 2020

1 reference

Cancer gene therapy: hard lessons and new courses

31 March 2020

1 reference

Clinical development of gene therapy for colorectal cancer

31 March 2020

1 reference

Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes.

31 March 2020

1 reference

Gene therapy for cardiovascular diseases

31 March 2020

1 reference

31 March 2020

DNA vaccines: a review

1 reference

T lymphocyte-directed gene therapy for ADA- SCID: initial trial results after 4 years.

31 March 2020

1 reference

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

31 March 2020

1 reference

Evidence for gene transfer and expression of factor IX in haemophilia B patients treated with an AAV vector.

31 March 2020

1 reference

a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

31 March 2020

1 reference

Gene therapy -- promises, problems and prospects

31 March 2020

1 reference

Adeno-associated virus as a gene delivery system

31 March 2020

1 reference

Retroviral vectors. From laboratory tools to molecular medicine

31 March 2020

1 reference

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure

31 March 2020

1 reference

An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery

31 March 2020

1 reference

Cationic lipids used in gene transfer

31 March 2020

1 reference

Direct real-time molecular scale visualisation of the degradation of condensed DNA complexes exposed to DNase I

31 March 2020

1 reference

DNA condensation by multivalent cations

31 March 2020

1 reference

Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells

31 March 2020

1 reference

DNA condensation for gene therapy as monitored by atomic force microscopy

31 March 2020

1 reference

Monitoring DNA/poly-L-lysine polyplex formation with time-resolved multiangle laser light scattering

31 March 2020

1 reference

DNA interpolyelectrolyte complexes as a tool for efficient cell transformation

31 March 2020

1 reference

Peptide-mediated gene delivery: influence of peptide structure on gene expression

31 March 2020

1 reference

Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes

31 March 2020

1 reference

Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery

31 March 2020

1 reference

Polyelectrolyte vectors for gene delivery: influence of cationic polymer on biophysical properties of complexes formed with DNA.

31 March 2020

1 reference

Mechanism of oligonucleotide release from cationic liposomes

31 March 2020

1 reference

Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery

31 March 2020

1 reference

PEGylated DNA/transferrin-PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery

31 March 2020

1 reference

Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers.

31 March 2020

1 reference

Steric Stabilization of poly-l-Lysine/DNA Complexes by the Covalent Attachment of Semitelechelic poly[N-(2-Hydroxypropyl)methacrylamide]

31 March 2020

1 reference

Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin

31 March 2020

1 reference

Influence of hydrophilicity of cationic polymers on the biophysical properties of polyelectrolyte complexes formed by self-assembly with DNA.

31 March 2020

1 reference

The Level of Hydrophobic Substitution and the Molecular Weight of Amphiphilic Poly-L-lysine-Based Polymers Strongly Affects Their Assembly into Polymeric Bilayer Vesicles

31 March 2020

1 reference

Gene transfer by DNA/glycosylated polylysine complexes into human blood monocyte-derived macrophages

31 March 2020

1 reference

Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

31 March 2020

1 reference

PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles

31 March 2020

1 reference

Glycosylated Polylysine/DNA Complexes: Gene Transfer Efficiency in Relation with the Size and the Sugar Substitution Level of Glycosylated Polylysines and with the Plasmid Size

31 March 2020

1 reference

Receptor-mediated gene transfer into macrophages

31 March 2020

1 reference

In vitro gene delivery to hepatocytes with galactosylated polyethylenimine

31 March 2020

1 reference

Size reduction of galactosylated PEI/DNA complexes improves lectin-mediated gene transfer into hepatocytes

31 March 2020

1 reference

Folate copolymer-mediated transfection of cultured cells

31 March 2020

1 reference

Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels

31 March 2020

1 reference

Transferrin-polycation conjugates as carriers for DNA uptake into cells

31 March 2020

1 reference

Receptor-mediated endocytosis of transferrin-polycation conjugates: an efficient way to introduce DNA into hematopoietic cells

31 March 2020

1 reference

Transferrinfection: a highly efficient way to express gene constructs in eukaryotic cells

31 March 2020

1 reference

Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery

31 March 2020

1 reference

An RGD-oligolysine peptide: a prototype construct for integrin-mediated gene delivery

31 March 2020

1 reference

Optimization of cell surface binding enhances efficiency and specificity of molecular conjugate gene delivery

31 March 2020

1 reference

Transfection by cationic liposomes using simultaneous single cell measurements of plasmid delivery and transgene expression

31 March 2020

1 reference

31 March 2020

1 reference

Evidence for the role of proteoglycans in cation-mediated gene transfer

31 March 2020

1 reference

Putative role of chloroquine in gene transfer into a human hepatoma cell line by DNA/lactosylated polylysine complexes

31 March 2020

1 reference

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery

31 March 2020

1 reference

Hepatic gene therapy: adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes

31 March 2020

1 reference

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes

31 March 2020

1 reference

High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles.

31 March 2020

1 reference

Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle

31 March 2020

1 reference

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand.

31 March 2020

1 reference

Specific gene transfer mediated by lactosylated poly-L-lysine into hepatoma cells

31 March 2020

1 reference

Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers.

31 March 2020

1 reference

A new gene delivery formulation of polyethylenimine/DNA complexes coated with PEG conjugated fusogenic peptide

31 March 2020

1 reference

Improved transfection using epithelial cell line-selected ligands and fusogenic peptides

31 March 2020

1 reference

Hindered diffusion of inert tracer particles in the cytoplasm of mouse 3T3 cells

31 March 2020

1 reference

Size-dependent DNA mobility in cytoplasm and nucleus

31 March 2020

1 reference

Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer

31 March 2020

1 reference

Efficient active transport of gene nanocarriers to the cell nucleus

31 March 2020

1 reference

Nuclear targeting peptide scaffolds for lipofection of nondividing mammalian cells

31 March 2020

1 reference

Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus

31 March 2020

1 reference

Enhancement of polylysine-mediated transferrinfection by nuclear localization sequences: polylysine does not function as a nuclear localization sequence

31 March 2020

1 reference

Supramolecular structure and nuclear targeting efficiency determine the enhancement of transfection by modified polylysines.

31 March 2020

1 reference

DNA vector chemistry: the covalent attachment of signal peptides to plasmid DNA

31 March 2020

1 reference

A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA.

31 March 2020

1 reference

Coupling of nuclear localization signals to plasmid DNA and specific interaction of the conjugates with importin alpha.

31 March 2020

1 reference

Factors influencing the ability of nuclear localization sequence peptides to enhance nonviral gene delivery

31 March 2020

1 reference

The reduction of the positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes

31 March 2020

1 reference

Polylysine-based transfection systems utilizing receptor-mediated delivery

31 March 2020

1 reference

Receptor-mediated transport of DNA into eukaryotic cells

31 March 2020

1 reference

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake

31 March 2020

1 reference

Targeted Gene Delivery with a Low Molecular Weight Glycopeptide Carrier

31 March 2020

1 reference

Anti-JL1 antibody-conjugated poly (L-lysine) for targeted gene delivery to leukemia T cells

31 March 2020

1 reference

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

31 March 2020

1 reference

Mannose polyethylenimine conjugates for targeted DNA delivery into dendritic cells

31 March 2020

1 reference

Tumor targeting with surface-shielded ligand--polycation DNA complexes.

31 March 2020

1 reference

Targeted transfer of polyethylenimine-avidin-DNA bioconjugates to hematopoietic cells using biotinylated monoclonal antibodies

31 March 2020

1 reference

A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine

31 March 2020

1 reference

Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system

31 March 2020

1 reference

Nonviral Gene Delivery to the Rat Kidney with Polyethylenimine

31 March 2020

1 reference

Polyethylenimine-based intravenous delivery of transgenes to mouse lung.

31 March 2020

1 reference

Polyethylenimine shows properties of interest for cystic fibrosis gene therapy

31 March 2020

1 reference

In vivo delivery to tumors of DNA complexed with linear polyethylenimine.

31 March 2020

1 reference

Partial acetylation of polyethylenimine enhances in vitro gene delivery.

31 March 2020

1 reference

Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells

31 March 2020

1 reference

Starburst Dendrimers: Molecular-Level Control of Size, Shape, Surface Chemistry, Topology, and Flexibility from Atoms to Macroscopic Matter

31 March 2020

1 reference

Polyamidoamine cascade polymers mediate efficient transfection of cells in culture

31 March 2020

1 reference

Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV)-based plasmid vector carrying the CEA promoter

31 March 2020

1 reference

In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers

31 March 2020

1 reference

Highly efficient suicide gene expression in hepatocellular carcinoma cells by epstein-barr virus-based plasmid vectors combined with polyamidoamine dendrimer

31 March 2020

1 reference

Effective suicide gene therapy in vivo by EBV-based plasmid vector coupled with polyamidoamine dendrimer

31 March 2020

1 reference

In vitro gene delivery by degraded polyamidoamine dendrimers

31 March 2020

1 reference

The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes

31 March 2020

1 reference

Histidine containing peptides and polypeptides as nucleic acid vectors.

31 March 2020

1 reference

High transfection efficiency of poly(4-vinylimidazole) as a new gene carrier

31 March 2020

1 reference

Efficient gene transfer by histidylated polylysine/pDNA complexes

31 March 2020

1 reference

Histidylated oligolysines increase the transmembrane passage and the biological activity of antisense oligonucleotides

31 March 2020

1 reference

From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy

31 March 2020

1 reference

Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin

31 March 2020

1 reference

Membrane Translocation of Charged Residues at the Tips of Hydrophobic Helices in the T Domain of Diphtheria Toxin†

31 March 2020

1 reference

Influence of endosome-destabilizing peptides on efficacy of anti-HIV immunotoxins

31 March 2020

1 reference

pH-dependent bilayer destabilization by an amphipathic peptide

31 March 2020

1 reference

Membrane solubilization by a hydrophobic polyelectrolyte: surface activity and membrane binding

31 March 2020

1 reference

The design and synthesis of polymers for eukaryotic membrane disruption.

31 March 2020

1 reference

A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer

31 March 2020

1 reference

pH-sensitive polymers that enhance intracellular drug delivery in vivo

31 March 2020

1 reference

Formulation of chitosan-DNA nanoparticles with poly(propyl acrylic acid) enhances gene expression.

31 March 2020

1 reference

Poly(propylacrylic acid)-mediated serum stabilization of cationic lipoplexes

31 March 2020

1 reference

Gene and other biological therapies for vascular diseases

31 March 2020

1 reference

A new pH-responsive and glutathione-reactive, endosomal membrane-disruptive polymeric carrier for intracellular delivery of biomolecular drugs

31 March 2020

1 reference

Bioinspired pH-responsive polymers for the intracellular delivery of biomolecular drugs.

31 March 2020

1 reference

Design and synthesis of pH-responsive polymeric carriers that target uptake and enhance the intracellular delivery of oligonucleotides

31 March 2020

1 reference

New class of polymers for the delivery of macromolecular therapeutics

31 March 2020

1 reference

Effects of structure of beta-cyclodextrin-containing polymers on gene delivery

31 March 2020

1 reference

Structural effects of carbohydrate-containing polycations on gene delivery. 1. Carbohydrate size and its distance from charge centers

31 March 2020

1 reference

Structural effects of carbohydrate-containing polycations on gene delivery. 2. Charge center type

31 March 2020

1 reference

Structural effects of carbohydrate-containing polycations on gene delivery. 3. Cyclodextrin type and functionalization

31 March 2020

1 reference

Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers

31 March 2020

1 reference

Cyclodextrin-based pharmaceutics: past, present and future

31 March 2020

1 reference

Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with alpha-cyclodextrin

31 March 2020

1 reference

In vitro and in vivo gene transfer by an optimized alpha-cyclodextrin conjugate with polyamidoamine dendrimer

31 March 2020

1 reference

Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta-, and gamma-cyclodextrins

31 March 2020

1 reference

Cyclodextrin-polyethylenimine conjugates for targeted in vitro gene delivery.

31 March 2020

1 reference

Cyclodextrin-modified polyethylenimine polymers for gene delivery

31 March 2020

1 reference

Development of a nonviral gene delivery vehicle for systemic application

31 March 2020

1 reference

Transferrin-Containing, Cyclodextrin Polymer-Based Particles for Tumor-Targeted Gene Delivery

31 March 2020

1 reference

Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles

31 March 2020

1 reference

Cationic hyperbranched poly(amino ester): a novel class of DNA condensing molecule with cationic surface, biodegradable three-dimensional structure, and tertiary amine groups in the interior

31 March 2020

1 reference

Degradable polymeric carrier for the delivery of IL-10 plasmid DNA to prevent autoimmune insulitis of NOD mice

31 March 2020

1 reference

Degradable Poly(β-amino esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA

31 March 2020

1 reference

pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH Financial support was provided by the NSF (Cooperative Agreement No. ECC9843342 to the MIT Biotechnology Process Engineering Center), the

31 March 2020

1 reference

Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library.

31 March 2020

1 reference

Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines

31 March 2020

1 reference

A polymer library approach to suicide gene therapy for cancer

31 March 2020

1 reference

A degradable polyethylenimine derivative with low toxicity for highly efficient gene delivery.

31 March 2020

1 reference

Poly[Lys-(AEDTP)]: a cationic polymer that allows dissociation of pDNA/cationic polymer complexes in a reductive medium and enhances polyfection

31 March 2020

1 reference

Efficient gene transfer using reversibly cross-linked low molecular weight polyethylenimine

31 March 2020

1 reference

Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes

31 March 2020

1 reference

The Proton Sponge: a Trick to Enter Cells the Viruses Did Not Exploit

31 March 2020

1 reference

COCI

https://opencitations.net/index/coci/api/v1/citations/10.2533/CHIMIA.1997.34

8 July 2023

Identifiers

DOI

10.1038/NRD1775

1 reference

12 August 2017

1 reference