Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration (Q36188775)

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English	Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

12 August 2017

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Alzheimer's disease

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author name string

K Saito

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

J S Elce

2

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Europe PubMed Central

PMC publication ID

12 August 2017

J E Hamos

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

R A Nixon

4

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Europe PubMed Central

PMC publication ID

12 August 2017

language of work or name

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publication date

1 April 1993

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Europe PubMed Central

PMC publication ID

12 August 2017

number of pages

5

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inferred from page(s)

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PMC publication ID

12 August 2017

90

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

7

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

2628-2632

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Europe PubMed Central

PMC publication ID

12 August 2017

Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Neurofilaments: structure, metabolism and implications in disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Calcium-activated neutral protease and its endogenous inhibitor. Activation at the cell membrane and biological function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Kinetic properties of the [Ca2+ + Mg2+]-ATPase in Alzheimer and normal fibroblasts at low free calcium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Glutamate neurotoxicity and diseases of the nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

The ultrastructural localization of calcium-activated protease "calpain" in rat brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Molecular insights into Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Calcium-activated neutral proteinases as regulators of cellular function. Implications for Alzheimer's disease pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Intracellular regulatory system involving calpain and calpastatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

The role of calcium regulation in brain aging: reexamination of a hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Identification of the proteolytically activated form of protein kinase C in stimulated human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Increased immunoreactivity of brain spectrin in Alzheimer disease: a marker for synapse loss?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Calcium activated neutral protease--structure-function relationship and functional implications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Protein kinases and phosphorylation in neurologic disorders and cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Membrane resealing in cultured rat septal neurons after neurite transection: evidence for enhancement by Ca(2+)-triggered protease activity and cytoskeletal disassembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Inhibition of proteolysis protects hippocampal neurons from ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Possible roles ofl-phosphoserine in the pathogenesis of Alzheimer’s disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Decreased levels of soluble amyloid beta-protein precursor in cerebrospinal fluid of live Alzheimer disease patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Choline metabolism as a basis for the selective vulnerability of cholinergic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Purification of two spectrin-binding proteins: biochemical and electron microscopic evidence for site-specific reassociation between spectrin and bands 2.1 and 4.1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

1 October 2017

Diminished mitogen-induced calcium uptake by lymphocytes from Alzheimer patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Hydrolytic and autolytic behavior of two forms of calcium-activated neutral protease (CANP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Neuropathological classification of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Synaptic loss in Alzheimer's disease and other dementias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Calpain I remains intact and intracellular during platelet activation. Immunochemical measurements with monoclonal and polyclonal antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Aging-related increases in voltage-sensitive, inactivating calcium currents in rat hippocampus. Implications for mechanisms of brain aging and Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Modulation of erythrocyte Ca2+-ATPase by selective calpain cleavage of the calmodulin-binding domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Calpain I activation is not correlated with aggregation in human platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Calpain and calpastatin in normal and Alzheimer-degenerated human brain tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Regulation of the calcium-activated neutral proteinase (CANP) of bovine brain by myelin lipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Development of hippocampal long-term potentiation is reduced by recently introduced calpain inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Immunohistochemical distribution of calcium-activated neutral proteinases and endogenous CANP inhibitor in the rabbit hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Comparison of Ca(2+)-activated proteinase enzyme and endogenous inhibitor activity in brain tissue from normal and Alzheimer's disease cases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Increased spectrin proteolysis in fibroblasts from aged and Alzheimer donors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Band 3 protein degradation by calpain is enhanced in erythrocytes of old people

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Increased cytosolic free calcium in lymphocytes of Alzheimer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Immunoassay and activity of calcium-activated neutral proteinase (mCANP): distribution in soluble and membrane-associated fractions in human and mouse brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

2 July 2018

Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

22 September 2018

Protease inhibitors reduce the loss of nerve terminals induced by activity and calcium in developing rat soleus muscles in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

22 September 2018

Activation by hemoglobin of the Ca2+-requiring neutral proteinase of human erythrocytes: Structural requirements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46148

22 September 2018

Proteolysis of protein kinase C by calpain: effect of acidic phospholipids

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autolysis of Calcium-Activated Neutral Protease of Chicken Skeletal Muscle1

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and Characterization of a Calcium-Activated Neutral Protease from Rabbit Skeletal Muscle which Requires Calcium Ions of μM Order Concentration

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered calcium uptake in cultured skin fibroblasts from patients with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding to erythrocyte membrane is the physiological mechanism for activation of Ca2+-dependent neutral proteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diagnosis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain-calpastatin and fusion. Fusibility of erythrocytes is determined by a protease-protease inhibitor [calpain-calpastatin] balance

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of a monoclonal anti-calpain antibody on responses of stimulated human neutrophils. Evidence for a role for proteolytically modified protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of inhibitors of protein kinase C and calpain in experimental delayed cerebral vasospasm

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of intracellular calcium-activated neutral proteinase in erythrocytes and its inhibition by exogenously added inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8464868

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.90.7.2628

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

1993PNAS...90.2628S

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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