Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease (Q36031947)

11 August 2017

Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease (English)

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11 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27231155%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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7 June 2020

Rebecca A Barnard

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7 June 2020

Ryan J Hansen

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7 June 2020

Andrew Thorburn

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7 June 2020

Daniel L Gustafson

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7 June 2020

language of work or name

English

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publication date

26 May 2016

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Journal of Pharmacology and Experimental Therapeutics

11 August 2017

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7 June 2020

volume

358

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7 June 2020

issue

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7 June 2020

page(s)

282-293

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Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion

7 June 2020

cites work

1 reference

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A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

2 October 2017

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Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma

2 October 2017

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Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma

2 October 2017

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Phase I clinical trial and pharmacodynamic evaluation of combination hydroxychloroquine and doxorubicin treatment in pet dogs treated for spontaneously occurring lymphoma

2 October 2017

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Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors

2 October 2017

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Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma

2 October 2017

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STAT3-mediated autophagy dependence identifies subtypes of breast cancer where autophagy inhibition can be efficacious

2 October 2017

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Autophagy-dependent production of secreted factors facilitates oncogenic RAS-driven invasion

2 October 2017

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Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells

2 October 2017

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Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

2 October 2017

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Autophagy modulates cell migration and β1 integrin membrane recycling

2 October 2017

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Platinum compounds in children with cancer: toxicity and clinical management

2 October 2017

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Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cells

2 October 2017

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Stromal cell-derived factor-1β mediates cell survival through enhancing autophagy in bone marrow-derived mesenchymal stem cells.

2 October 2017

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Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?

2 October 2017

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Inhibition of autophagy impairs tumor cell invasion in an organotypic model

2 October 2017

1 reference

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Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency

2 October 2017

1 reference

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Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation

2 October 2017

1 reference

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Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy

2 October 2017

1 reference

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Platinum-based compounds for the treatment of metastatic breast cancer

2 October 2017

1 reference

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Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice

2 October 2017

1 reference

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Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome

2 October 2017

1 reference

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Pathophysiological role of autophagy: lesson from autophagy-deficient mouse models

2 October 2017

1 reference

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PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment

2 October 2017

1 reference

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Principles and current strategies for targeting autophagy for cancer treatment

2 October 2017

1 reference

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The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts.

2 October 2017

1 reference

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Dissecting the dynamic turnover of GFP-LC3 in the autolysosome

2 October 2017

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Methods in mammalian autophagy research

2 October 2017

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Autophagy and metastasis: another double-edged sword

2 October 2017

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CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages

2 October 2017

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Induction of autophagy during extracellular matrix detachment promotes cell survival

2 October 2017

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How to interpret LC3 immunoblotting

2 October 2017

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

2 October 2017

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

2 October 2017

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Treatment of metastatic malignant melanoma

2 October 2017

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A new mathematical model for relative quantification in real-time RT-PCR

2 October 2017

1 reference

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Establishment and characterization of a murine osteosarcoma cell line (LM8) with high metastatic potential to the lung

2 October 2017

1 reference

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Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor

2 October 2017

1 reference

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Biological behavior of malignant melanoma cells correlated to their survival in vivo

2 October 2017

1 reference

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When cytoprotective autophagy isn't… and even when it is.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959099

Use of nude mouse xenografts as preclinical drug screens: in vivo activity of established chemotherapeutic agents against melanoma and ovarian carcinoma xenografts.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959099

Autophagy in endothelial progenitor cells is cytoprotective in hypoxic conditions

11 July 2018

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Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells

23 September 2018

1 reference

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A high-performance liquid chromatographic assay for determination of cisplatin in plasma, cancer cell, and tumor samples.

23 September 2018

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Translational evidence that impaired autophagy contributes to arterial ageing

23 September 2018

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12 December 2020

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells

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12 December 2020

Ip cisplatin in patients with malignant ascites: pharmacokinetic evaluation and comparison with the iv route

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A model for ultrafilterable plasma platinum disposition in patients treated with cisplatin

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12 December 2020

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12 December 2020

Comparative pharmacokinetics of cisplatin and three analogues in mice and humans

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12 December 2020

Identifiers

DOI

10.1124/JPET.116.233908

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27231155%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27231155%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

27231155

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27231155%20AND%20SRC:MED&resulttype=core&format=json