Reversal of human cellular senescence: roles of the p53 and p16 pathways (Q35561999)

8 August 2017

title

Reversal of human cellular senescence: roles of the p53 and p16 pathways (English)

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8 August 2017

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Masashi Narita

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Judith Campisi

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8 August 2017

author name string

Christian M Beauséjour

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8 August 2017

Ana Krtolica

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8 August 2017

Francesco Galimi

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8 August 2017

Scott W Lowe

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8 August 2017

Paul Yaswen

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8 August 2017

language of work or name

English

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publication date

1 August 2003

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8 August 2017

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

4212-4222

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

8 August 2017

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Retinoblastoma protein meets chromatin

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Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

12 July 2018

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Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

12 July 2018

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Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies

12 July 2018

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12 July 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

12 July 2018

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

12 July 2018

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The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts

12 July 2018

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Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

12 July 2018

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

12 July 2018

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Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA

12 July 2018

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The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen

12 July 2018

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12 July 2018

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Increased activity of p53 in senescing fibroblasts

12 July 2018

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A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

12 July 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

12 July 2018

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Serum-free growth of human mammary epithelial cells: rapid clonal growth in defined medium and extended serial passage with pituitary extract

12 July 2018

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

12 July 2018

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Reinitiation of host DNA synthesis in senescent human diploid cells by infection with simian virus 40

12 July 2018

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Isolation of a transforming sequence from a human bladder carcinoma cell line

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Mitogenic effects of the proto-oncogene and oncogene forms of c-H-ras DNA in human diploid fibroblasts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Reinitiation of cellular DNA synthesis in BrdU-selected nondividing senescent WI-38 cells by simian virus 40 infection

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Modulation of p53 protein expression during cellular transformation with simian virus 40

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Telomeres shorten during ageing of human fibroblasts

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Structure and function of simian virus 40 large tumor antigen

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Effects of simian virus 40 T-antigens on normal human mammary epithelial cells reveal evidence for spontaneous alterations in addition to loss of p16(INK4a) expression.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

Relative mitogenic activities of wild-type and retinoblastoma binding-defective SV40 T antigens in serum-deprived and senescent human diploid fibroblasts.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=175806

A role for both RB and p53 in the regulation of human cellular senescence

26 September 2018

1 reference

12 December 2020

CELL BIOLOGY: Enhanced: Telomere Capping--One Strand Fits All

1 reference

12 December 2020

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

12 December 2020

Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase

1 reference

12 December 2020

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

12 December 2020

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/CDG417

1 reference

8 August 2017

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8 August 2017

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