Protein kinase Cα as a heart failure therapeutic target (Q35480691)

8 August 2017

title

Protein kinase Cα as a heart failure therapeutic target (English)

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8 August 2017

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Jeffery D Molkentin

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Qinghang Liu

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8 August 2017

publication date

16 October 2010

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Journal of Molecular and Cellular Cardiology

8 August 2017

published in

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

474-478

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G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C.

8 August 2017

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Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

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Protein kinase C in heart failure: a therapeutic target?

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PKCalpha regulates platelet granule secretion and thrombus formation in mice

12 July 2018

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The PKC inhibitor AEB071 may be a therapeutic option for psoriasis.

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Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure

12 July 2018

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PKC isozymes in chronic cardiac disease: possible therapeutic targets?

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Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial

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Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure

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Convergence of protein kinase C and JAK-STAT signaling on transcription factor GATA-4.

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PKC-alpha regulates cardiac contractility and propensity toward heart failure

12 July 2018

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Manipulating cardiac contractility in heart failure: data from mice and men.

12 July 2018

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Protein Kinase Cα Negatively Regulates Systolic and Diastolic Function in Pathological Hypertrophy

12 July 2018

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Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure

12 July 2018

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Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T

12 July 2018

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Long-term expression of protein kinase C in adult mouse hearts improves postischemic recovery

12 July 2018

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Ischemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity

12 July 2018

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Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immunofluorescence microscopy analysis.

12 July 2018

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12 July 2018

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PKCbeta modulates ischemia-reperfusion injury in the heart

12 July 2018

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PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility

26 September 2018

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(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta

26 September 2018

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Protein kinase C contains a pseudosubstrate prototope in its regulatory domain

26 September 2018

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Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1

7 January 2021

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Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms and in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity

7 January 2021

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Increased protein kinase C and isozyme redistribution in pressure-overload cardiac hypertrophy in the rat

7 January 2021

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PKC translocation without changes in Galphaq and PLC-beta protein abundance in cardiac hypertrophy and failure

7 January 2021

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Calcineurin Promotes Protein Kinase C and c-Jun NH2-terminal Kinase Activation in the Heart

7 January 2021

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Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy

7 January 2021

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Protein kinase C in the human heart: differential regulation of the isoforms in aortic stenosis or dilated cardiomyopathy

7 January 2021

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Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Genetic and phenotypic targeting of β-adrenergic signaling in heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

Calcineurin promotes protein kinase C and c-Jun NH2-terminal kinase activation in the heart. Cross-talk between cardiac hypertrophic signaling pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2010.10.004

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.YJMCC.2010.10.004

1 reference

8 August 2017

1 reference

8 August 2017

1 reference