Importazole, a small molecule inhibitor of the transport receptor importin-β (Q35109174)

6 August 2017

title

Importazole, a small molecule inhibitor of the transport receptor importin-β (English)

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6 August 2017

Karsten Weis

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Rebecca Heald

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Jonathan F Soderholm

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6 August 2017

Stephen L Bird

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6 August 2017

Petr Kalab

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6 August 2017

Yasaswini Sampathkumar

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6 August 2017

Keisuke Hasegawa

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6 August 2017

Michael Uehara-Bingen

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6 August 2017

publication date

21 April 2011

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6 August 2017

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

700-708

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Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport

6 August 2017

cites work

1 reference

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Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking

9 July 2018

1 reference

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Identification of a small molecule inhibitor of importin β mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries.

9 July 2018

1 reference

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Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP

9 July 2018

1 reference

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Regulated degradation of spindle assembly factors by the anaphase-promoting complex.

9 July 2018

1 reference

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Differential scanning fluorimetry measurement of protein stability changes upon binding to glycosaminoglycans: a screening test for binding specificity

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Design of peptide inhibitors for the importin alpha/beta nuclear import pathway by activity-based profiling

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Highly sensitive and quantitative FRET-FLIM imaging in single dendritic spines using improved non-radiative YFP

9 July 2018

1 reference

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Tumor cell dependence on Ran-GTP-directed mitosis

9 July 2018

1 reference

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

9 July 2018

1 reference

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A detergent-based assay for the detection of promiscuous inhibitors

9 July 2018

1 reference

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The karyopherin Kap95 regulates nuclear pore complex assembly into intact nuclear envelopes in vivo

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Analysis of a RanGTP-regulated gradient in mitotic somatic cells

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Structural basis for nuclear import complex dissociation by RanGTP

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Importin beta: conducting a much larger cellular symphony

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Importin β Negatively Regulates Nuclear Membrane Fusion and Nuclear Pore Complex Assembly

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

RanGTP mediates nuclear pore complex assembly

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Importin-beta-like nuclear transport receptors

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Role of importin-beta in coupling Ran to downstream targets in microtubule assembly

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Importin beta is a mitotic target of the small GTPase Ran in spindle assembly

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Evidence for a role of CRM1 in signal-mediated nuclear protein export

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear import factor p97

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Identification of different roles for RanGDP and RanGTP in nuclear protein import

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Conserved histidine residues of RCC1 are essential for nucleotide exchange on Ran.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

A novel receptor-mediated nuclear protein import pathway

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4.

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factors

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Mitotic spindle organization by a plus-end-directed microtubule motor

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Investigating mitotic spindle assembly and function in vitro using Xenopus laevis egg extracts

9 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Determining the position of the cell division plane

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3137676

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

27 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21469738

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21469738

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/CB2000296

1 reference

6 August 2017

1 reference

6 August 2017

1 reference