Novel chemical genetic approaches to the discovery of signal transduction inhibitors (Q35053197)

6 August 2017

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title

Novel chemical genetic approaches to the discovery of signal transduction inhibitors (English)

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6 August 2017

Kevan Shokat

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6 August 2017

Mark Velleca

series ordinal

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6 August 2017

publication date

1 August 2002

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6 August 2017

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

872-879

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Chemogenomic approaches to drug discovery

6 August 2017

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Controlling Signal Transduction with Synthetic Ligands

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A chemical switch for inhibitor-sensitive alleles of any protein kinase

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Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme

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A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway

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Engineering of the myosin-ibeta nucleotide-binding pocket to create selective sensitivity to N(6)-modified ADP analogs

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Identifiers

DOI

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6 August 2017

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