The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans. (Q35026396)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12483515%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

review article

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title

The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12483515%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12483515%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

Mary Ellen Moynahan

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5 August 2017

language of work or name

English

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publication date

1 December 2002

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15 December 2019

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15 December 2019

volume

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15 December 2019

issue

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15 December 2019

page(s)

8994-9007

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BRCA1 and BRCA2 mutations in a population-based study of male breast cancer

15 December 2019

cites work

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The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

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Cancer risks in BRCA2 mutation carriers

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On the use of familial aggregation in population-based case probands for calculating penetrance

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BRCA2-null embryonic survival is prolonged on the BALB/c genetic background.

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Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency

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Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice

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Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

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7 January 2021

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

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Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice

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p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

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7 January 2021

Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

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7 January 2021

Roles of BRCA1 in centrosome duplication

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Knockout mouse models and mammary tumorigenesis

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Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

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Cancer risks in BRCA1 carriers: time for the next generation of studies

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7 January 2021

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

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7 January 2021

Animal models of tumor-suppressor genes.

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7 January 2021

Linkage of early-onset familial breast cancer to chromosome 17q21

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7 January 2021

Gene-Expression Profiles in Hereditary Breast Cancer

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7 January 2021

A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage.

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7 January 2021

Distinctive patterns of Her-2/neu, c-myc, and cyclin D1 gene amplification by fluorescence in situ hybridization in primary human breast cancers

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7 January 2021

Gene expression profiles of BRCA1-linked, BRCA2-linked, and sporadic ovarian cancers

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7 January 2021

CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation.

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7 January 2021

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

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7 January 2021

Heterozygosity for a mutation in Brca1 or Atm does not increase susceptibility to ENU-induced mammary tumors in Apc(Min)/+ mice

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7 January 2021

Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome

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7 January 2021

The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2.

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7 January 2021

hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

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7 January 2021

A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers

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7 January 2021

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

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7 January 2021

Tumorigenesis in mice carrying a truncating Brca1 mutation

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7 January 2021

Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice

1 reference

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7 January 2021

BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets

1 reference

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7 January 2021

Brca1 required for T cell lineage development but not TCR loci rearrangement.

1 reference

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7 January 2021

Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis

1 reference

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7 January 2021

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

Participation of BRCA1 in the DNA repair response...via transcription

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

Brca1 controls homology-directed DNA repair

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7 January 2021

BRCA2 is required for homology-directed repair of chromosomal breaks

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7 January 2021

Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer

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7 January 2021

Association of BRCA1 with Rad51 in mitotic and meiotic cells

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7 January 2021

Weekly trastuzumab and paclitaxel therapy for metastatic breast cancer with analysis of efficacy by HER2 immunophenotype and gene amplification.

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7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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7 January 2021

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

1 reference

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7 January 2021

Solid variant of mammary adenoid cystic carcinoma with basaloid features: a study of nine cases

1 reference

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7 January 2021

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

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7 January 2021

Cancer Incidence in BRCA1 mutation carriers

1 reference

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7 January 2021

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

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7 January 2021

Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation

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7 January 2021

Gene expression profiling predicts clinical outcome of breast cancer

1 reference

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7 January 2021

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

BRCA1 and BRCA2 and the genetics of breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

BRCA1 transcriptionally regulates genes involved in breast tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206177

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206177

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12483515%20AND%20SRC:MED&resulttype=core&format=json

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15 December 2019

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24 November 2022

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