Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction (Q35002481)

5 August 2017

title

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction (English)

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5 August 2017

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J M Olefsky

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5 August 2017

D W Rose

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5 August 2017

A R Saltiel

series ordinal

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5 August 2017

M Majumdar

series ordinal

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5 August 2017

S J Decker

series ordinal

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5 August 2017

language of work or name

English

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publication date

1 January 1994

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Proceedings of the National Academy of Sciences of the United States of America

5 August 2017

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inferred from page(s)

published in

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

797-801

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The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains

5 August 2017

cites work

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

Purification and characterization of human H-ras proteins expressed in Escherichia coli

8 July 2018

1 reference

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A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

8 July 2018

1 reference

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Microinjection of transforming ras protein induces c-fos expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

The insulin receptor and the molecular mechanism of insulin action

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

Augmented mitogenesis and impaired metabolic signaling mediated by a truncated insulin receptor.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

Dissection of the growth versus metabolic effects of insulin and insulin-like growth factor-I in transfected cells expressing kinase-defective human insulin receptors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

Cellular expression of mutant insulin receptors interferes with the rapid transcriptional response to both insulin and insulin-like growth factor I.

8 July 2018

1 reference

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The jun and fos protein families are both required for cell cycle progression in fibroblasts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

The mitogen-activated protein kinase activator

8 July 2018

1 reference

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Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis

8 July 2018

1 reference

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SH2 and SH3 domains: from structure to function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

The association of insulin-elicited phosphotyrosine proteins with src homology 2 domains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=43036

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase

8 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8290602

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8290602

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/8290602

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.91.2.797

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5 August 2017

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5 August 2017

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