The immunology of susceptibility and resistance to Leishmania major in mice (Q34988360)

5 August 2017

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title

The immunology of susceptibility and resistance to Leishmania major in mice (English)

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5 August 2017

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David Sacks

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5 August 2017

Nancy Noben-Trauth

series ordinal

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5 August 2017

publication date

1 November 2002

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Nature Reviews Immunology

5 August 2017

published in

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

845-858

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Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism

5 August 2017

cites work

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IL-4-deficient Balb/c mice resist infection with Leishmania major

31 March 2020

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IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

31 March 2020

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In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease

31 March 2020

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Resistance to Leishmania major induced by tolerance to a single antigen

31 March 2020

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Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major.

31 March 2020

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T cell and non-T cell compartments can independently determine resistance to Leishmania major

31 March 2020

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TH1 and TH2 cell antigen receptors in experimental leishmaniasis

31 March 2020

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Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo

31 March 2020

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A natural model of Leishmania major infection reveals a prolonged "silent" phase of parasite amplification in the skin before the onset of lesion formation and immunity.

31 March 2020

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Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection

31 March 2020

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Early IL-4 production does not predict susceptibility to Leishmania major

31 March 2020

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Susceptibility to Leishmania major in IL-4 transgenic mice is not correlated with the lack of a Th1 immune response

31 March 2020

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Interleukin-4 transgenic mice of resistant background are susceptible to Leishmania major infection

31 March 2020

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Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

31 March 2020

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Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity

31 March 2020

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Recombinant interleukin 12 cures mice infected with Leishmania major

31 March 2020

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Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response

31 March 2020

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Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

31 March 2020

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Maintenance of IL-12-responsive CD4+ T cells during a Th2 response in Leishmania major-infected mice

31 March 2020

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Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development

31 March 2020

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BALB/c mice bearing a transgenic IL-12 receptor beta 2 gene exhibit a nonhealing phenotype to Leishmania major infection despite intact IL-12 signaling

31 March 2020

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An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major

31 March 2020

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Early parasite containment is decisive for resistance to Leishmania major infection.

31 March 2020

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CD4+ and/or gammadelta+ T cells in the liver spontaneously produce IL-4 in vitro during the early phase of Leishmania major infection in susceptible BALB/c mice

31 March 2020

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The influence of the site of parasite inoculation on the development of Th1 and Th2 type immune responses in (BALB/c x C57BL/6) F1 mice infected with Leishmania major.

31 March 2020

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Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo

31 March 2020

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Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1

31 March 2020

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CTLA4 (CD152) modulates the Th subset response and alters the course of experimental Leishmania major infection

31 March 2020

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Blockade of CD86 ameliorates Leishmania major infection by down-regulating the Th2 response

31 March 2020

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Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis

31 March 2020

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Leishmania major-infected murine Langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis

31 March 2020

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Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major.

31 March 2020

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Intravenous injection of irradiated Leishmania major into susceptible BALB/c mice: immunization or protective tolerance

31 March 2020

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Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice

31 March 2020

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Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes.

31 March 2020

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IL-13 is a susceptibility factor for Leishmania major infection.

31 March 2020

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Susceptibility to Leishmania major infection in interleukin-4-deficient mice

31 March 2020

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Expression of Th2 cytokines and the stable Th2 marker ST2L in the absence of IL-4 during Leishmania major infection

31 March 2020

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Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation

31 March 2020

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Experimental Leishmania major infection in mice: role of IL-10

31 March 2020

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Administration of plasmids expressing interleukin-4 and interleukin-10 causes BALB/c mice to induce a T helper 2-type response despite the expected T helper 1-type response with a low-dose infection of Leishmania major.

31 March 2020

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The role of IL-10 in promoting disease progression in leishmaniasis

31 March 2020

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Certified professionals: CD4(+)CD25(+) suppressor T cells

31 March 2020

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Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infection

31 March 2020

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In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma

31 March 2020

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High levels of plasma IL-10 and expression of IL-10 by keratinocytes during visceral leishmaniasis predict subsequent development of post-kala-azar dermal leishmaniasis

31 March 2020

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CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major

31 March 2020

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Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells

31 March 2020

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CD40 ligand is required for protective cell-mediated immunity to Leishmania major

31 March 2020

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Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity

31 March 2020

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Mice from a genetically resistant background lacking the interferon gamma receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response

31 March 2020

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STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis

31 March 2020

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Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection

31 March 2020

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WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection

31 March 2020

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IL-12 is required to maintain a Th1 response during Leishmania major infection.

31 March 2020

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The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge

31 March 2020

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Il-12: keeping cell-mediated immunity alive

31 March 2020

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Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice

31 March 2020

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Parasitism of epidermal Langerhans cells in experimental cutaneous leishmaniasis with Leishmania major

31 March 2020

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Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity

31 March 2020

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Murine dendritic cells internalize Leishmania major promastigotes, produce IL-12 p40 and stimulate primary T cell proliferation in vitro.

31 March 2020

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Dendritic cells induce immunity to cutaneous leishmaniasis in mice.

31 March 2020

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Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells

31 March 2020

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CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 c

31 March 2020

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Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice

31 March 2020

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Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development

31 March 2020

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Tumor necrosis factor-alpha in combination with interferon-gamma, but not with interleukin 4 activates murine macrophages for elimination of Leishmania major amastigotes

31 March 2020

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Altered immune responses in mice lacking inducible nitric oxide synthase

31 March 2020

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Rapidly fatal leishmaniasis in resistant C57BL/6 mice lacking TNF.

31 March 2020

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The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity

31 March 2020

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Class II major histocompatibility complex-deficient mice initially control an infection with Leishmania major but succumb to the disease

31 March 2020

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Leishmania major infection in major histocompatibility complex class II-deficient mice: CD8+ T cells do not mediate a protective immune response

31 March 2020

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Role of T cell subsets during the recall of immunologic memory to Leishmania major

31 March 2020

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Involvement of specific Lyt-2+ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis

31 March 2020

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CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major.

31 March 2020

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Characterization of the local and systemic immune responses in patients with cutaneous leishmaniasis due to Leishmania major

31 March 2020

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Fibroblasts as host cells in latent leishmaniosis

31 March 2020

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Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase

31 March 2020

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The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure.

31 March 2020

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Immunologic determinants of disease evolution in localized cutaneous leishmaniasis due to Leishmania major

31 March 2020

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Distinct innate and acquired immune responses to Leishmania in putative susceptible and resistant human populations endemically exposed to L. (Viannia) panamensis infection

31 March 2020

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Leishmania-specific T cells expressing interferon-gamma (IFN-gamma) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis

31 March 2020

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Immune elimination of Leishmania major in mice: implications for immune memory, vaccination, and reactivation disease

31 March 2020

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Experiences with vaccines against cutaneous leishmaniasis: of men and mice

31 March 2020

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Randomised vaccine trial of single dose of killed Leishmania major plus BCG against anthroponotic cutaneous leishmaniasis in Bam, Iran.

31 March 2020

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A randomised, double-blind, controlled trial of a killed L. major vaccine plus BCG against zoonotic cutaneous leishmaniasis in Iran

31 March 2020

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Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection

31 March 2020

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The potency and durability of DNA- and protein-based vaccines against Leishmania major evaluated using low-dose, intradermal challenge.

31 March 2020

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Vaccines against intracellular infections requiring cellular immunity

31 March 2020

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The immunomodulatory factors of bloodfeeding arthropod saliva

31 March 2020

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Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis

31 March 2020

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Protection Against Cutaneous Leishmaniasis Resulting from Bites of Uninfected Sand Flies

31 March 2020

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Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein

31 March 2020

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Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection

31 March 2020

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Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica

31 March 2020

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Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens

31 March 2020

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Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets

31 March 2020

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Genetic control of Leishmania major infection in congenic, recombinant inbred and F2 populations of mice.

31 March 2020

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Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guérin expressing the Leishmania surface proteinase gp63

31 March 2020

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Long-term protection of mice against Leishmania major with a synthetic peptide vaccine

31 March 2020

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Expression cloning of a protective Leishmania antigen

31 March 2020

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Vaccination with plasmid DNA encoding TSA/LmSTI1 leishmanial fusion proteins confers protection against Leishmania major infection in susceptible BALB/c mice

31 March 2020

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A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major

31 March 2020

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The protective capacities of histone H1 against experimental murine cutaneous leishmaniasis

31 March 2020

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CD4(+) T cells which react to the Leishmania major LACK antigen rapidly secrete interleukin-4 and are detrimental to the host in resistant B10.D2 mice.

31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI933

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5 August 2017

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