The macrophage foam cell as a target for therapeutic intervention (Q34986351)

5 August 2017

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title

The macrophage foam cell as a target for therapeutic intervention (English)

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5 August 2017

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Christopher K Glass

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5 August 2017

Andrew C Li

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5 August 2017

language of work or name

English

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publication date

1 November 2002

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5 August 2017

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

1235-1242

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Toll-like receptors: critical proteins linking innate and acquired immunity

5 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

The role of scavenger receptors in the innate immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Molecular immunobiology of macrophages: recent progress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Inflammation and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Atherosclerosis. the road ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Atherosclerosis — An Inflammatory Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Class A scavenger receptors, macrophages, and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Immune mechanisms in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Compensatory enlargement of human atherosclerotic coronary arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

New anti-monocyte chemoattractant protein-1 gene therapy attenuates atherosclerosis in apolipoprotein E-knockout mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM1102-1235

Subendothelial retention of atherogenic lipoproteins in early atherosclerosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM1102-1235

Mechanisms for oxidizing low-density lipoprotein. Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM1102-1235

Phagocytes and oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM1102-1235

Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Paradoxical reduction of fatty streak formation in mice lacking endothelial nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Inducible nitric oxide synthase deficiency does not affect the susceptibility of mice to atherosclerosis but increases collagen content in lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Mice lacking inducible nitric oxide synthase develop spontaneous hypercholesterolaemia and aortic atheromas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Increased atherosclerosis in myeloperoxidase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Angiotensin II increases macrophage-mediated modification of low density lipoprotein via a lipoxygenase-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

The angiotensin-converting enzyme inhibitor, fosinopril, and the angiotensin II receptor antagonist, losartan, inhibit LDL oxidation and attenuate atherosclerosis independent of lowering blood pressure in apolipoprotein E deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Identification of scavenger receptor SR-BI as a high density lipoprotein receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

The lipid-laden foam cell: an elusive target for therapeutic intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Acyl-CoA:cholesterol acyltransferase inhibition reduces atherosclerosis in apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Tangier disease as a test of the reverse cholesterol transport hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Increased ABCA1 activity protects against atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Lipoprotein lipase: physiology, biochemistry, and molecular biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

The pivotal role of lipoprotein lipase in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Unsaturated fatty acids inhibit cholesterol efflux from macrophages by increasing degradation of ATP-binding cassette transporter A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Lymphocytes are important in early atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Immunological responses to oxidized LDL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Interferon-gamma induces downregulation of Tangier disease gene (ATP-binding-cassette transporter 1) in macrophage-derived foam cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

IFN-gamma potentiates atherosclerosis in ApoE knock-out mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient Mice by altering lymphocyte and macrophage phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Immunomodulatory effects of statins: mechanisms and potential impact on arteriosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Generation of C-reactive protein and complement components in atherosclerotic plaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Peroxisome proliferator-activated receptor gamma and metabolic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Roles of peroxisome proliferator-activated receptor gamma in lipid homeostasis and inflammatory responses of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Protective Role of Interleukin-10 in Atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

Macrophage scavenger receptors and foam cell formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

Adhesion of monocytes to arterial endothelium and initiation of atherosclerosis are critically dependent on vascular cell adhesion molecule-1 gene dosage

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

Scavenger receptor-BI inhibits ATP-binding cassette transporter 1- mediated cholesterol efflux in macrophages

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

Increased ABCA1 activity protects against atherosclerosis.

1 reference

https://api.crossref.org/works/10.1038%2FNM1102-1235

7 January 2021

Identifiers

DOI

10.1038/NM1102-1235

1 reference

5 August 2017

1 reference