CD40 and its viral mimic, LMP1: similar means to different ends (Q34980894)

5 August 2017

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title

CD40 and its viral mimic, LMP1: similar means to different ends (English)

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5 August 2017

Ngan Lam

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5 August 2017

Bill Sugden

series ordinal

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5 August 2017

publication date

1 January 2003

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5 August 2017

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inferred from page(s)

published in

Cellular Signalling

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5 August 2017

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5 August 2017

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5 August 2017

page(s)

9-16

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Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50

5 August 2017

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7 January 2021

Functions of CD40 on B cells, dendritic cells and other cells

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7 January 2021

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

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7 January 2021

Immune regulation by CD40-CD40-l interactions - 2; Y2K update

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7 January 2021

Biology and disease associations of Epstein-Barr virus

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7 January 2021

Epstein-Barr virus-mediated B-cell proliferation is dependent upon latent membrane protein 1, which simulates an activated CD40 receptor

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7 January 2021

Modularity in the TNF-receptor family

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7 January 2021

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling

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7 January 2021

Regulation of CD40 function by its isoforms generated through alternative splicing

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7 January 2021

2 A crystal structure of an extracellular fragment of human CD40 ligand

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7 January 2021

Heteromultimeric complexes of CD40 ligand are present on the cell surface of human T lymphocytes

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7 January 2021

Recombinant soluble trimeric CD40 ligand is biologically active

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7 January 2021

Human native soluble CD40L is a biologically active trimer, processed inside microsomes

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7 January 2021

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

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7 January 2021

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

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7 January 2021

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

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7 January 2021

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

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7 January 2021

Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM

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7 January 2021

Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM.

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7 January 2021

The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

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7 January 2021

Mice deficient for the CD40 ligand

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7 January 2021

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

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7 January 2021

The many roles of CD40 in cell-mediated inflammatory responses

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7 January 2021

Cutting edge: Th2 response induction by dendritic cells: a role for CD40

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7 January 2021

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

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7 January 2021

CD40 is expressed and functional on neuronal cells

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7 January 2021

Mimicry of CD40 signals by Epstein-Barr virus LMP1 in B lymphocyte responses

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7 January 2021

Latent membrane protein 1 of Epstein-Barr virus mimics a constitutively active receptor molecule.

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7 January 2021

An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells.

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7 January 2021

Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice

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7 January 2021

A CD40 Signalosome anchored in lipid rafts leads to constitutive activation of NF-kappaB and autonomous cell growth in B cell lymphomas

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7 January 2021

Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis

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7 January 2021

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

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7 January 2021

CD40 induces apoptosis in carcinoma cells through activation of cytotoxic ligands of the tumor necrosis factor superfamily

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7 January 2021

The bfl-1 gene is transcriptionally upregulated by the Epstein-Barr virus LMP1, and its expression promotes the survival of a Burkitt's lymphoma cell line

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7 January 2021

The amino-terminus and membrane-spanning domains of LMP-1 inhibit cell proliferation

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7 January 2021

Latent membrane protein 1 of Epstein-Barr virus inhibits as well as stimulates gene expression

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7 January 2021

Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells

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7 January 2021

Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade

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7 January 2021

Activation of the p38 mitogen-activated protein kinase pathway by Epstein-Barr virus-encoded latent membrane protein 1 coregulates interleukin-6 and interleukin-8 production

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7 January 2021

RelB nuclear translocation mediated by C-terminal activator regions of Epstein-Barr virus-encoded latent membrane protein 1 and its effect on antigen-presenting function in B cells

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7 January 2021

Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes

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7 January 2021

Characterization of intercellular adhesion molecule-1 regulation by Epstein-Barr virus-encoded latent membrane protein-1 identifies pathways that cooperate with nuclear factor kappa B to activate transcription

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7 January 2021

Role of the TRAF binding site and NF-kappaB activation in Epstein-Barr virus latent membrane protein 1-induced cell gene expression

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7 January 2021

Glycoprotein gp110 of Epstein-Barr virus determines viral tropism and efficiency of infection

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7 January 2021

In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction

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7 January 2021

Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling

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7 January 2021

CD40 signaling in human dendritic cells is initiated within membrane rafts

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7 January 2021

CD40 and LMP-1 both signal from lipid rafts but LMP-1 assembles a distinct, more efficient signaling complex

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7 January 2021

Evidence of LMP1-TRAF3 interactions in glycosphingolipid-rich complexes of lymphoblastoid and nasopharyngeal carcinoma cells

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7 January 2021

Tumor necrosis factor receptor-associated factors (TRAFs)

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7 January 2021

Molecular basis for CD40 signaling mediated by TRAF3

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7 January 2021

Structural basis for self-association and receptor recognition of human TRAF2

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7 January 2021

CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs

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7 January 2021

CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization

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7 January 2021

Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

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7 January 2021

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

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7 January 2021

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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7 January 2021

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

1 reference

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7 January 2021

Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation.

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7 January 2021

Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region

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7 January 2021

High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization

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7 January 2021

Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40

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7 January 2021

Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals

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7 January 2021

The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family

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7 January 2021

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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7 January 2021

The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB

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7 January 2021

A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction

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7 January 2021

Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD.

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7 January 2021

LMP1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF2

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7 January 2021

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

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7 January 2021

Multiple Carboxyl-Terminal Regions of the EBV Oncoprotein, Latent Membrane Protein 1, Cooperatively Regulate Signaling to B Lymphocytes Via TNF Receptor-Associated Factor (TRAF)-Dependent and TRAF-Independent Mechanisms

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7 January 2021

Epstein-Barr virus latent membrane protein-1 (LMP1) signalling is distinct from CD40 and involves physical cooperation of its two C-terminus functional regions

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7 January 2021

TRADD domain of Epstein-Barr virus transforming protein LMP1 is essential for inducing immortalization and suppressing senescence of primary rodent fibroblasts

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7 January 2021

The Epstein-Barr virus LMP1 cytoplasmic carboxy terminus is essential for B-lymphocyte transformation; fibroblast cocultivation complements a critical function within the terminal 155 residues.

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7 January 2021

The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation

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7 January 2021

Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154

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7 January 2021

Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands

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7 January 2021

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling

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7 January 2021

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40

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7 January 2021

Characterization of the roles of TNF receptor-associated factor 6 in CD40-mediated B lymphocyte effector functions

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7 January 2021

TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.

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7 January 2021

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

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7 January 2021

Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation

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7 January 2021

Involvement of CRAF1, a relative of TRAF, in CD40 signaling

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7 January 2021

Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.

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7 January 2021

TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice

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7 January 2021

Upregulation of TRAF-3 by shear stress blocks CD40-mediated endothelial activation

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7 January 2021

Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein

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7 January 2021

TRAF6 is a critical mediator of signal transduction by the viral oncogene latent membrane protein 1

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7 January 2021

Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells

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7 January 2021

Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteins

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7 January 2021

Crystallographic analysis of CD40 recognition and signaling by human TRAF2

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7 January 2021

10.1016/S0898-6568(02)00083-9

Identifiers

DOI

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5 August 2017

1 reference