Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells (Q34695467)

4 August 2017

title

Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells (English)

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4 August 2017

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4 August 2017

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4 August 2017

Nadia A Chuzhanova

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Regina Z Cer

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4 August 2017

Guliang Wang

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4 August 2017

Aklank Jain

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4 August 2017

Karen M Vasquez

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4 August 2017

Jack R Collins

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4 August 2017

Vilhelm A Bohr

series ordinal

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4 August 2017

language of work or name

English

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publication date

1 February 2011

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Journal of Biological Chemistry

4 August 2017

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inferred from page(s)

published in

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4 August 2017

volume

286

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4 August 2017

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4 August 2017

page(s)

10017-10026

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Methylation-mediated deamination of 5-methylcytosine appears to give rise to mutations causing human inherited disease in CpNpG trinucleotides, as well as in CpG dinucleotides

4 August 2017

cites work

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Human DHX9 helicase unwinds triple-helical DNA structures

7 July 2018

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The mutation spectrum revealed by paired genome sequences from a lung cancer patient

7 July 2018

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WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations

7 July 2018

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WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase

7 July 2018

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HO* radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases.

7 July 2018

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Complete ascertainment of intragenic copy number mutations (CNMs) in the CFTR gene and its implications for CNM formation at other autosomal loci

7 July 2018

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Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

7 July 2018

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Vitamin C restores healthy aging in a mouse model for Werner syndrome

7 July 2018

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The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses.

7 July 2018

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Gene conversion causing human inherited disease: evidence for involvement of non-B-DNA-forming sequences and recombination-promoting motifs in DNA breakage and repair

7 July 2018

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Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency

7 July 2018

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Human mutation rate associated with DNA replication timing

7 July 2018

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Models for chromosomal replication-independent non-B DNA structure-induced genetic instability

7 July 2018

1 reference

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DNA structure-induced genomic instability in vivo

7 July 2018

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Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.

7 July 2018

1 reference

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Chromosomal instability mediated by non-B DNA: cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans.

7 July 2018

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FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts

7 July 2018

1 reference

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Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

7 July 2018

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The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

7 July 2018

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Unexpected complexity at breakpoint junctions in phenotypically normal individuals and mechanisms involved in generating balanced translocations t(1;22)(p36;q13)

7 July 2018

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Roles of the Werner syndrome RecQ helicase in DNA replication

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Inhibitory effect of a short Z-DNA forming sequence on transcription elongation by T7 RNA polymerase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

A palindrome-driven complex rearrangement of 22q11.2 and 8q24.1 elucidated using novel technologies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Replication fork stalling at natural impediments

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Non-B DNA conformations formed by long repeating tracts of myotonic dystrophy type 1, myotonic dystrophy type 2, and Friedreich's ataxia genes, not the sequences per se, promote mutagenesis in flanking regions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Enzymatic mechanism of the WRN helicase/nuclease.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

The spectrum of WRN mutations in Werner syndrome patients

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Targeting oncogenes to improve breast cancer chemotherapy

7 July 2018

1 reference

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Genetic variation affects de novo translocation frequency.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Z-DNA-forming sequences generate large-scale deletions in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Sequence dependence of charge transport through DNA domains

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Werner protein protects nonproliferating cells from oxidative DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Advances in mechanisms of genetic instability related to hereditary neurological diseases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Current advances in unraveling the function of the Werner syndrome protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

UVR-induced G-C to C-G transversions from oxidative DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Breakpoints of gross deletions coincide with non-B DNA conformations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Naturally occurring H-DNA-forming sequences are mutagenic in mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Non-B DNA conformations, genomic rearrangements, and human disease

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

A palindrome-mediated mechanism distinguishes translocations involving LCR-B of chromosome 22q11.2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Gene expression profiling in Werner syndrome closely resembles that of normal aging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Loss of Werner syndrome protein function promotes aberrant mitotic recombination

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

A free energy analysis of nucleic acid base stacking in aqueous solution

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Mutator phenotype of Werner syndrome is characterized by extensive deletions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

Use of supF, an Escherichia coli tyrosine suppressor tRNA gene, as a mutagenic target in shuttle-vector plasmids.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060453

The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.

7 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.176636

Extension of the life span in patients with Werner syndrome

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.176636

Functional role of the Werner syndrome RecQ helicase in human fibroblasts.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.176636

In vivo misregulation of genes involved in apoptosis, development and oxidative stress in mice lacking both functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.176636

The Human Gene Mutation Database: 2008 update

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.176636

Absolute rates of hole transfer in DNA.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.176636

The influence of guanine on DNA hole transport efficiency

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.176636

Possible cause of G-C-->C-G transversion mutation by guanine oxidation product, imidazolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.176636

Cruciform-forming inverted repeats appear to have mediated many of the microinversions that distinguish the human and chimpanzee genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.176636

Evidence for a predominant role of oxidative damage in germline mutation in mammals

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.176636

A triplex-forming sequence from the human c-MYC promoter interferes with DNA transcription

21 January 2018

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12 December 2020

Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases

1 reference

12 December 2020

In vivo somatic mutations in Werner's syndrome

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12 December 2020

Linking the metabolism of hydroquinone to its nephrotoxicity and nephrocarcinogenicity

1 reference

12 December 2020

Oxidative Nucleobase Modifications Leading to Strand Scission

1 reference

12 December 2020

Genetic instability and hematologic disease risk in Werner syndrome patients and heterozygotes

1 reference

12 December 2020

GC-->CG transversion mutation might be caused by 8-oxoguanine oxidation product

1 reference

12 December 2020

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

1 reference

12 December 2020

Pkd1 unusual DNA conformations are recognized by nucleotide excision repair

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.176636

1 reference

4 August 2017

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4 August 2017

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