Cyclin D-dependent kinases, INK4 inhibitors and cancer (Q34605533)

3 August 2017

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title

Cyclin D-dependent kinases, INK4 inhibitors and cancer (English)

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3 August 2017

Marcos Malumbres

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Sagrario Ortega

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3 August 2017

Mariano Barbacid

series ordinal

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3 August 2017

language of work or name

English

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publication date

1 March 2002

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Biochimica et Biophysica Acta

3 August 2017

published in

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3 August 2017

volume

1602

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3 August 2017

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3 August 2017

page(s)

73-87

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A Restriction Point for Control of Normal Animal Cell Proliferation

3 August 2017

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G1 phase progression: cycling on cue

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The retinoblastoma protein and cell cycle control

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E2F and cell proliferation: a world turned upside down

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Chromatin remodeling and Rb activity

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7 January 2021

Acetylation control of the retinoblastoma tumour-suppressor protein

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7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

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7 January 2021

Pathways governing G1/S transition and their response to DNA damage

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7 January 2021

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

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7 January 2021

Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27(kip1) and p21(cip1).

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7 January 2021

A family of human cdc2-related protein kinases

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7 January 2021

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

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7 January 2021

Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase

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7 January 2021

Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression

1 reference

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7 January 2021

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

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7 January 2021

Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

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7 January 2021

Distinct roles for cyclin-dependent kinases in cell cycle control

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7 January 2021

The D-type cyclins and their role in tumorigenesis

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7 January 2021

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

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7 January 2021

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

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7 January 2021

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1 reference

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7 January 2021

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1 reference

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7 January 2021

Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

A cell cycle regulator potentially involved in genesis of many tumor types

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

1 reference

7 January 2021

Requirements for cell cycle arrest by p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Requirement of cyclin E-Cdk2 inhibition in p16(INK4a)-mediated growth suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1)

1 reference

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7 January 2021

Ubiquitin/proteasome-mediated degradation of p19INK4d determines its periodic expression during the cell cycle

1 reference

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7 January 2021

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

1 reference

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7 January 2021

Inactivation of p16 in human mammary epithelial cells by CpG island methylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Progressive region-specific de novo methylation of the p16 CpG island in primary human mammary epithelial cell strains during escape from M(0) growth arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

The tumor suppressor protein p16INK4a.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Cellular response to oncogenic ras involves induction of the Cdk4 and Cdk6 inhibitor p15(INK4b)

1 reference

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7 January 2021

JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression

1 reference

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7 January 2021

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

1 reference

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7 January 2021

Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle

1 reference

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7 January 2021

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15

1 reference

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7 January 2021

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Role of p14(ARF) in replicative and induced senescence of human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

INK4d-deficient mice are fertile despite testicular atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Effects of an Rb mutation in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

The murine gene p27Kip1 is haplo-insufficient for tumour suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d)

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Invasive melanoma in Cdk4-targeted mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

To cycle or not to cycle: a critical decision in cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Detection of p16, RB, CDK4, and p53 gene deletion and amplification by fluorescence in situ hybridization in 96 gliomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Alteration of cyclin D1 and CDK4 gene in carcinoma of uterine cervix

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Mutations associated with familial melanoma impair p16INK4 function.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

The INK4 family of cell cycle inhibitors in cancer

1 reference

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7 January 2021

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Cyclin D1 and human neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Cyclin D1 in parathyroid disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Specific protection against breast cancers by cyclin D1 ablation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

CDK inhibition and cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Preclinical and clinical development of cyclin-dependent kinase modulators

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Crystal structure of cyclin-dependent kinase 2

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Cyclin-dependent kinases: inhibition and substrate recognition.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Cell cycle and biochemical effects of PD 0183812. A potent inhibitor of the cyclin D-dependent kinases CDK4 and CDK6.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Apoptosis in anititumor strategies: Modulation of cell cycle or differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

Expression of cyclin-dependent kinase 6 (cdk6) and frequent loss of CD44 in nasal-nasopharyngeal NK/T-cell lymphomas: comparison with CD56-negative peripheral T-cell lymphomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2802%2900037-9

7 January 2021

10.1016/S0304-419X(02)00037-9

Identifiers

DOI

1 reference

3 August 2017

1 reference