Leptin receptor (Lepr) is a negative modulator of bone mechanosensitivity and genetic variations in Lepr may contribute to the differential osteogenic response to mechanical stimulation in the C57BL/6J and C3H/HeJ pair of mouse strains. (Q34333725)

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English	Leptin receptor (Lepr) is a negative modulator of bone mechanosensitivity and genetic variations in Lepr may contribute to the differential osteogenic response to mechanical stimulation in the C57BL/6J and C3H/HeJ pair of mouse strains.	scientific article

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14 February 2020

Leptin receptor (Lepr) is a negative modulator of bone mechanosensitivity and genetic variations in Lepr may contribute to the differential osteogenic response to mechanical stimulation in the C57BL/6J and C3H/HeJ pair of mouse strains (English)

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14 February 2020

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14 February 2020

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Sonia Kapur

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14 February 2020

Mehran Amoui

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14 February 2020

Chandrasekhar Kesavan

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14 February 2020

Xiaoguang Wang

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14 February 2020

Subburaman Mohan

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14 February 2020

David J Baylink

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17 September 2010

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14 February 2020

Journal of Biological Chemistry

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14 February 2020

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14 February 2020

37607-37618

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14 February 2020

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Loss of sex-specific difference in femoral bone parameters in male leptin knockout mice.

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

Leptin deficiency produces contrasting phenotypes in bones of the limb and spine

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6 July 2018

Activation of the Leptin Receptor by a Ligand-induced Conformational Change of Constitutive Receptor Dimers

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6 July 2018

A unified model for the action of leptin on bone turnover

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6 July 2018

Bone tissue engineering: the role of interstitial fluid flow

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6 July 2018

Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization

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6 July 2018

Expression of functional gap junctions and regulation by fluid flow in osteocyte-like MLO-Y4 cells

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Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

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6 July 2018

New method for genotyping the mouse Lep(ob) mutation, using a polymerase chain reaction assay.

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6 July 2018

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6 July 2018

Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding

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6 July 2018

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6 July 2018

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6 July 2018

The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

Exercise and mechanical loading increase periosteal bone formation and whole bone strength in C57BL/6J mice but not in C3H/Hej mice

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21 January 2018

Mechanical loading-induced gene expression and BMD changes are different in two inbred mouse strains.

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21 January 2018

Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross.

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21 January 2018

Novel loci regulating bone anabolic response to loading: expression QTL analysis in C57BL/6JXC3H/HeJ mice cross.

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21 January 2018

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21 January 2018

Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size

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21 January 2018

Fluid flow shear stress stimulates human osteoblast proliferation and differentiation through multiple interacting and competing signal transduction pathways.

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Leptin receptor genotype at Gln223Arg is associated with body composition, BMD, and vertebral fracture in postmenopausal Danish women

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21 January 2018

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21 January 2018

Bone response to in vivo mechanical loading in C3H/HeJ mice

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ablation of estrogen receptor alpha (ERalpha) prevents upregulation of POMC by leptin and insulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanotransduction in bone: genetic effects on mechanosensitivity in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for a skeletal mechanosensitivity gene on mouse chromosome 4

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo and in vitro evidence that the high osteoblastic activity in C3H/HeJ mice compared to C57BL/6J mice is intrinsic to bone cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early loading-related changes in the activity of glucose 6-phosphate dehydrogenase and alkaline phosphatase in osteocytes and periosteal osteoblasts in rat fibulae in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Function of osteocytes in bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone response to in vivo mechanical loading in two breeds of mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20851886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M110.169714

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14 February 2020

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14 February 2020

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14 February 2020

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