Apoptosis-regulating proteins as targets for drug discovery (Q34293102)

1 August 2017

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title

Apoptosis-regulating proteins as targets for drug discovery (English)

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1 August 2017

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Reed JC

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1 August 2017

publication date

1 July 2001

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Trends in Molecular Medicine

1 August 2017

published in

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

314-319

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1 August 2017

cites work

Apoptosis: an overview

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

1 reference

7 January 2021

Caspases: intracellular signaling by proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Caspase activation: the induced-proximity model

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Tumor necrosis factor receptor and Fas signaling mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Transducing signals of life and death

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Cytochrome c: can't live with it--can't live without it.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Differential requirement for caspase 9 in apoptotic pathways in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

The atomic-resolution structure of human caspase-8, a key activator of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Structure and mechanism of interleukin-1 beta converting enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Conformationally constrained inhibitors of caspase-1 (interleukin-1 beta converting enzyme) and of the human CED-3 homologue caspase-3 (CPP32, apopain)

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Defects in regulation of apoptosis in caspase-2-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Inhibition of caspase activity prevents CD95-mediated hepatic microvascular perfusion failure and restores Kupffer cell clearance capacity

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

The CARD domain: a new apoptotic signalling motif

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

The NACHT family - a new group of predicted NTPases implicated in apoptosis and MHC transcription activation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

ATP-activated oligomerization as a mechanism for apoptosis regulation: fold and mechanism prediction for CED-4.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

IAP family proteins--suppressors of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

An exegesis of IAPs: salvation and surprises from BIR motifs

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Insights into programmed cell death through structural biology

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

An emerging blueprint for apoptosis in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Mechanisms of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

The Bcl-2 protein family: arbiters of cell survival

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Mitochondrial control of cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Bcl-2 family proteins as ion-channels

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Bcl-2-family proteins: the role of the BH3 domain in apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Apoptosis control by death and decoy receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Promise and Problems of Bcl-2 Antisense Therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1471-4914%2801%2902026-3

7 January 2021

10.1016/S1471-4914(01)02026-3

Identifiers

DOI

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1 August 2017

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