Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses (Q34275810)

1 August 2017

title

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses (English)

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1 August 2017

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Carlos P Rubbi

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1 August 2017

Jo Milner

series ordinal

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1 August 2017

language of work or name

English

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publication date

1 November 2003

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1 August 2017

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1 August 2017

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1 August 2017

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1 August 2017

page(s)

6068-6077

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Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway

1 August 2017

cites work

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p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage

6 July 2018

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6 July 2018

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6 July 2018

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Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage

6 July 2018

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6 July 2018

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Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

6 July 2018

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6 July 2018

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Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

6 July 2018

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Common and reversible regulation of wild-type p53 function and of ribosomal biogenesis by protein kinases in human cells

6 July 2018

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Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

6 July 2018

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

6 July 2018

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6 July 2018

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Repression of RNA polymerase I transcription by the tumor suppressor p53

6 July 2018

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6 July 2018

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Mechanisms of switching on p53: a role for covalent modification?

6 July 2018

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Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells

6 July 2018

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

6 July 2018

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Cell cycle-dependent regulation of RNA polymerase I transcription: the nucleolar transcription factor UBF is inactive in mitosis and early G1.

6 July 2018

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DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

6 July 2018

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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

6 July 2018

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p53 represses ribosomal gene transcription

6 July 2018

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

6 July 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

6 July 2018

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Cisplatin inhibits synthesis of ribosomal RNA in vivo

6 July 2018

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p53 is a general repressor of RNA polymerase III transcription

6 July 2018

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Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5

6 July 2018

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Transcription abnormalities potentiate apoptosis of normal human fibroblasts.

6 July 2018

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Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

6 July 2018

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Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

6 July 2018

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6 July 2018

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Cytoplasmic p53 polypeptide is associated with ribosomes

6 July 2018

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Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

6 July 2018

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Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation

6 July 2018

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p53, the cellular gatekeeper for growth and division

6 July 2018

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An information-intensive approach to the molecular pharmacology of cancer.

6 July 2018

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Heat shock disassembles the nucleolus and inhibits nuclear protein import and poly(A)+ RNA export

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Quantitation of the nucleophosmin/B23-translocation using imaging analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Protein p53 modulates transcription from a promoter containing its binding site in a concentration-dependent manner.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Lack of transcription-coupled repair in mammalian ribosomal RNA genes

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Nucleolar protein B23 translocation after deferoxamine treatment in a human leukemia cell line

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

The tumor suppressor p53 is bound to RNA by a stable covalent linkage

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

p53 is covalently linked to 5.8S rRNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Proof without prejudice: use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sources

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Ultrastructural and autoradiographic study of the effects of bleomycin on the interphase nucleus of cultured normal cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Local UV-induced DNA damage in cell nuclei results in local transcription inhibition

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Accumulation of soluble and nucleolar-associated p53 proteins following cellular stress.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

Impaired DNA repair capacity in skin fibroblasts from various hereditary cancer-prone syndromes.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

RNA synthesis inhibitors alter the subnuclear distribution of DNA topoisomerase I

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275437

U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle

28 October 2018

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12 December 2020

Inhibition of RNA polymerase II transcription causes chromatin decondensation, loss of nucleolar structure, and dispersion of chromosomal domains

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12 December 2020

Murine tumor suppressor models

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12 December 2020

Inhibition of RNA polymerase II as a trigger for the p53 response

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12 December 2020

p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products

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12 December 2020

Control of nucleolar RNA synthesis by the intracellular pool sizes of ATP and GTP

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12 December 2020

Ultrastructural changes in nucleoli and fibrillar centers under the effect of local ultraviolet microbeam irradiation of interphase culture cells

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12 December 2020

Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosis

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12 December 2020

Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/CDG579

1 reference

1 August 2017

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1 August 2017

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