Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line. (Q34264069)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22454432%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

title

Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line (English)

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27 January 2020

0 references

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27 January 2020

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27 January 2020

Stephen J Fey

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PubMed publication ID

22454432

1 August 2017

Krzysztof Wrzesinski

series ordinal

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PubMed publication ID

22454432

1 August 2017

publication date

27 March 2012

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27 January 2020

published in

Toxicological Sciences

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27 January 2020

volume

127

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27 January 2020

issue

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27 January 2020

page(s)

403-411

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Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

27 January 2020

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Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use.

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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28 October 2018

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28 October 2018

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28 October 2018

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28 October 2018

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28 October 2018

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28 October 2018

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28 October 2018

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28 October 2018

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28 October 2018

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Use of population modeling to define rational monitoring of amiodarone hepatic effects

28 October 2018

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28 October 2018

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28 October 2018

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Characterisation of some cytotoxic endpoints using rat liver and HepG2 spheroids as in vitro models and their application in hepatotoxicity studies. I. Glucose metabolism and enzyme release as cytotoxic markers.

28 October 2018

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4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine

28 October 2018

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28 October 2018

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28 October 2018

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28 October 2018

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28 October 2018

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Modulation of cytochrome P450 gene expression in primary hepatocytes on various artificial extracellular matrices

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12 December 2020

Diclofenac and Its Derivatives As Tools for Studying Human Cytochromes P450 Active Sites: Particular Efficiency and Regioselectivity of P450 2Cs

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Acetaminophen-induced hepatotoxicity in a liver tissue model consisting of primary hepatocytes assembling around an endothelial cell network

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Molecular mechanism of diclofenac hepatotoxicity: Association of cell injury with oxidative metabolism and decrease in ATP levels

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Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity

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CYP4 isozyme specificity and the relationship between omega-hydroxylation and terminal desaturation of valproic acid

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Low-shear modelled microgravity environment maintains morphology and differentiated functionality of primary porcine hepatocyte cultures

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The toxicity of metabolites of sodium valproate in cultured hepatocytes

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Glutathione depletion by valproic acid in sandwich-cultured rat hepatocytes: Role of biotransformation and temporal relationship with onset of toxicity

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The blooming of the French lilac

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12 April 2024

https://opencitations.net/index/api/v1/citations/10.1172/JCI14178

Identifiers

DOI

10.1093/TOXSCI/KFS122

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22454432%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22454432%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

PubMed publication ID

22454432

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22454432%20AND%20SRC:MED&resulttype=core&format=json