Parc: a cytoplasmic anchor for p53. (Q34170344)

31 July 2017

title

Parc: a cytoplasmic anchor for p53. (English)

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31 July 2017

Anatoly Y Nikolaev

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31 July 2017

Muyang Li

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31 July 2017

Norbert Puskas

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31 July 2017

Jun Qin

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31 July 2017

Wei Gu

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31 July 2017

language of work or name

English

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publication date

1 January 2003

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31 July 2017

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31 July 2017

volume

112

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31 July 2017

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31 July 2017

page(s)

29-40

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The ribosomal 5.8S RNA as a target site for p53 protein in cell differentiation and oncogenesis

31 July 2017

cites work

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Definition of a consensus binding site for p53

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Cytoplasmic p53 polypeptide is associated with ribosomes

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Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

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Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport

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The MDM2 RING-finger domain is required to promote p53 nuclear export

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p53 is associated with cellular microtubules and is transported to the nucleus by dynein

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Identification of p53 sequence elements that are required for MDM2-mediated nuclear export

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A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation

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The function of PML in p53-dependent apoptosis

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New approaches to understanding p53 gene tumor mutation spectra

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

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p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Cytoplasmic retention of mutant tsp53 is dependent on an intermediate filament protein (vimentin) scaffold

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Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

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Acetylation of p53 inhibits its ubiquitination by Mdm2.

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Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein

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C-terminal ubiquitination of p53 contributes to nuclear export

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Deacetylation of p53 modulates its effect on cell growth and apoptosis

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7 January 2021

Negative control of p53 by Sir2alpha promotes cell survival under stress

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7 January 2021

Wild-type p53 protein shows calcium-dependent binding to F-actin

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7 January 2021

The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited

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Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

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7 January 2021

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

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Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

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Mechanisms underlying ubiquitination

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Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells

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Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells

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p53: good cop/bad cop.

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7 January 2021

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

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7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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7 January 2021

Prognostic significance of cytoplasmic p53 oncoprotein in colorectal adenocarcinoma

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7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

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Functional inactivation but not structural mutation of p53 causes liver cancer.

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Surfing the p53 network

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Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

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7 January 2021

Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation

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7 January 2021

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

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7 January 2021

10.1016/S0092-8674(02)01255-2

Identifiers

DOI

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31 July 2017

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