Cellular strategies for controlling protein aggregation (Q34143451)

31 July 2017

title

Cellular strategies for controlling protein aggregation (English)

1 reference

31 July 2017

1 reference

Bernd Bukau

1 reference

31 July 2017

Axel Mogk

1 reference

31 July 2017

Jens Tyedmers

1 reference

31 July 2017

publication date

14 October 2010

1 reference

Nature Reviews Molecular Cell Biology

31 July 2017

published in

1 reference

31 July 2017

1 reference

31 July 2017

1 reference

31 July 2017

page(s)

777-788

1 reference

Crystallins and hereditary cataracts: molecular mechanisms and potential for therapy

31 July 2017

cites work

1 reference

Multidimensional structure-activity relationship of a protein in its aggregated states

21 January 2018

1 reference

ClpB is the Escherichia coli heat shock protein F84.1.

21 January 2018

1 reference

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

21 January 2018

1 reference

Intracellular localization of proteasomal degradation of a viral antigen

21 January 2018

1 reference

ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy

21 January 2018

1 reference

Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway.

21 January 2018

1 reference

p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases

21 January 2018

1 reference

Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomes

21 January 2018

1 reference

Protein folding and misfolding

21 January 2018

1 reference

The Yin and Yang of protein folding

31 March 2020

1 reference

Progressive disruption of cellular protein folding in models of polyglutamine diseases.

31 March 2020

1 reference

Specificity in intracellular protein aggregation and inclusion body formation

31 March 2020

1 reference

Proteinaceous infectious behavior in non-pathogenic proteins is controlled by molecular chaperones.

31 March 2020

1 reference

Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis.

31 March 2020

1 reference

Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

31 March 2020

1 reference

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

31 March 2020

1 reference

Protein degradation and protection against misfolded or damaged proteins

31 March 2020

1 reference

Converging concepts of protein folding in vitro and in vivo

31 March 2020

1 reference

Quality control in the endoplasmic reticulum

31 March 2020

1 reference

ERAD: the long road to destruction

31 March 2020

1 reference

The roles of intracellular protein-degradation pathways in neurodegeneration

31 March 2020

1 reference

Molecular chaperones and protein quality control

31 March 2020

1 reference

Two families of chaperonin: physiology and mechanism

31 March 2020

1 reference

Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets.

31 March 2020

1 reference

A role for ubiquitin in selective autophagy

31 March 2020

1 reference

Dynamics and diversity in autophagy mechanisms: lessons from yeast

31 March 2020

1 reference

Regulation mechanisms and signaling pathways of autophagy

31 March 2020

1 reference

Biological and chemical approaches to diseases of proteostasis deficiency

31 March 2020

1 reference

Convergence of Molecular, Modeling, and Systems Approaches for an Understanding of the Escherichia coli Heat Shock Response

31 March 2020

1 reference

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

31 March 2020

1 reference

Signal integration in the endoplasmic reticulum unfolded protein response

31 March 2020

1 reference

Protein misfolding, functional amyloid, and human disease

31 March 2020

1 reference

Protein aggregation and neurodegenerative disease

31 March 2020

1 reference

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

31 March 2020

1 reference

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6

31 March 2020

1 reference

Parkin-mediated ubiquitin signalling in aggresome formation and autophagy

31 March 2020

1 reference

Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution.

31 March 2020

1 reference

Dendritic cells, DRiPs, and DALIS in the control of antigen processing.

31 March 2020

1 reference

Protein disaggregation mediated by heat-shock protein Hsp104.

31 March 2020

1 reference

31 March 2020

1 reference

Role of oxidative carbonylation in protein quality control and senescence

31 March 2020

1 reference

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

31 March 2020

1 reference

Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.

31 March 2020

1 reference

Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants

31 March 2020

1 reference

Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p

31 March 2020

1 reference

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

31 March 2020

1 reference

Amyloids in bacterial inclusion bodies

31 March 2020

1 reference

On the structural definition of amyloid fibrils and other polypeptide aggregates

31 March 2020

1 reference

Structure-activity relationship of amyloid fibrils.

31 March 2020

1 reference

Recent atomic models of amyloid fibril structure

31 March 2020

1 reference

Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis show enhanced formation of aggregates in vitro

31 March 2020

1 reference

Structural insights into a yeast prion illuminate nucleation and strain diversity

31 March 2020

1 reference

The structural basis of yeast prion strain variants

31 March 2020

1 reference

Molecular mechanisms for protein-encoded inheritance

31 March 2020

1 reference

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

31 March 2020

1 reference

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

31 March 2020

1 reference

Chaperone-dependent amyloid assembly protects cells from prion toxicity

31 March 2020

1 reference

Opposing activities protect against age-onset proteotoxicity

31 March 2020

1 reference

Anchorless prion protein results in infectious amyloid disease without clinical scrapie

31 March 2020

1 reference

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

31 March 2020

1 reference

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

31 March 2020

1 reference

Dynamic association of proteasomal machinery with the centrosome

31 March 2020

1 reference

Misfolded proteins partition between two distinct quality control compartments

31 March 2020

1 reference

Protein aggregation and inclusion body formation in Escherichia coli rpoH mutant defective in heat shock protein induction.

31 March 2020

1 reference

Aggregation of heat-shock-denatured, endogenous proteins and distribution of the IbpA/B and Fda marker-proteins in Escherichia coli WT and grpE280 cells

31 March 2020

1 reference

Protein quality in bacterial inclusion bodies.

31 March 2020

1 reference

Aggresomes, inclusion bodies and protein aggregation

31 March 2020

1 reference

Localization of general and regulatory proteolysis in Bacillus subtilis cells.

31 March 2020

1 reference

Asymmetric segregation of protein aggregates is associated with cellular aging and rejuvenation.

31 March 2020

1 reference

Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing

31 March 2020

1 reference

Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB.

31 March 2020

1 reference

E. coli transports aggregated proteins to the poles by a specific and energy-dependent process

31 March 2020

1 reference

Use of yeast as a model system to investigate protein conformational diseases

31 March 2020

1 reference

The [URE3] prion is an aggregated form of Ure2p that can be cured by overexpression of Ure2p fragments

31 March 2020

1 reference

Support for the prion hypothesis for inheritance of a phenotypic trait in yeast

31 March 2020

1 reference

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

31 March 2020

1 reference

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins

31 March 2020

1 reference

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

31 March 2020

1 reference

Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation

31 March 2020

1 reference

Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

31 March 2020

1 reference

Aggresomes: a cellular response to misfolded proteins

31 March 2020

1 reference

Hassles with taking out the garbage: aggravating aggresomes.

31 March 2020

1 reference

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

31 March 2020

1 reference

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

31 March 2020

1 reference

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

31 March 2020

1 reference

Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

31 March 2020

1 reference

Hsp70 chaperones accelerate protein translocation and the unfolding of stable protein aggregates by entropic pulling

31 March 2020

1 reference

Heat shock protein 101 plays a crucial role in thermotolerance in Arabidopsis.

31 March 2020

1 reference

HSP104 required for induced thermotolerance

31 March 2020

1 reference

Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

31 March 2020

1 reference

Successive and synergistic action of the Hsp70 and Hsp100 chaperones in protein disaggregation

31 March 2020

1 reference

M domains couple the ClpB threading motor with the DnaK chaperone activity

31 March 2020

1 reference

Protein disaggregation by the AAA+ chaperone ClpB involves partial threading of looped polypeptide segments.

31 March 2020

1 reference

Evidence for an unfolding/threading mechanism for protein disaggregation by Saccharomyces cerevisiae Hsp104.

31 March 2020

1 reference

Substrate recognition by the AAA+ chaperone ClpB.

31 March 2020

1 reference

Activation of the chaperone Hsp26 is controlled by the rearrangement of its thermosensor domain

31 March 2020

1 reference

Some like it hot: the structure and function of small heat-shock proteins.

31 March 2020

1 reference

Hsp26: a temperature-regulated chaperone

31 March 2020

1 reference

Quaternary dynamics and plasticity underlie small heat shock protein chaperone function

31 March 2020

1 reference

Refolding of substrates bound to small Hsps relies on a disaggregation reaction mediated most efficiently by ClpB/DnaK.

31 March 2020

1 reference

HSP16.6 is involved in the development of thermotolerance and thylakoid stability in the unicellular cyanobacterium, Synechocystis sp. PCC 6803

31 March 2020

1 reference

Small heat shock proteins, ClpB and the DnaK system form a functional triade in reversing protein aggregation

31 March 2020

1 reference

Distinct activities of Escherichia coli small heat shock proteins IbpA and IbpB promote efficient protein disaggregation.

31 March 2020

1 reference

Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation.

31 March 2020

1 reference

A small heat shock protein stably binds heat-denatured model substrates and can maintain a substrate in a folding-competent state

31 March 2020

1 reference

ClpS, a substrate modulator of the ClpAP machine

31 March 2020

1 reference

MecA, an adaptor protein necessary for ClpC chaperone activity

31 March 2020

1 reference

Saccharomyces cerevisiae Hsp104 enhances the chaperone capacity of human cells and inhibits heat stress-induced proapoptotic signaling

31 March 2020

1 reference

Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans

31 March 2020

1 reference

Transient aggregation of ubiquitinated proteins during dendritic cell maturation

31 March 2020

1 reference

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

31 March 2020

1 reference

Insights into adaptor binding to the AAA protein p97.

31 March 2020

1 reference

Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

31 March 2020

1 reference

RNA interference of valosin-containing protein (VCP/p97) reveals multiple cellular roles linked to ubiquitin/proteasome-dependent proteolysis

31 March 2020

1 reference

Involvement of valosin-containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates.

31 March 2020

1 reference

HDAC6-p97/VCP controlled polyubiquitin chain turnover

31 March 2020

1 reference

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

31 March 2020

1 reference

Protein quality control: chaperones culling corrupt conformations

31 March 2020

1 reference

Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.

31 March 2020

1 reference

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

31 March 2020

1 reference

Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins

31 March 2020

1 reference

Degradation-mediated protein quality control in the nucleus

31 March 2020

1 reference

Activity and regulation of the centrosome-associated proteasome

31 March 2020

1 reference

Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease.

31 March 2020

1 reference

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

31 March 2020

1 reference

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

31 March 2020

1 reference

Impairment of the ubiquitin-proteasome system by protein aggregation

31 March 2020

1 reference

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

31 March 2020

1 reference

Inefficient degradation of truncated polyglutamine proteins by the proteasome

31 March 2020

1 reference

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

31 March 2020

1 reference

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

31 March 2020

1 reference

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

31 March 2020

1 reference

Emerging role for autophagy in the removal of aggresomes in Schwann cells.

31 March 2020

1 reference

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

31 March 2020

1 reference

Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

31 March 2020

1 reference

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

31 March 2020

1 reference

Loss of autophagy in the central nervous system causes neurodegeneration in mice

31 March 2020

1 reference

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

31 March 2020

1 reference

Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins

31 March 2020

1 reference

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

31 March 2020

1 reference

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

31 March 2020

1 reference

Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies

31 March 2020

1 reference

Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation.

31 March 2020

1 reference

Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions.

31 March 2020

1 reference

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

31 March 2020

1 reference

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

31 March 2020

1 reference

The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy

31 March 2020

1 reference

Autophagy fights disease through cellular self-digestion

31 March 2020

1 reference

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

31 March 2020

1 reference

Polyglutamine protein aggregates are dynamic

31 March 2020

1 reference

Protein aggregates: an aging factor involved in cell death

31 March 2020

1 reference

A mother's sacrifice: what is she keeping for herself?

31 March 2020

1 reference

Replicative aging in yeast: the means to the end

31 March 2020

1 reference

Asymmetric inheritance of oxidatively damaged proteins during cytokinesis

31 March 2020

1 reference

The polarisome is required for segregation and retrograde transport of protein aggregates.

31 March 2020

1 reference

The yeast AAA+ chaperone Hsp104 is part of a network that links the actin cytoskeleton with the inheritance of damaged proteins

31 March 2020

1 reference

Asymmetric mitosis: Unequal segregation of proteins destined for degradation

31 March 2020

1 reference

Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes

31 March 2020

1 reference

Asymmetric divisions, aggresomes and apoptosis

31 March 2020

1 reference

Centrosome duplication. a centriolar pas de deux

31 March 2020

1 reference

Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells.

31 March 2020

1 reference

A role for a novel centrosome cycle in asymmetric cell division

31 March 2020

1 reference

Asymmetric inheritance of mother versus daughter centrosome in stem cell division

31 March 2020

1 reference

Protein self-organization in vitro and in vivo: partitioning between physical biochemistry and cell biology

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20944667

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two novel heat shock genes encoding proteins produced in response to heterologous protein expression in Escherichia coli

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20944667

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM2993

1 reference

Dimensions Publication ID

31 July 2017

1009498497

0 references

1 reference