Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators (Q34134678)

31 July 2017

title

Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators (English)

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31 July 2017

Craig W Lindsley

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31 July 2017

P Jeffrey Conn

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31 July 2017

Corey R Hopkins

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31 July 2017

Thomas M Bridges

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31 July 2017

J Phillip Kennedy

series ordinal

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31 July 2017

language of work or name

English

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publication date

12 August 2010

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Bioorganic & Medicinal Chemistry Letters

31 July 2017

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inferred from page(s)

published in

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

5617-5622

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Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system

31 July 2017

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Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

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Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM

5 July 2018

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Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.

5 July 2018

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Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators

5 July 2018

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Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease.

5 July 2018

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Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor

5 July 2018

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Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)

5 July 2018

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Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

5 July 2018

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Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

5 July 2018

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Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity

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Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

5 July 2018

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Synthesis and SAR of analogs of the M1 allosteric agonist TBPB. Part II: Amides, sulfonamides and ureas--the effect of capping the distal basic piperidine nitrogen

5 July 2018

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Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties

5 July 2018

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Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

5 July 2018

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Application of combinatorial chemistry science on modern drug discovery

5 July 2018

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10.1016/J.BMCL.2010.08.042

5 July 2018

Identifiers

DOI

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31 July 2017

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31 July 2017

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