Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes (Q34126244)

31 July 2017

title

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes (English)

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31 July 2017

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Carl de Luca

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31 July 2017

Timothy J Kowalski

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31 July 2017

Yiying Zhang

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31 July 2017

Joel K Elmquist

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31 July 2017

Charlotte Lee

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31 July 2017

Manfred W Kilimann

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31 July 2017

Thomas Ludwig

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31 July 2017

Shun-Mei Liu

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31 July 2017

Streamson C Chua

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31 July 2017

language of work or name

English

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publication date

10 November 2005

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Journal of Clinical Investigation

31 July 2017

published in

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31 July 2017

volume

115

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31 July 2017

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31 July 2017

page(s)

3484-3493

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Hypothalamic cocaine- and amphetamine-regulated transcript neurons project to areas expressing gonadotropin releasing hormone immunoreactivity and to the anteroventral periventricular nucleus in male and female rats.

31 July 2017

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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Transgenic complementation of leptin receptor deficiency. II. Increased leptin receptor transgene dose effects on obesity/diabetes and fertility/lactation in lepr-db/db mice

5 July 2018

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Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites.

5 July 2018

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STAT3 signalling is required for leptin regulation of energy balance but not reproduction

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent

5 July 2018

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5 July 2018

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Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases

5 July 2018

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Distributions of leptin receptor mRNA isoforms in the rat brain

5 July 2018

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5 July 2018

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Regulation of Cre recombinase activity by mutated estrogen receptor ligand-binding domains

5 July 2018

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5 July 2018

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Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism

5 July 2018

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Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

5 July 2018

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Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

5 July 2018

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Positional cloning of the mouse obese gene and its human homologue

5 July 2018

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Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

5 July 2018

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Ventral premammillary nuclei mediate pheromonal-induced LH release stimuli in the rat.

5 July 2018

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Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db).

5 July 2018

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An allelic series for the leptin receptor gene generated by CRE and FLP recombinase

5 July 2018

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Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

28 October 2018

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Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance

28 October 2018

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Validation of a quantitative method for real time PCR kinetics

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280964

Transgenic complementation of leptin-receptor deficiency. I. Rescue of the obesity/diabetes phenotype of LEPR-null mice expressing a LEPR-B transgene

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1280964

The central melanocortin system can directly regulate serum insulin levels

28 October 2018

1 reference

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Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

28 October 2018

1 reference

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Upstream and intron regulatory regions for expression of the rat neuron-specific enolase gene

28 October 2018

1 reference

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The 5'-flanking region of the rat synapsin I gene directs neuron-specific and developmentally regulated reporter gene expression in transgenic mice

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16284652

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Induction of Galphaq-specific antisense RNA in vivo causes increased body mass and hyperadiposity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16284652

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Female-soiled bedding induced fos immunoreactivity in the ventral part of the premammillary nucleus (PMv) of the male mouse

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16284652

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI24059

1 reference

31 July 2017

1 reference

31 July 2017

1 reference