Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. (Q34069706)

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8 February 2020

title

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease (English)

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8 February 2020

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8 February 2020

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8 February 2020

Ramnik J Xavier

1 reference

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8 February 2020

Bin Zheng

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8 February 2020

Tao Lu

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8 February 2020

Zhenyu Yan

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8 February 2020

Aylwin Ng

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8 February 2020

Cheng Li

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8 February 2020

Bruce A Yankner

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8 February 2020

Clemens R Scherzer

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8 February 2020

Junying Yuan

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8 February 2020

language of work or name

English

0 references

publication date

26 July 2010

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

8 February 2020

published in

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8 February 2020

volume

107

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8 February 2020

issue

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8 February 2020

page(s)

14164-14169

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A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions

8 February 2020

cites work

1 reference

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Control of basal autophagy by calpain1 mediated cleavage of ATG5

5 July 2018

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Autophagy promotes synapse development in Drosophila

5 July 2018

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Autophagy protects neuron from Abeta-induced cytotoxicity

5 July 2018

1 reference

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Evolution of the aging brain transcriptome and synaptic regulation

5 July 2018

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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

5 July 2018

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FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

5 July 2018

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Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

5 July 2018

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Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

5 July 2018

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Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

5 July 2018

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Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons

5 July 2018

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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

5 July 2018

1 reference

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CellProfiler: image analysis software for identifying and quantifying cell phenotypes

5 July 2018

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

5 July 2018

1 reference

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

5 July 2018

1 reference

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Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

5 July 2018

1 reference

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

5 July 2018

1 reference

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Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922576

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

5 July 2018

1 reference

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Development by self-digestion: molecular mechanisms and biological functions of autophagy

5 July 2018

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Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

5 July 2018

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A comprehensive two-hybrid analysis to explore the yeast protein interactome

5 July 2018

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Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection

5 July 2018

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Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

5 July 2018

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Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

5 July 2018

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ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction

28 October 2018

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ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

28 October 2018

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Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20660724

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1009485107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660724%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

0 references

1 reference

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8 February 2020

PubMed publication ID

20660724

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20660724%20AND%20SRC:MED&resulttype=core&format=json