Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease (Q34058185)

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18 March 2020

title

Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease (English)

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18 March 2020

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18 March 2020

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18 March 2020

Maria T Bahia

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18 March 2020

Alvaro F S Nascimento

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18 March 2020

Ana Lia Mazzeti

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18 March 2020

Luiz F Marques

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18 March 2020

Karolina R Gonçalves

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18 March 2020

Ludmilla W R Mota

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18 March 2020

Lívia de F Diniz

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18 March 2020

Ivo S Caldas

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18 March 2020

David M Shackleford

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18 March 2020

Maria Koltun

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18 March 2020

Jessica Saunders

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18 March 2020

Karen L White

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18 March 2020

Ivan Scandale

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18 March 2020

Eric Chatelain

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18 March 2020

language of work or name

English

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publication date

19 May 2014

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Antimicrobial Agents and Chemotherapy

18 March 2020

published in

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18 March 2020

volume

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18 March 2020

issue

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18 March 2020

page(s)

4362-4370

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Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studies

18 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Fexinidazole: a potential new drug candidate for Chagas disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Rapid quantitation of Trypanosoma cruzi in host tissue by real-time PCR.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

The activity of fexinidazole (HOE 239) against experimental infections with Trypanosoma cruzi, trichomonads and Entamoeba histolytica

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Enzyme immunoassays in diagnostic medicine. Theory and practice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Real-time PCR strategy for parasite quantification in blood and tissue samples of experimental Trypanosoma cruzi infection.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Benznidazole therapy during acute phase of Chagas disease reduces parasite load but does not prevent chronic cardiac lesions.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

Trypanosoma cruzi: acute and long-term infection in the vertebrate host can modify the response to benznidazole

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4136024

28 October 2018

Identifiers

DOI

10.1128/AAC.02754-13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24841257%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

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18 March 2020

PubMed publication ID

24841257

1 reference

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