Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras (Q33993387)

30 July 2017

title

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras (English)

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30 July 2017

1 reference

Neal G Copeland

1 reference

30 July 2017

Nancy A Jenkins

1 reference

30 July 2017

Jeannette M Bonifas

1 reference

30 July 2017

Jennifer O Lauchle

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30 July 2017

Doris Kim

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30 July 2017

Doan T Le

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30 July 2017

Keiko Akagi

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30 July 2017

Michael Crone

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30 July 2017

Kimberly Krisman

1 reference

30 July 2017

Kegan Warner

1 reference

30 July 2017

Qing Li

1 reference

30 July 2017

Kristen M Coakley

1 reference

30 July 2017

Ernesto Diaz-Flores

1 reference

30 July 2017

Matthew Gorman

1 reference

30 July 2017

Sally Przybranowski

1 reference

30 July 2017

Mary Tran

1 reference

30 July 2017

Scott C Kogan

1 reference

30 July 2017

Jeroen P Roose

1 reference

30 July 2017

Luis Parada

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30 July 2017

Linda Wolff

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30 July 2017

Judith Sebolt-Leopold

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30 July 2017

Kevin Shannon

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30 July 2017

language of work or name

English

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publication date

2 September 2009

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30 July 2017

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30 July 2017

volume

461

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30 July 2017

issue

7262

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30 July 2017

page(s)

411-414

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Digital signaling and hysteresis characterize ras activation in lymphoid cells

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

The selectivity of protein kinase inhibitors: a further update

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Hyperactive Ras in developmental disorders and cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Inherited predispositions and hyperactive Ras in myeloid leukemogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

A small molecule-kinase interaction map for clinical kinase inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Focus on myeloproliferative diseases and myelodysplastic syndromes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Role of the p38 mitogen-activated protein kinase pathway in the generation of the effects of imatinib mesylate (STI571) in BCR-ABL-expressing cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

RTCGD: retroviral tagged cancer gene database

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

A Moloney murine leukemia virus-based retrovirus with 4070A long terminal repeat sequences induces a high incidence of myeloid as well as lymphoid neoplasms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Targeting RAS signalling pathways in cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Regulation of Ras in lymphocytes: get a GRP.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4119783

Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19727076

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19727076

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pharmacodynamic and toxicokinetic evaluation of the novel MEK inhibitor, PD0325901, in the rat following oral and intravenous administration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19727076

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE08279

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Dimensions Publication ID

30 July 2017

0 references

1 reference

30 July 2017

1 reference