Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis (Q33779169)

29 July 2017

title

Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis (English)

1 reference

29 July 2017

1 reference

Wei Li

1 reference

29 July 2017

Feng Gao

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29 July 2017

Xiaoqian Ma

1 reference

29 July 2017

Ruike Wang

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29 July 2017

Xin Dong

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29 July 2017

Wei Wang

1 reference

29 July 2017

language of work or name

English

0 references

publication date

6 March 2017

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29 July 2017

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

32586-32599

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From Krebs to clinic: glutamine metabolism to cancer therapy.

29 July 2017

cites work

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4 July 2018

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Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer

4 July 2018

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4 July 2018

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A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis

4 July 2018

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4 July 2018

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Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis

4 July 2018

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4 July 2018

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Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy

4 July 2018

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4 July 2018

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Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

4 July 2018

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4 July 2018

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Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464811

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

4 July 2018

1 reference

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

4 July 2018

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Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells

4 July 2018

1 reference

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Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function

4 July 2018

1 reference

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Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464811

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis.

4 July 2018

1 reference

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ProvenCare lung cancer: a multi-institutional improvement collaborative

4 July 2018

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Lung cancer: New biological insights and recent therapeutic advances

30 October 2018

1 reference

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Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464811

Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464811

From Krebs to clinic: glutamine metabolism to cancer therapy

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28427230

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.15937

1 reference

29 July 2017

1 reference

29 July 2017

1 reference