The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma. (Q33756262)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15644444%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

title

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma (English)

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7 January 2020

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7 January 2020

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7 January 2020

Andrew Slack

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7 January 2020

Zaowen Chen

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7 January 2020

Roberto Tonelli

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7 January 2020

Lisa Hunt

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7 January 2020

Jason M Shohet

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7 January 2020

language of work or name

English

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publication date

11 January 2005

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7 January 2020

number of pages

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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7 January 2020

volume

102

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7 January 2020

issue

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7 January 2020

page(s)

731-736

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Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.

7 January 2020

cites work

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The peptide nucleic acids (PNAs), powerful tools for molecular genetics and cytogenetics

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21 June 2018

MYCN in neuronal tumours

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MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

21 June 2018

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21 June 2018

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Targeted inhibition of NMYC by peptide nucleic acid in N-myc amplified human neuroblastoma cells: cell-cycle inhibition with induction of neuronal cell differentiation and apoptosis.

21 June 2018

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p53-independent functions of MDM2.

21 June 2018

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Posttranslational modification of MDM2

21 June 2018

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Cell cycle regulatory functions of the human oncoprotein MDM2.

21 June 2018

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The MDM2-p53 interaction.

21 June 2018

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 June 2018

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Pediatric neuroblastomas: genetic and epigenetic 'danse macabre'.

21 June 2018

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Myc pathways provoking cell suicide and cancer

21 June 2018

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The requirement for evasion of programmed cell death in neuroblastomas with MYCN amplification

21 June 2018

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Genomic targets of the human c-Myc protein

21 June 2018

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Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

21 June 2018

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Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation

21 June 2018

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Identification of unknown target genes of human transcription factors using chromatin immunoprecipitation

21 June 2018

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ARF differentially modulates apoptosis induced by E2F1 and Myc.

21 June 2018

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Retinoblastoma protein transcriptional repression through histone deacetylation of a single nucleosome

21 June 2018

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Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis

21 June 2018

1 reference

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Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

21 June 2018

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Bax accelerates tumorigenesis in p53-deficient mice

21 June 2018

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Direct recruitment of N-myc to target gene promoters

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

The Myc/Max/Mad network and the transcriptional control of cell behavior

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

MDM2--master regulator of the p53 tumor suppressor protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group

21 June 2018

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MYC oncogenes and human neoplastic disease

21 June 2018

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New Myc-interacting proteins: a second Myc network emerges

21 June 2018

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Transient excess of MYC activity can elicit genomic instability and tumorigenesis

21 June 2018

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Targeted expression of MYCN causes neuroblastoma in transgenic mice

21 June 2018

1 reference

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Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells.

21 June 2018

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A functional p53-responsive intronic promoter is contained within the humanmdm2gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

Nucleotide sequence of the human N-myc gene

21 June 2018

1 reference

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Augmented MYCN expression advances the malignant phenotype of human neuroblastoma cells: evidence for induction of autocrine growth factor activity

21 June 2018

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Expression and function of myc family genes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

Enhanced MYCN oncogene expression in human neuroblastoma cells is associated with altered FGF receptor expression and cellular growth response to basic FGF.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

p21Cip1 gene expression is modulated by Egr1: a novel regulatory mechanism involved in the resveratrol antiproliferative effect.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

Role of two upstream open reading frames in the translational control of oncogene mdm2.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

Down-regulation of endothelial cell growth inhibitors by enhanced MYCN oncogene expression in human neuroblastoma cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=545522

Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis

30 October 2018

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12 December 2020

Gene targeting using peptide nucleic acid

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12 December 2020

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1 reference

12 December 2020

Absence of p53 gene mutations in primary neuroblastomas

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12 December 2020

Low frequency of the p53 gene mutations in neuroblastoma

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0405495102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15644444%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

0 references

1 reference

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7 January 2020

PubMed publication ID

15644444

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15644444%20AND%20SRC:MED&resulttype=core&format=json